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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,6-EET
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Accession:CHEBI:34450 term browser browse the term
Definition:An EET obtained by formal epoxidation of the 5,6-double bond of arachidonic acid.
Synonyms:exact_synonym: 4-{3-[(2Z,5Z,8Z)-tetradeca-2,5,8-trien-1-yl]oxiran-2-yl}butanoic acid
 related_synonym: (8Z,11Z,14Z)-5,6-Epoxyeicosa-8,11,14-trienoic acid;   (8Z,11Z,14Z)-5,6-Epoxyicosa-8,11,14-trienoic acid;   5,6-EpETrE;   5,6-Epoxy-8,11,14-eicosatrienoic acid;   5,6-epoxy-8,11,14-icosatrienoic acid;   5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid;   5,6-epoxy-8Z,11Z,14Z-icosatrienoic acid;   Formula=C20H32O3;   InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-;   InChIKey=VBQNSZQZRAGRIX-QNEBEIHSSA-N;   SMILES=CCCCC\\C=C/C\\C=C/C\\C=C/CC1OC1CCCC(O)=O
 alt_id: CHEBI:63973
 xref: CAS:81246-84-6;   HMDB:HMDB0002190;   KEGG:C14768;   LIPID_MAPS_instance:LMFA03080002
 xref_mesh: MESH:C040776
 xref: Reaxys:4498036
 cyclic_relationship: is_conjugate_acid_of CHEBI:131992


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5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis		 ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        biochemical role 19525
          metabolite 19512
            EET 13
              5,6-EET 2
                5,6-epoxy-(8Z,11Z,14Z)-icosatrienoyl-CoA 0
                N-[(8Z,11Z,14Z)-5,6-epoxyicosatrienoyl]ethanolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      monocarboxylic acid 18004
                                        fatty acid 16812
                                          unsaturated fatty acid 1099
                                            polyunsaturated fatty acid 839
                                              fatty acid 20:4 361
                                                icosatetraenoic acid 361
                                                  icosa-5,8,11,14-tetraenoic acid 318
                                                    arachidonic acid 318
                                                      EET 13
                                                        5,6-EET 2
                                                          5,6-epoxy-(8Z,11Z,14Z)-icosatrienoyl-CoA 0
                                                          N-[(8Z,11Z,14Z)-5,6-epoxyicosatrienoyl]ethanolamine 0
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