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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nimetazepam
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Accession:CHEBI:31912 term browser browse the term
Definition:A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia.
Synonyms:related_synonym: 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   1-methylnitrazepam;   Dormalon;   Erimin;   Formula=C16H13N3O3;   InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3;   InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N;   Ro 5-3453;   SMILES=CN1c2ccc(cc2C(=NCC1=O)c1ccccc1)[N+]([O-])=O;   methylnitrazepam;   nimetazepamum
 xref: CAS:2011-67-8;   Drug_Central:1936;   KEGG:D01593;   LINCS:LSM-5785
 xref_mesh: MESH:C002714
 xref: PMID:1154804;   PMID:1274372;   PMID:2241855;   PMID:23085494;   PMID:23245766;   PMID:6151222;   PMID:7452466;   Patent:DE1816046;   Patent:US3109843;   Patent:US3121114;   Patent:US3141890;   Patent:US3144439;   Patent:US3203990;   Patent:US3243427;   Reaxys:759813;   Wikipedia:Nimetazepam


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nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam CTD PMID:19005028 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biophysical role 14037
          membrane transport modulator 13879
            GABA modulator 5105
              nimetazepam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organonitrogen heterocyclic compound 18126
                                    benzodiazepine 912
                                      1,4-benzodiazepinone 125
                                        nitrazepam 8
                                          nimetazepam 4
paths to the root