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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bradykinin
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Accession:CHEBI:3165 term browser browse the term
Definition:A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
Synonyms:related_synonym: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg;   BK;   Formula=C50H73N15O11;   InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1;   InChIKey=QXZGBUJJYSLZLT-FDISYFBBSA-N;   L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg;   L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine;   L-bradykinin;   RPPGFSPFR;   SMILES=N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
 xref: CAS:58-82-2
 xref_mesh: MESH:D001920
 xref: PMID:11799074;   PMID:11975815;   PMID:13446366;   PMID:13811230;   PMID:14597148;   PMID:15105283;   PMID:16680069;   PMID:18127230;   PMID:27318425;   PMID:27328010;   PMID:27432758;   PMID:27445816;   PMID:7859389;   PMID:8723398;   PMID:9403361;   Reaxys:24162492;   Reaxys:2801232;   Wikipedia:Bradykinin
 cyclic_relationship: is_conjugate_base_of CHEBI:132988


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bradykinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos3 nitric oxide synthase 3 decreases expression ISO Bradykinin results in decreased expression of NOS3 mRNA CTD PMID:24839774 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      group 19800
        organic group 18937
          amino-acid residue 11128
            peptide 11128
              oligopeptide 1343
                bradykinin 1
                  NPC-567 0
                  [Hyp(3)]-bradykinin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17554
                                            carboxamide 17554
                                              peptide 11128
                                                oligopeptide 1343
                                                  bradykinin 1
                                                    NPC-567 0
                                                    [Hyp(3)]-bradykinin 0
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