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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:crotamiton
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Accession:CHEBI:31439 term browser browse the term
Definition:An enamide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporates from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred.
Synonyms:exact_synonym: N-ethyl-N-(2-methylphenyl)but-2-enamide
 related_synonym: Formula=C13H17NO;   InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3;   InChIKey=DNTGGZPQPQTDQF-UHFFFAOYSA-N;   N-ethyl-o-crotonotoluidide;   SMILES=CCN(C(=O)C=CC)c1ccccc1C;   crotalgin;   crotamitone;   crotamitonum;   crotonyl-N-ethyl-o-toluidine
 xref: Beilstein:3275497;   CAS:483-63-6;   DrugBank:DB00265;   Drug_Central:744;   KEGG:D01381;   LINCS:LSM-3274
 xref_mesh: MESH:C005553
 xref: Patent:GB615137


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crotamiton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO crotamiton results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        pesticide 17927
          acaricide 13713
            scabicide 5598
              crotamiton 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              alpha,beta-unsaturated carboxylic acid amide 7106
                                                enamide 7106
                                                  crotamiton 1
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