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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolvaptan
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Accession:CHEBI:32246 term browser browse the term
Definition:A benzazepine derivative incorporating a benzenedicarboxamide function whch is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. Tolvaptan is a racemate consisting of a 1:1 mixture of 5R and 5S stereomers.
Synonyms:exact_synonym: N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
 related_synonym: Formula=C26H25ClN2O3;   InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31);   InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N;   OPC 41061;   SMILES=CC1=CC=CC=C1C(=O)NC1=CC(C)=C(C=C1)C(=O)N1CCCC(O)C2=CC(Cl)=CC=C12;   jinarc;   samsca
 xref: CAS:150683-30-0;   Drug_Central:4110;   KEGG:C12613;   KEGG:D01213
 xref_mesh: MESH:C116664
 xref: PMID:12742979;   PMID:16211205;   PMID:33078835;   PMID:34070416;   PMID:34386666;   PMID:34476570;   PMID:34514204;   PMID:34526469;   PMID:34554640;   Wikipedia:Tolvaptan


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tolvaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCB11 protein; tolvaptan results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:26507107 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC2 protein CTD PMID:26507107 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC3 protein CTD PMID:26507107 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC4 protein CTD PMID:26507107 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Alb albumin decreases expression ISO Tolvaptan results in decreased expression of ALB protein CTD PMID:33022361 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Mir122 microRNA 122 increases export ISO tolvaptan results in increased export of MIR122 CTD PMID:29029277 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO tolvaptan metabolite results in decreased activity of SLC10A1 protein CTD PMID:26507107 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO tolvaptan results in increased expression of SLPI mRNA; tolvaptan results in increased expression of SLPI protein CTD PMID:28115652 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 multiple interactions ISO Cyclosporine promotes the reaction [SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan]; SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan CTD PMID:26660633 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            diuretic 4106
              aquaretic 17
                tolvaptan 11
                  DM-4103 0
                  DM-4107 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              dicarboxylic acid amide 3155
                                                dicarboxylic acid diamide 2702
                                                  benzenedicarboxamide 69
                                                    tolvaptan 11
                                                      DM-4103 0
                                                      DM-4107 0
paths to the root