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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:parecoxib
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Accession:CHEBI:73038 term browser browse the term
Definition:An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.
Synonyms:exact_synonym: N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide
 related_synonym: Formula=C19H18N2O4S;   InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22);   InChIKey=TZRHLKRLEZJVIJ-UHFFFAOYSA-N;   N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide;   SC-69124;   SMILES=CCC(=O)NS(=O)(=O)c1ccc(cc1)-c1c(C)onc1-c1ccccc1;   parecoxibum
 xref: CAS:198470-84-7;   Drug_Central:2063;   KEGG:D02709;   LINCS:LSM-5316
 xref_mesh: MESH:C409945
 xref: PDBeChem:PXB;   Reaxys:8640266;   Wikipedia:Parecoxib


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parecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 increases expression ISO parecoxib results in increased expression of CDH1 protein CTD PMID:35917206 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases response to substance ISO CNR1 protein results in increased susceptibility to parecoxib CTD PMID:23371449 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO parecoxib results in decreased expression of CTNNB1 protein CTD PMID:35917206 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases expression		 ISO parecoxib results in decreased expression of GSK3B protein modified form
parecoxib results in increased expression of GSK3B protein		 CTD PMID:35917206 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Macc1 MET transcriptional regulator MACC1 decreases expression ISO parecoxib results in decreased expression of MACC1 protein CTD PMID:35917206 NCBI chr 6:140,352,690...140,430,255
Ensembl chr 6:140,352,755...140,430,255 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO parecoxib results in decreased phosphorylation of MAPK1 protein CTD PMID:35917206 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO parecoxib results in decreased phosphorylation of MAPK3 protein CTD PMID:35917206 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO parecoxib results in increased phosphorylation of MAPK8 protein CTD PMID:35917206 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO parecoxib results in increased phosphorylation of MAPK9 protein CTD PMID:35917206 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO parecoxib results in decreased expression of MET protein CTD PMID:35917206 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Vim vimentin decreases expression ISO parecoxib results in decreased expression of VIM protein CTD PMID:35917206 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pro-agent 11524
          prodrug 11284
            parecoxib 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  heteroarene 17117
                                    monocyclic heteroarene 14853
                                      azole 14358
                                        oxazole 3643
                                          isoxazoles 3117
                                            valdecoxib 733
                                              parecoxib 11
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