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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dofetilide
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Accession:CHEBI:4681 term browser browse the term
Definition:A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug.
Synonyms:exact_synonym: N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
 related_synonym: Formula=C19H27N3O5S2;   InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3;   InChIKey=IXTMWRCNAAVVAI-UHFFFAOYSA-N;   SMILES=CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1;   Tikosyn;   beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;   dofetilida;   dofetilidum
 xref: CAS:115256-11-6;   DrugBank:DB00204;   Drug_Central:942;   KEGG:C07751;   KEGG:D00647;   LINCS:LSM-5925
 xref_mesh: MESH:C063533
 xref: PMID:11326815;   PMID:25620152;   PMID:25626340;   Patent:EP245997;   Patent:US4959366;   Reaxys:3572833;   Wikipedia:Dofetilide


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dofetilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions EXP dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein] CTD PMID:20723002 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects binding
decreases activity		 ISO [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 protein; Acids inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]; dofetilide binds to and results in decreased activity of KCNH2 protein; dofetilide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium affects the reaction [dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]]; Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium promotes the reaction [dofetilide binds to KCNH2 protein] CTD PMID:9395068 PMID:10828461 PMID:15272206 PMID:15821840 PMID:15961988 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein] CTD PMID:20723002 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein] CTD PMID:20723002 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            cardiovascular drug 8613
              anti-arrhythmia drug 1532
                dofetilide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                chalcogen oxoacid 13754
                                  sulfur oxoacid 13542
                                    sulfonic acid 11577
                                      sulfonic acid derivative 11577
                                        sulfonamide 5287
                                          dofetilide 4
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