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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:geranyl diphosphate
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Accession:CHEBI:17211 term browser browse the term
Definition:The diphosphate of the polyprenol compound geraniol.
Synonyms:related_synonym: (2E)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate;   Formula=C10H20O7P2;   InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+;   InChIKey=GVVPGTZRZFNKDS-JXMROGBWSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\COP(O)(=O)OP(O)(O)=O;   geranyl pyrophosphate
 alt_id: CHEBI:14299;   CHEBI:24223;   CHEBI:42877;   CHEBI:5332
 xref: Beilstein:1915690;   CAS:763-10-0;   DrugBank:DB02552;   KEGG:C00341;   KNApSAcK:C00000846;   LIPID_MAPS_instance:LMPR0102010001
 xref_mesh: MESH:C015234
 xref: PDBeChem:GPP;   PMID:19049370;   PMID:19856009;   PMID:23607888;   PMID:7753173;   Reaxys:1915690
 cyclic_relationship: is_conjugate_acid_of CHEBI:58057


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geranyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases abundance		 ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate] CTD PMID:19819230 PMID:19856009 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions		 ISO geranyl diphosphate results in decreased activity of MVK protein
geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form CTD PMID:19819230 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        fragrance 1000
          geraniol 398
            geranyl diphosphate 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      chalcogen 19545
                        oxygen atom 19520
                          oxygen molecular entity 19520
                            hydroxides 19332
                              oxoacid 18768
                                pnictogen oxoacid 13221
                                  phosphorus oxoacid 12425
                                    phosphoric acids 11425
                                      phosphoric acid 11425
                                        phosphoric acid derivative 11234
                                          phosphate 11233
                                            organic phosphate 11233
                                              phospholipid 316
                                                isoprenoid phosphate 75
                                                  prenol phosphate 75
                                                    polyprenol phosphate 66
                                                      polyprenyl diphosphate 66
                                                        geranyl diphosphate 3
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