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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Notopterol
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Accession:CHEBI:81136 term browser browse the term
Definition:A furanocoumarin that has formula C21H22O5.
Synonyms:related_synonym: Formula=C21H22O5;   InChI=1S/C21H22O5/c1-13(2)10-15(22)11-14(3)6-8-25-21-16-4-5-20(23)26-19(16)12-18-17(21)7-9-24-18/h4-7,9-10,12,15,22H,8,11H2,1-3H3/b14-6+;   InChIKey=BKIACVAZUKISOR-MKMNVTDBSA-N;   SMILES=CC(C)=CC(O)C\\C(C)=C\\COc1c2ccoc2cc2oc(=O)ccc12
 xref: CAS:88206-46-6;   KEGG:C17499
 xref_mesh: MESH:C082412


show annotations for term's descendants           Sort by:
Notopterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases metabolic processing
multiple interactions		 EXP CYP1A2 protein results in increased metabolism of notopterol
[CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]		 CTD PMID:32198085 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases metabolic processing
multiple interactions
decreases activity		 EXP CYP2B6 protein results in increased metabolism of notopterol
[CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; notopterol inhibits the reaction [[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion]; notopterol inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
notopterol results in decreased activity of CYP2B6 protein		 CTD PMID:32198085 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
increases metabolic processing		 EXP [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:32198085 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases metabolic processing		 EXP [CYP2C9 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:32198085 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity
multiple interactions
increases metabolic processing		 EXP notopterol results in decreased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Antioxidants inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]; NADP deficiency inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; notopterol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]		 CTD PMID:32198085 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity
increases metabolic processing
multiple interactions		 EXP notopterol results in decreased activity of CYP2E1 protein
CYP2E1 protein results in increased metabolism of notopterol
[CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; notopterol inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; notopterol inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]		 CTD PMID:32198085 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
increases metabolic processing
multiple interactions		 EXP notopterol results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of notopterol
[CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; notopterol inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; notopterol inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]		 CTD PMID:32198085 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    chemical entity 26029
      atom 26025
        nonmetal atom 25513
          oxygen atom 24821
            oxygen molecular entity 24821
              organooxygen compound 24071
                oxacycle 20033
                  furochromene 137
                    furanocoumarin 137
                      Notopterol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            organic molecule 25233
                              organic cyclic compound 24287
                                organic heterocyclic compound 22334
                                  organic heteropolycyclic compound 21328
                                    organic heterotricyclic compound 15982
                                      furochromene 137
                                        furanocoumarin 137
                                          Notopterol 7
paths to the root