Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:empagliflozin
go back to main search page
Accession:CHEBI:82720 term browser browse the term
Definition:A C-glycosyl compound consisting of a beta-glucosyl residue having a (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl group at the anomeric centre. A sodium-glucose co-transporter 2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol
 related_synonym: (1S)-1,5-anhydro-1-C-{4-chloro-3-((4-{((3S)-oxolan-3-yl)oxy}phenyl)methyl)phenyl}-D-glucitol;   1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene;   BI-10773;   BI10773;   Formula=C23H27ClO7;   InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1;   InChIKey=OBWASQILIWPZMG-QZMOQZSNSA-N;   JARDIANCE;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(O[C@H]3CCOC3)cc2)c1
 xref: CAS:864070-44-0;   Drug_Central:4830;   KEGG:D10459
 xref_mesh: MESH:C570240
 xref: PMID:23859488;   PMID:23859534;   PMID:23906415;   PMID:24226524;   PMID:24491572;   PMID:24716752;   PMID:24722494;   PMID:24746173;   PMID:24766495;   PMID:24795251;   PMID:24929430;   PMID:24944269;   PMID:24948511;   PMID:24958326;   PMID:24964723;   PMID:24991224;   PMID:24993361;   PMID:25061325;   PMID:25161155;   PMID:25199997;   PMID:25260362;   PMID:25271206;   PMID:25274537;   PMID:25296258;   PMID:25301180;   Reaxys:12378768;   Wikipedia:Empagliflozin


show annotations for term's descendants           Sort by:
empagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in decreased expression of BECN1 protein] CTD PMID:35654124 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Cat catalase multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:35654124 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA] CTD PMID:35654124 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:35654124 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Elf2 E74 like ETS transcription factor 2 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in decreased expression of ELF2 mRNA] CTD PMID:35654124 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of HSPA5 protein] CTD PMID:35654124 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of IL1B protein] CTD PMID:35654124 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mir211 microRNA 211 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of MIR211 mRNA] CTD PMID:35654124 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644 		JBrowse link
G Snca synuclein alpha multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:35654124 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        inhibitor 18907
          sodium-glucose transport protein subtype 2 inhibitor 68
            empagliflozin 9
              Synjardy 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbohydrates and carbohydrate derivatives 15285
                                    carbohydrate 15285
                                      carbohydrate derivative 14290
                                        glycosyl compound 13048
                                          C-glycosyl compound 318
                                            empagliflozin 9
                                              Synjardy 0
paths to the root