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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide
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Accession:CHEBI:77054 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively.
Synonyms:related_synonym: Formula=C22H14Cl2I2N2O2;   InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30);   InChIKey=JMPFSEBWVLAJKM-UHFFFAOYSA-N;   SMILES=Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O
 xref: LINCS:LSM-4989;   VSDB:1809


show annotations for term's descendants           Sort by:
closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
decreases response to substance		 ISO closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
ABCB1A protein results in decreased susceptibility to closantel		 CTD PMID:20513441 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G BCL3 BCL3 transcription coactivator increases expression ISO closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044 		JBrowse link
G SLC25A31 solute carrier family 25 member 31 decreases activity EXP closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 4:127,730,400...127,774,292
Ensembl chr 4:127,730,400...127,774,292 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 decreases activity EXP closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 decreases activity EXP closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396 		JBrowse link
G SLC25A6 solute carrier family 25 member 6 decreases activity EXP closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr  X:1,386,152...1,392,113
NCBI chr  Y:1,386,152...1,392,113
Ensembl chr  X:1,386,152...1,392,113
Ensembl chr  Y:1,386,152...1,392,113 		JBrowse link
G THRA thyroid hormone receptor alpha increases activity ISO closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G THRB thyroid hormone receptor beta increases activity ISO closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      group 25882
        pseudohalo group 4855
          cyano group 4855
            nitrile 4855
              N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                (R)-closantel + 8
                (S)-closantel + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbon oxoacid 22761
                                    carboxylic acid 22741
                                      carboacyl group 20058
                                        univalent carboacyl group 20058
                                          carbamoyl group 19571
                                            carboxamide 19571
                                              monocarboxylic acid amide 16962
                                                N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                                                  (R)-closantel + 8
                                                  (S)-closantel + 8
paths to the root