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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:neostigmine
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Accession:CHEBI:7514 term browser browse the term
Definition:A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium
 related_synonym: (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate;   3-Trimethylammoniumphenyl N,N-dimethylcarbamate;   Eustigmin;   Eustigmine;   Formula=C12H19N2O2;   InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1;   InChIKey=ALWKGYPQUAPLQC-UHFFFAOYSA-N;   Prostigmine;   SMILES=CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C;   Vagostigmine;   m-Trimethylammoniumphenyldimethylcarbamate
 xref: Beilstein:3615946;   CAS:59-99-4;   DrugBank:DB01400;   Drug_Central:1897;   HMDB:HMDB0015472;   KEGG:C07258;   KEGG:D08261;   LINCS:LSM-5360
 xref_mesh: MESH:D009388
 xref: PMID:7200780;   PMID:8584207;   Reaxys:3615946;   Wikipedia:Neostigmine


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neostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Neostigmine results in decreased activity of ACHE protein CTD PMID:623676 PMID:19105816 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bche butyrylcholinesterase affects response to substance ISO BCHE affects the susceptibility to Neostigmine CTD PMID:18399847 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Il10 interleukin 10 increases expression EXP Neostigmine results in increased expression of IL10 protein CTD PMID:17872965 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Pygl glycogen phosphorylase L increases activity
multiple interactions		 EXP Neostigmine results in increased activity of PYGL protein modified form
Phentolamine inhibits the reaction [Neostigmine results in increased activity of PYGL protein modified form]		 CTD PMID:1350317 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Neostigmine results in decreased expression of TNF protein CTD PMID:17872965 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      molecular entity 19842
        ion 16715
          organic ion 9898
            organic cation 8956
              quaternary ammonium ion 5287
                neostigmine 5
                  neostigmine bromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    main group molecular entity 19792
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19115
                            inorganic hydride 18121
                              pnictogen hydride 18110
                                nitrogen hydride 18017
                                  ammonium 8317
                                    ammonium ion derivative 8291
                                      quaternary ammonium ion 5287
                                        neostigmine 5
                                          neostigmine bromide 0
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