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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:moclobemide
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Accession:CHEBI:83531 term browser browse the term
Definition:A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
Synonyms:exact_synonym: 4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide
 related_synonym: Formula=C13H17ClN2O2;   InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17);   InChIKey=YHXISWVBGDMDLQ-UHFFFAOYSA-N;   SMILES=Clc1ccc(cc1)C(=O)NCCN1CCOCC1;   moclobemida;   moclobemidum
 xref: CAS:71320-77-9;   DrugBank:DB01171;   Drug_Central:1825;   HMDB:HMDB0015302;   KEGG:D02561;   LINCS:LSM-5247
 xref_mesh: MESH:D020912
 xref: PMID:23616181;   PMID:24859491;   PMID:24863864;   PMID:25335956;   Reaxys:530974


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moclobemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Moclobemide CTD PMID:12464242 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Maoa monoamine oxidase A decreases activity
multiple interactions		 ISO
EXP		 Moclobemide results in decreased activity of MAOA protein
Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]		 CTD PMID:15178694 PMID:15545290 PMID:21923181 PMID:23943324 PMID:26721607 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          moclobemide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                arenecarboxamide 8246
                                                  benzamides 8246
                                                    moclobemide 2
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