CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: epinastine
Accession: CHEBI:51032
browse the term
Definition: A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Synonyms: exact_synonym: 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
related_synonym: 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine; Formula=C16H15N3; InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18); InChIKey=WHWZLSFABNNENI-UHFFFAOYSA-N; SMILES=NC1=NCC2N1c1ccccc1Cc1ccccc21; epinastina; epinastinum
xref: Beilstein:3593307; CAS:80012-43-7; DrugBank:DB00751; Drug_Central:1027; KEGG:D07900
xref_mesh: MESH:C053090
xref: Patent:GB2071095; Patent:US4313931; Reaxys:3593307; Wikipedia:Epinastine
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Abcb1a
ATP binding cassette subfamily B member 1A
affects transport
ISO
ABCB1A affects the transport of epinastine
CTD
PMID:15100174
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
affects transport
ISO
ABCB1B affects the transport of epinastine
CTD
PMID:15100174
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Hrh1
histamine receptor H 1
multiple interactions
EXP
[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]
CTD
PMID:12832840 PMID:19075512
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Ifng
interferon gamma
multiple interactions
ISO
epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
CTD
PMID:16534218
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il13
interleukin 13
decreases expression
ISO
epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein
CTD
PMID:16534218
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il4
interleukin 4
multiple interactions
ISO EXP
epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
CTD
PMID:16534218 PMID:19075512
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5
interleukin 5
decreases expression
ISO
epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein
CTD
PMID:16534218
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Il6
interleukin 6
decreases expression
ISO
epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein
CTD
PMID:16534218
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
epinastine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Ngf
nerve growth factor
decreases expression
ISO
epinastine results in decreased expression of NGF protein
CTD
PMID:19937255
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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