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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ferruginol
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Accession:CHEBI:78274 term browser browse the term
Definition:An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.
Synonyms:exact_synonym: abieta-8,11,13-trien-12-ol
 related_synonym: 12-hydroxyabieta-8,11,13-triene;   8,11,13-abietatrien-12-ol;   Formula=C20H30O;   InChI=1S/C20H30O/c1-13(2)15-11-14-7-8-18-19(3,4)9-6-10-20(18,5)16(14)12-17(15)21/h11-13,18,21H,6-10H2,1-5H3/t18-,20+/m0/s1;   InChIKey=QXNWVJOHUAQHLM-AZUAARDMSA-N;   SMILES=CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C)c2cc1O
 alt_id: CHEBI:5045
 xref: CAS:514-62-5;   KEGG:C09092;   KNApSAcK:C00003426
 xref_mesh: MESH:C431074
 xref: MetaCyc:CPD-16534;   PMID:16202980;   PMID:18237473;   PMID:18294971;   PMID:23812755;   PMID:24417091;   PMID:24651372;   PMID:24690774;   PMID:24710900;   Reaxys:5275000;   Wikipedia:Ferruginol


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ferruginol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases activity		 ISO pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [ferruginol results in increased activity of CASP3 protein] CTD PMID:30086653 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:32946155 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein] CTD PMID:32946155 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 ISO pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased expression of RELA protein]; SB 203580 inhibits the reaction [ferruginol results in increased expression of RELA protein] CTD PMID:30086653 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein] CTD PMID:32946155 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32946155 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:32946155 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antibacterial agent 15616
            ferruginol 7
              11,20-dihydroxyferruginol + 0
              11,20-dihydroxysugiol 0
              11-hydroxyferruginol 0
              11-hydroxysugiol + 0
              6beta-hydroxyferruginol 0
              salviol 0
              sugiol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    terpenoid 13755
                                      diterpenoid 13024
                                        abietane diterpenoid 407
                                          ferruginol 7
                                            11,20-dihydroxyferruginol + 0
                                            11,20-dihydroxysugiol 0
                                            11-hydroxyferruginol 0
                                            11-hydroxysugiol + 0
                                            6beta-hydroxyferruginol 0
                                            salviol 0
                                            sugiol + 0
paths to the root