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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tranexamic acid
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Accession:CHEBI:48669 term browser browse the term
Definition:A monocarboxylic acid that has formula C8H15NO2.
Synonyms:related_synonym: Cyklokapron;   Formula=C8H15NO2;   InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-;   InChIKey=GYDJEQRTZSCIOI-LJGSYFOKSA-N;   SMILES=NC[C@H]1CC[C@@H](CC1)C(O)=O;   TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID;   Tranexamsaeure;   Tranhexamic acid;   acide tranexamique;   acido tranexamico;   acidum tranexamicum;   tranexmic acid;   trans-4-(aminomethyl)cyclohexanecarboxylic acid;   trans-Amcha;   trans-Tranexamic acid
 alt_id: CHEBI:32252;   CHEBI:40715;   CHEBI:48421
 xref: Beilstein:2207452;   CAS:1197-18-8;   DrugBank:DB00302;   Drug_Central:2713;   KEGG:D01136
 xref_mesh: MESH:D014148
 xref: PDBeChem:AMH;   Patent:NL6503605;   Patent:US3499925;   Wikipedia:Tranexamic_Acid


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tranexamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased expression of BAX protein] CTD PMID:19539006 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:19539006 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:19539006 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:19539006 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA] CTD PMID:24633426 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Krt19 keratin 19 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT19 protein] CTD PMID:24633426 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19539006 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA] CTD PMID:24633426 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA] CTD PMID:24633426 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      application 19663
        pharmaceutical 19504
          drug 19504
            hematologic agent 4954
              tranexamic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      monocarboxylic acid 18004
                                        cyclohexanecarboxylic acid 9
                                          tranexamic acid 9
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