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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lomustine
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Accession:CHEBI:6520 term browser browse the term
Definition:An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.
Synonyms:related_synonym: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea;   1-(2-chloroethyl)-3-cyclohexylnitrosourea;   Belustine;   CCNU;   CINU;   Cecenu;   CeeNU;   Formula=C9H16ClN3O2;   InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14);   InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N;   N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea;   SMILES=ClCCN(N=O)C(=O)NC1CCCCC1;   chloroethylcyclohexylnitrosourea;   cyclohexyl chloroethyl nitrosourea;   lomustina;   lomustinum
 xref: CAS:13010-47-4;   DrugBank:DB01206;   Drug_Central:1596;   HMDB:HMDB0015337;   KEGG:C07079;   KEGG:D00363
 xref_mesh: MESH:D008130
 xref: PMID:12153595;   PMID:19901016;   PMID:20719460;   PMID:22577051;   PMID:24293673;   PMID:24368412;   PMID:24516018;   PMID:6762924;   Reaxys:2125058;   Wikipedia:Lomustine


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lomustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Lomustine results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Lomustine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Lomustine results in increased expression of CDKN1A mRNA; Lomustine results in increased expression of CDKN1A protein CTD PMID:24211769 PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Lomustine results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases response to substance		 ISO MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]
MGMT mRNA results in decreased susceptibility to Lomustine		 CTD PMID:15448748 PMID:16033832 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Polh DNA polymerase eta increases expression
decreases response to substance
multiple interactions		 ISO Lomustine results in increased expression of POLH mRNA; Lomustine results in increased expression of POLH protein
POLH protein results in decreased susceptibility to Lomustine
pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein]		 CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO Lomustine results in decreased expression of SOCS1 mRNA CTD PMID:17374387 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Lomustine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stmn1 stathmin 1 affects response to substance ISO STMN1 mRNA affects the susceptibility to Lomustine CTD PMID:17440165 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            antineoplastic agent 17749
              lomustine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                urea 5571
                                                  ureas 5569
                                                    N-nitrosoureas 2115
                                                      lomustine 10
paths to the root