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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorphenamine
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Accession:CHEBI:52010 term browser browse the term
Definition:A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Synonyms:exact_synonym: 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
 related_synonym: 1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine;   1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane;   2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine;   3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine;   Chlorphenamin;   Chlorpheniramine;   Clofeniramina;   Formula=C16H19ClN2;   Haynon;   InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3;   InChIKey=SOYKEARSMXGVTM-UHFFFAOYSA-N;   SMILES=CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1;   chlorophenylpyridamine;   chlorphenaminum;   chlorpheniraminum;   clorfenamina;   clorfeniramina;   gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine;   gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
 alt_id: CHEBI:3644;   CHEBI:52008
 xref: Beilstein:87362;   CAS:132-22-9;   DrugBank:DB01114;   Drug_Central:616;   HMDB:HMDB0001944;   KEGG:C06905;   KEGG:D07398;   LINCS:LSM-1263
 xref_mesh: MESH:D002744
 xref: PMID:10796091;   PMID:11284026;   PMID:16119587;   PMID:16413139;   Patent:US2567245;   Patent:US2676964;   Patent:US2766174;   Reaxys:87362;   Wikipedia:Chlorpheniramine


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chlorphenamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Chlorpheniramine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Chlorpheniramine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases response to substance ISO CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine CTD PMID:17089107 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases activity		 ISO
EXP		 Chlorpheniramine binds to and results in decreased activity of HRH1 protein
Chlorpheniramine results in decreased activity of HRH1 protein
Chlorpheniramine binds to and results in decreased activity of HRH1 protein; Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]
Chlorpheniramine binds to and results in decreased activity of HRH1 protein; Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]		 CTD PMID:8111568 PMID:11432448 PMID:12128009 PMID:14569158 PMID:15054595 More... NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine] CTD PMID:14569158 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO Chlorpheniramine results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19075512 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
affects activity		 ISO Chlorpheniramine results in decreased activity of KCNH2 protein
Chlorpheniramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Chlorpheniramine affects the activity of KCNH2 protein		 CTD PMID:16278312 PMID:19885040 PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mpo myeloperoxidase decreases activity
multiple interactions		 EXP Chlorpheniramine results in decreased activity of MPO protein
Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]		 CTD PMID:16437673 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein] CTD PMID:17622767 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Chlorpheniramine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Chlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP
ISO		 Chlorpheniramine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Chlorpheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]		 CTD PMID:12440152 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
dexchlorpheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO dexchlorpheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          antagonist 17216
            histamine antagonist 4891
              chlorphenamine 14
                dexchlorpheniramine 1
                levochlorpheniramine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        tertiary amino compound 10131
                                          chlorphenamine 14
                                            dexchlorpheniramine 1
                                            levochlorpheniramine 0
paths to the root