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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Leu-enkephalin
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Accession:CHEBI:89656 term browser browse the term
Definition:A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.
Synonyms:exact_synonym: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
 related_synonym: (2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanoic acid;   Formula=C28H37N5O7;   H-Tyr-Gly-Gly-Phe-Leu-OH;   InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1;   InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N;   L-ENK;   L-Tyr-Gly-Gly-L-Phe-L-Leu;   Leu-ENK;   LeuENK;   Leucine enkephalin;   N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine;   SMILES=CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O;   Tyr-Gly-Gly-Phe-Leu;   Tyr-Gly-Gly-Phe-Leu-OH;   Y-G-G-F-L;   YGGFL;   [5-Leucine]Enkephalin;   [Leu 5]enkephalin;   enkephalin L;   leucyl-enkephalin
 alt_id: CHEBI:80263
 xref: CAS:58822-25-6;   Chemspider:406229;   FooDB:FDB022389;   HMDB:HMDB0001045;   KEGG:C16041
 xref_mesh: MESH:D004743
 xref: PMID:16802191;   PMID:20161518;   PMID:20669325;   PMID:22323423;   PMID:23661424;   PMID:23912034;   PMID:24480726;   PMID:2583565;   PMID:26723675;   PMID:26763532;   PMID:28233882;   PMID:28382489;   PMID:29351722;   PMID:29648788;   PMID:29793486;   PMID:29981318;   PMID:30014064;   PMID:30234204;   PMID:31843219;   PMID:32556047;   PMID:32961052;   PMID:33389463;   PMID:33573373;   PMID:33663067;   PMID:4069309;   PMID:9450624;   Reaxys:3582445;   Wikipedia:Leu-enkephalin
 cyclic_relationship: is_tautomer_of CHEBI:190689


show annotations for term's descendants           Sort by:
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions		 ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]		 CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        molecular messenger 18611
          neurotransmitter 11525
            Leu-enkephalin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  cyclic hydrocarbon 17215
                                    monocyclic hydrocarbon 6141
                                      annulene 5792
                                        aromatic annulene 5792
                                          benzene 5792
                                            alkylbenzene 3505
                                              methylbenzene 3366
                                                toluene 3238
                                                  benzyl group 2648
                                                    phenylalanine 2648
                                                      L-phenylalanine 2373
                                                        Leu-enkephalin 3
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