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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lorcaserin
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Accession:CHEBI:65353 term browser browse the term
Definition:A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group.
Synonyms:exact_synonym: (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
 related_synonym: Formula=C11H14ClN;   InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1;   InChIKey=XTTZERNUQAFMOF-QMMMGPOBSA-N;   SMILES=C[C@H]1CNCCc2ccc(Cl)cc12
 xref: CAS:616202-92-7;   Drug_Central:4374
 xref_mesh: MESH:C506658
 xref: Reaxys:9904422


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lorcaserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO lorcaserin results in decreased expression of CCL2 mRNA CTD PMID:36687627 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ffar4 free fatty acid receptor 4 increases expression ISO lorcaserin results in increased expression of FFAR4 mRNA CTD PMID:36687627 NCBI chr 1:235,873,576...235,891,597
Ensembl chr 1:235,873,576...235,891,597 		JBrowse link
G Il13 interleukin 13 increases expression ISO lorcaserin results in increased expression of IL13 mRNA CTD PMID:36687627 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO lorcaserin results in decreased expression of IL1B mRNA CTD PMID:36687627 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO lorcaserin results in decreased expression of IL6 mRNA CTD PMID:36687627 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO lorcaserin results in decreased expression of TNF mRNA CTD PMID:36687627 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO UGT2B17 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO UGT2B7 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          anti-obesity agent 483
            lorcaserin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterobicyclic compound 17216
                                      benzazepine 536
                                        lorcaserin 10
paths to the root