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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
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Accession:CHEBI:64210 term browser browse the term
Definition:An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Synonyms:related_synonym: AM580;   Am 580;   CD-336;   Formula=C22H25NO3;   InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26);   InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N;   SMILES=CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
 xref: Beilstein:3565084;   CAS:102121-60-8;   KEGG:C15619;   LINCS:LSM-2132
 xref_mesh: MESH:C068073
 xref: PDB:3KMR;   PMID:18271925;   PMID:18416830;   PMID:19700416;   PMID:19790202;   PMID:20147703;   PMID:20453882;   PMID:21150871;   PMID:21310893;   PMID:21715427;   PMID:22258322;   PMID:22353356;   Reaxys:3565084


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4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700030J22Rik RIKEN cDNA 1700030J22 gene decreases expression ISO Am 580 results in decreased expression of C16ORF46 mRNA CTD PMID:16982809 NCBI chr 8:117,696,333...117,705,741
Ensembl chr 8:117,696,333...117,705,698 		JBrowse link
G 4930523C07Rik RIKEN cDNA 4930523C07 gene decreases expression ISO Am 580 results in decreased expression of KIAA0040 mRNA CTD PMID:16982809 NCBI chr 1:159,871,950...159,906,157
Ensembl chr 1:159,871,952...159,907,778 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO Am 580 promotes the reaction [Tretinoin results in increased expression of ABCG2 mRNA] CTD PMID:20562004 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Ada adenosine deaminase increases expression ISO Am 580 results in increased expression of ADA mRNA CTD PMID:16982809 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 increases expression ISO Am 580 results in increased expression of AGPAT4 mRNA CTD PMID:16982809 NCBI chr17:12,337,372...12,438,536
Ensembl chr17:12,337,591...12,438,532 		JBrowse link
G Agrn agrin decreases expression ISO Am 580 results in decreased expression of AGRN mRNA CTD PMID:16982809 NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945 		JBrowse link
G Ajap1 adherens junction associated protein 1 increases expression ISO Am 580 results in increased expression of AJAP1 mRNA CTD PMID:16982809 NCBI chr 4:153,457,678...153,568,313
Ensembl chr 4:153,457,678...153,567,268 		JBrowse link
G Aplp2 amyloid beta precursor-like protein 2 increases expression ISO Am 580 results in increased expression of APLP2 mRNA CTD PMID:16982809 NCBI chr 9:31,060,853...31,123,144
Ensembl chr 9:31,060,853...31,123,111 		JBrowse link
G Ar androgen receptor decreases activity ISO Am 580 results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 decreases expression ISO Am 580 results in decreased expression of ATP2B1 mRNA CTD PMID:16982809 NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005 		JBrowse link
G Bag2 BCL2-associated athanogene 2 increases expression ISO Am 580 results in increased expression of BAG2 mRNA CTD PMID:16982809 NCBI chr 1:33,784,565...33,796,831
Ensembl chr 1:33,784,565...33,796,876 		JBrowse link
G Calcrl calcitonin receptor-like decreases expression ISO Am 580 results in decreased expression of CALCRL mRNA CTD PMID:16982809 NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755 		JBrowse link
G Capn1 calpain 1 decreases expression
decreases activity		 EXP Am 580 results in decreased expression of CAPN1 mRNA
Am 580 results in decreased activity of CAPN1 protein		 CTD PMID:17460283 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Capn2 calpain 2 decreases expression
decreases activity
multiple interactions		 EXP Am 580 results in decreased expression of CAPN2 mRNA
Am 580 results in decreased activity of CAPN2 protein
Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]; Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]		 CTD PMID:17460283 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Cd1d1 CD1d1 antigen increases expression
multiple interactions		 ISO Am 580 results in increased expression of CD1D mRNA
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]		 CTD PMID:16982809 PMID:17392484 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd300a CD300A molecule increases expression ISO Am 580 results in increased expression of CD300A mRNA CTD PMID:16982809 NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480 		JBrowse link
G Cd300lb CD300 molecule like family member B increases expression ISO Am 580 results in increased expression of CD300LB mRNA CTD PMID:16982809 NCBI chr11:114,813,605...114,825,197
Ensembl chr11:114,813,607...114,825,212 		JBrowse link
G Cd300lf CD300 molecule like family member F increases expression ISO Am 580 results in increased expression of CD300LF mRNA CTD PMID:16982809 NCBI chr11:115,007,040...115,024,834
Ensembl chr11:115,007,040...115,024,818 		JBrowse link
G Cd38 CD38 antigen increases expression
multiple interactions		 ISO Am 580 results in increased expression of CD38 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]; [Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein		 CTD PMID:16329108 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B affects localization ISO Am 580 affects the localization of CDKN1B protein CTD PMID:16618747 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdr2l cerebellar degeneration-related protein 2-like decreases expression ISO Am 580 results in decreased expression of CDR2L mRNA CTD PMID:16982809 NCBI chr11:115,272,700...115,286,961
Ensembl chr11:115,272,742...115,286,958 		JBrowse link
G Col5a3 collagen, type V, alpha 3 increases expression ISO Am 580 results in increased expression of COL5A3 mRNA CTD PMID:16982809 NCBI chr 9:20,681,353...20,726,363
Ensembl chr 9:20,681,346...20,726,363 		JBrowse link
G Cttnbp2 cortactin binding protein 2 decreases expression ISO Am 580 results in decreased expression of CTTNBP2 mRNA CTD PMID:16982809 NCBI chr 6:18,366,470...18,515,216
Ensembl chr 6:18,366,477...18,514,842 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Am 580 results in increased expression of CYP19A1 mRNA CTD PMID:15941851 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] CTD PMID:10953040 NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein increases expression ISO Am 580 results in increased expression of DCSTAMP mRNA CTD PMID:16982809 NCBI chr15:39,609,326...39,624,334
Ensembl chr15:39,609,326...39,624,334 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Am 580 results in increased expression of DHRS3 mRNA CTD PMID:16982809 NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779 		JBrowse link
G Dmpk dystrophia myotonica-protein kinase decreases expression ISO Am 580 results in decreased expression of DMPK mRNA CTD PMID:16982809 NCBI chr 7:18,817,571...18,827,746
Ensembl chr 7:18,817,774...18,827,746 		JBrowse link
G Dmwd dystrophia myotonica-containing WD repeat motif decreases expression ISO Am 580 results in decreased expression of DMWD mRNA CTD PMID:16982809 NCBI chr 7:18,810,002...18,816,701
Ensembl chr 7:18,810,152...18,816,701 		JBrowse link
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta increases expression ISO Am 580 results in increased expression of DNAJC5B mRNA CTD PMID:16982809 NCBI chr 3:19,562,755...19,665,026
Ensembl chr 3:19,562,759...19,665,026 		JBrowse link
G Ets2 E26 avian leukemia oncogene 2, 3' domain increases expression ISO Am 580 results in increased expression of ETS2 mRNA CTD PMID:16982809 NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095 		JBrowse link
G Fam241a family with sequence similarity 241, member A decreases expression ISO Am 580 results in decreased expression of FAM241A mRNA CTD PMID:16982809 NCBI chr 3:127,663,337...127,689,972
Ensembl chr 3:127,662,707...127,689,973 		JBrowse link
G Fas Fas cell surface death receptor increases activity ISO Am 580 results in increased activity of FAS protein CTD PMID:15703382 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Am 580 results in increased expression of FN1 mRNA CTD PMID:16982809 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Am 580 results in decreased expression of FUT7 mRNA CTD PMID:16982809 NCBI chr 2:25,312,363...25,316,386
Ensembl chr 2:25,313,279...25,316,386 		JBrowse link
G Galm galactose mutarotase increases expression ISO Am 580 results in increased expression of GALM mRNA CTD PMID:18052213 NCBI chr17:80,434,886...80,492,461
Ensembl chr17:80,434,900...80,492,530 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Am 580 results in increased expression of GDF15 mRNA CTD PMID:16982809 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like decreases expression ISO Am 580 results in decreased expression of GPD1L mRNA CTD PMID:16982809 NCBI chr 9:114,728,407...114,763,055
Ensembl chr 9:114,728,409...114,763,055 		JBrowse link
G Gusb glucuronidase, beta increases expression ISO Am 580 results in increased expression of GUSB mRNA CTD PMID:16982809 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G H2bc14 H2B clustered histone 14 decreases expression ISO Am 580 results in decreased expression of H2BC5 mRNA CTD PMID:16982809 NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO Am 580 results in increased expression of HIPK2 mRNA CTD PMID:16982809 NCBI chr 6:38,664,447...38,853,236
Ensembl chr 6:38,671,325...38,853,099 		JBrowse link
G Hlx H2.0-like homeobox decreases expression ISO Am 580 results in decreased expression of HLX mRNA CTD PMID:16982809 NCBI chr 1:184,459,340...184,464,690
Ensembl chr 1:184,459,337...184,464,816 		JBrowse link
G Ifngr1 interferon gamma receptor 1 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] CTD PMID:16085646 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Il1r1 interleukin 1 receptor, type I decreases expression ISO Am 580 results in decreased expression of IL1R1 mRNA CTD PMID:16982809 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein decreases expression ISO Am 580 results in decreased expression of IL1RAP mRNA CTD PMID:16982809 NCBI chr16:26,400,259...26,548,878
Ensembl chr16:26,400,454...26,548,867 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression ISO Am 580 results in increased expression of INPP5F mRNA CTD PMID:16982809 NCBI chr 7:128,212,905...128,298,161
Ensembl chr 7:128,213,052...128,298,149 		JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Am 580 results in decreased expression of IPCEF1 mRNA CTD PMID:16982809 NCBI chr10:6,835,779...6,973,185
Ensembl chr10:6,835,796...7,002,478 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions
increases activity
increases expression		 ISO Am 580 affects the localization of [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Tretinoin promotes the reaction [Am 580 results in increased activity of IRF1 protein] CTD PMID:16085646 PMID:16636311 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Itgae integrin alpha E, epithelial-associated increases expression ISO Am 580 results in increased expression of ITGAE mRNA CTD PMID:16982809 NCBI chr11:72,981,396...73,038,272
Ensembl chr11:72,981,409...73,038,272 		JBrowse link
G Kifc2 kinesin family member C2 decreases expression ISO Am 580 results in decreased expression of KIFC2 mRNA CTD PMID:16982809 NCBI chr15:76,543,984...76,552,396
Ensembl chr15:76,544,058...76,552,396 		JBrowse link
G Lair1 leukocyte-associated Ig-like receptor 1 increases expression ISO Am 580 results in increased expression of LAIR1 mRNA CTD PMID:16982809 NCBI chr 7:4,010,072...4,076,566
Ensembl chr 7:4,006,401...4,066,178 		JBrowse link
G Lelp1 late cornified envelope-like proline-rich 1 decreases expression ISO Am 580 results in decreased expression of LELP1 mRNA CTD PMID:16982809 NCBI chr 3:92,042,301...92,050,061
Ensembl chr 3:92,042,304...92,050,051 		JBrowse link
G Lrp11 low density lipoprotein receptor-related protein 11 decreases expression ISO Am 580 results in decreased expression of LRP11 mRNA CTD PMID:16982809 NCBI chr10:7,465,532...7,501,247
Ensembl chr10:7,465,564...7,501,247 		JBrowse link
G Man1c1 mannosidase, alpha, class 1C, member 1 decreases expression ISO Am 580 results in decreased expression of MAN1C1 mRNA CTD PMID:16982809 NCBI chr 4:134,289,001...134,432,987
Ensembl chr 4:134,289,001...134,431,601 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 decreases expression ISO Am 580 results in decreased expression of MAP3K6 mRNA CTD PMID:16982809 NCBI chr 4:132,965,290...132,980,240
Ensembl chr 4:132,968,129...132,980,240 		JBrowse link
G Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 decreases expression ISO Am 580 results in decreased expression of MAP4K1 mRNA CTD PMID:16982809 NCBI chr 7:28,681,506...28,702,704
Ensembl chr 7:28,681,475...28,702,704 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Am 580 co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator decreases expression ISO Am 580 results in decreased expression of METRN mRNA CTD PMID:16982809 NCBI chr17:26,013,545...26,016,019
Ensembl chr17:26,012,195...26,016,057 		JBrowse link
G Mgat4c MGAT4 family, member C decreases expression ISO Am 580 results in decreased expression of MGAT4C mRNA CTD PMID:16982809 NCBI chr10:101,517,348...102,227,712
Ensembl chr10:101,517,348...102,227,330 		JBrowse link
G Myorg myogenesis regulating glycosidase (putative) decreases expression ISO Am 580 results in decreased expression of MYORG mRNA CTD PMID:16982809 NCBI chr 4:41,495,601...41,503,132
Ensembl chr 4:41,495,604...41,503,076 		JBrowse link
G Ndrg2 N-myc downstream regulated gene 2 decreases expression ISO Am 580 results in decreased expression of NDRG2 mRNA CTD PMID:16982809 NCBI chr14:52,142,738...52,151,463
Ensembl chr14:52,142,728...52,151,615 		JBrowse link
G Nphs1 nephrosis 1, nephrin increases expression EXP Am580 increases expression of Nphs1 mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity		 ISO Am 580 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Am 580 results in increased activity of NR1H4 protein		 CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Am 580 results in increased expression of NRIP1 mRNA CTD PMID:16982809 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression ISO Am 580 results in increased expression of NRIP3 mRNA CTD PMID:16982809 NCBI chr 7:109,357,263...109,380,752
Ensembl chr 7:109,357,262...109,381,232 		JBrowse link
G Nudt7 nudix hydrolase 7 decreases expression ISO Am 580 results in decreased expression of NUDT7 mRNA CTD PMID:16982809 NCBI chr 8:114,860,314...114,881,471
Ensembl chr 8:114,860,297...114,881,479 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 multiple interactions
increases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA] CTD PMID:16636311 NCBI chr 5:120,868,398...120,887,949
Ensembl chr 5:120,868,398...120,887,918 		JBrowse link
G Ocln occludin increases expression ISO Am 580 results in increased expression of OCLN mRNA CTD PMID:16982755 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO Am 580 results in increased expression of OLR1 mRNA CTD PMID:16982809 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase increases expression ISO Am 580 results in increased expression of OMA1 mRNA CTD PMID:16982809 NCBI chr 4:103,170,991...103,229,066
Ensembl chr 4:103,171,009...103,229,065 		JBrowse link
G Pald1 phosphatase domain containing, paladin 1 decreases expression ISO Am 580 results in decreased expression of PALD1 mRNA CTD PMID:16982809 NCBI chr10:61,155,435...61,219,325
Ensembl chr10:61,155,435...61,219,309 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Am 580 results in increased expression of PAPSS2 mRNA CTD PMID:16982809 NCBI chr19:32,573,072...32,644,587
Ensembl chr19:32,573,190...32,644,587 		JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Am 580 results in decreased expression of PDLIM2 mRNA CTD PMID:16982809 NCBI chr14:70,401,667...70,415,140
Ensembl chr14:70,401,667...70,415,130 		JBrowse link
G Pdlim4 PDZ and LIM domain 4 decreases expression ISO Am 580 results in decreased expression of PDLIM4 mRNA CTD PMID:16982809 NCBI chr11:53,945,754...53,959,814
Ensembl chr11:53,945,754...53,959,840 		JBrowse link
G Pheta1 PH domain containing endocytic trafficking adaptor 1 decreases expression ISO Am 580 results in decreased expression of PHETA1 mRNA CTD PMID:16982809 NCBI chr 5:121,987,060...121,992,667
Ensembl chr 5:121,987,047...121,992,695 		JBrowse link
G Phlda2 pleckstrin homology like domain, family A, member 2 decreases expression ISO Am 580 results in decreased expression of PHLDA2 mRNA CTD PMID:16982809 NCBI chr 7:143,055,282...143,056,882
Ensembl chr 7:143,055,282...143,056,887 		JBrowse link
G Plbd1 phospholipase B domain containing 1 increases expression ISO Am 580 results in increased expression of PLBD1 mRNA CTD PMID:16982809 NCBI chr 6:136,589,069...136,639,301
Ensembl chr 6:136,589,068...136,638,926 		JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression ISO Am 580 results in increased expression of PLPP3 mRNA CTD PMID:16982809 NCBI chr 4:105,014,544...105,089,964
Ensembl chr 4:105,014,544...105,089,961 		JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Am 580 results in decreased expression of PON2 mRNA CTD PMID:16982809 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455 		JBrowse link
G Pram1 PML-RAR alpha-regulated adaptor molecule 1 increases expression ISO Am 580 results in increased expression of PRAM1 mRNA CTD PMID:16982809 NCBI chr17:33,857,030...33,864,680
Ensembl chr17:33,857,030...33,864,680 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase decreases expression ISO Am 580 results in decreased expression of QPRT mRNA CTD PMID:16982809 NCBI chr 7:126,706,942...126,721,201
Ensembl chr 7:126,706,286...126,721,398 		JBrowse link
G Rab15 RAB15, member RAS oncogene family decreases expression ISO Am 580 results in decreased expression of RAB15 mRNA CTD PMID:16982809 NCBI chr12:76,844,734...76,869,532
Ensembl chr12:76,844,734...76,869,682 		JBrowse link
G Rab20 RAB20, member RAS oncogene family increases expression ISO Am 580 results in increased expression of RAB20 mRNA CTD PMID:16982809 NCBI chr 8:11,503,390...11,528,640
Ensembl chr 8:11,503,518...11,528,710 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein decreases expression ISO Am 580 results in decreased expression of RAP1GAP mRNA CTD PMID:16982809 NCBI chr 4:137,391,549...137,457,172
Ensembl chr 4:137,392,037...137,457,172 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression
multiple interactions
decreases expression		 ISO Am 580 results in increased expression of RARA protein
2-bromopalmitate inhibits the reaction [Am 580 results in decreased expression of RARA protein]; Am 580 binds to and results in increased activity of RARA protein; Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]		 CTD PMID:10779427 PMID:16178010 PMID:16636311 PMID:17290005 PMID:30076181 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [Am 580 co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbp1 retinol binding protein 1, cellular increases expression ISO Am 580 results in increased expression of RBP1 mRNA CTD PMID:16982809 NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628 		JBrowse link
G Reps2 RALBP1 associated Eps domain containing protein 2 decreases expression ISO Am 580 results in decreased expression of REPS2 mRNA CTD PMID:16982809 NCBI chr  X:161,194,949...161,426,701
Ensembl chr  X:161,194,950...161,426,645 		JBrowse link
G Rflnb refilin B increases expression ISO Am 580 results in increased expression of RFLNB mRNA CTD PMID:16982809 NCBI chr11:75,910,020...75,918,608
Ensembl chr11:75,910,020...75,918,608 		JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Am 580 results in decreased expression of RFXAP mRNA CTD PMID:16982809 NCBI chr 3:54,710,536...54,715,212
Ensembl chr 3:54,710,536...54,715,212 		JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 increases expression ISO Am 580 results in increased expression of RHOBTB3 mRNA CTD PMID:16982809 NCBI chr13:76,017,656...76,092,054
Ensembl chr13:76,017,656...76,092,044 		JBrowse link
G Rxra retinoid X receptor alpha increases activity ISO Am 580 results in increased activity of RXRA protein CTD PMID:21543282 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Sel1l3 sel-1 suppressor of lin-12-like 3 (C. elegans) increases expression ISO Am 580 results in increased expression of SEL1L3 mRNA CTD PMID:16982809 NCBI chr 5:53,264,425...53,370,794
Ensembl chr 5:53,264,425...53,371,269 		JBrowse link
G Selplg selectin, platelet (p-selectin) ligand decreases expression ISO Am 580 results in decreased expression of SELPLG mRNA CTD PMID:16982809 NCBI chr 5:113,955,859...113,970,576
Ensembl chr 5:113,956,597...113,970,705 		JBrowse link
G Slc26a11 solute carrier family 26, member 11 increases expression ISO Am 580 results in increased expression of SLC26A11 mRNA CTD PMID:16982809 NCBI chr11:119,246,328...119,271,902
Ensembl chr11:119,246,383...119,271,905 		JBrowse link
G Slitrk4 SLIT and NTRK-like family, member 4 increases expression ISO Am 580 results in increased expression of SLITRK4 mRNA CTD PMID:16982809 NCBI chr  X:63,308,489...63,320,951
Ensembl chr  X:63,308,491...63,320,602 		JBrowse link
G Snai3 snail family zinc finger 3 increases expression ISO Am 580 results in increased expression of SNAI3 mRNA CTD PMID:16982809 NCBI chr 8:123,180,943...123,187,546
Ensembl chr 8:123,180,947...123,187,472 		JBrowse link
G Ssmem1 serine-rich single-pass membrane protein 1 decreases expression ISO Am 580 results in decreased expression of SSMEM1 mRNA CTD PMID:16982809 NCBI chr 6:30,509,790...30,520,253
Ensembl chr 6:30,509,848...30,520,253 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein; Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:16085646 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stra6 stimulated by retinoic acid gene 6 increases expression ISO Am580 increases expression of Stra6 mRNA in lung RGD PMID:28734946 RGD:155631297 NCBI chr 9:57,971,076...58,061,287
Ensembl chr 9:57,971,071...58,061,279 		JBrowse link
G Sts steroid sulfatase increases activity ISO Am 580 results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924 		JBrowse link
G Synpo synaptopodin increases expression EXP AM580 increases expression of Synpo mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr18:60,727,053...60,793,241
Ensembl chr18:60,727,045...60,793,214 		JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO Am 580 results in decreased expression of TACSTD2 mRNA CTD PMID:16982809 NCBI chr 6:67,511,043...67,512,806
Ensembl chr 6:67,511,046...67,512,780 		JBrowse link
G Tbc1d2 TBC1 domain family, member 2 increases expression ISO Am 580 results in increased expression of TBC1D2 mRNA CTD PMID:16982809 NCBI chr 4:46,604,390...46,650,396
Ensembl chr 4:46,604,390...46,650,209 		JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked decreases expression ISO Am 580 results in decreased expression of TBL1X mRNA CTD PMID:16982809 NCBI chr  X:76,553,053...76,706,591
Ensembl chr  X:76,554,619...76,706,589 		JBrowse link
G Tbl2 transducin (beta)-like 2 increases expression ISO Am 580 results in increased expression of TBL2 mRNA CTD PMID:16982809 NCBI chr 5:135,178,288...135,192,727
Ensembl chr 5:135,178,511...135,194,614 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA CTD PMID:16482212 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tgm2 transglutaminase 2, C polypeptide multiple interactions
increases expression
increases activity		 ISO [Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein
Am 580 results in increased expression of TGM2 mRNA
Am 580 results in increased activity of TGM2 protein		 CTD PMID:2884032 PMID:9516142 PMID:16982809 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356 		JBrowse link
G Thbs3 thrombospondin 3 increases expression ISO Am 580 results in increased expression of THBS3 mRNA CTD PMID:16982809 NCBI chr 3:89,122,470...89,134,148
Ensembl chr 3:89,122,487...89,134,144 		JBrowse link
G Tmem14a transmembrane protein 14A decreases expression ISO Am 580 results in decreased expression of TMEM14A mRNA CTD PMID:16982809 NCBI chr 1:21,236,609...21,300,391
Ensembl chr 1:21,288,799...21,300,391 		JBrowse link
G Tnf tumor necrosis factor increases activity ISO Am 580 results in increased activity of TNF protein CTD PMID:15703382 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases activity ISO Am 580 results in increased activity of TNFSF10 protein CTD PMID:15703382 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12 decreases expression ISO Am 580 results in decreased expression of TNFSF12 mRNA CTD PMID:16982809 NCBI chr11:69,577,066...69,586,924
Ensembl chr11:69,577,076...69,586,675 		JBrowse link
G Tns1 tensin 1 decreases expression ISO Am 580 results in decreased expression of TNS1 mRNA CTD PMID:16982809 NCBI chr 1:73,949,391...74,163,707
Ensembl chr 1:73,949,390...74,163,608 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B decreases expression ISO Am 580 results in decreased expression of ZBTB7B mRNA CTD PMID:16982809 NCBI chr 3:89,284,953...89,300,976
Ensembl chr 3:89,284,951...89,302,083 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      application 21776
        pharmaceutical 21190
          drug 21190
            antineoplastic agent 18894
              4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 116
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            heteroorganic entity 21512
                              organochalcogen compound 21001
                                organooxygen compound 20845
                                  carbon oxoacid 19638
                                    carboxylic acid 19631
                                      carboacyl group 18297
                                        univalent carboacyl group 18297
                                          carbamoyl group 18111
                                            carboxamide 18111
                                              monocarboxylic acid amide 15838
                                                amidobenzoic acid 141
                                                  4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid 116
paths to the root