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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:paralytic shellfish toxin
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Accession:CHEBI:167564 term browser browse the term
Definition:An alkaloid compound that is 2,6-diamino-4-methyl-pyrollo[1,2-c]-purin-10-diol produced by several cyanobacteria and dinoflagellates, which can result in paralytic shellfish poisoning when ingested.
Synonyms:related_synonym: Formula=C9H12N6O2R4;   PSP toxin;   SMILES=[C@@H]1([C@]2([C@@]3(N(C(N1*)=N)CC(C3(O)O)(*)*)NC(N2)=N)[H])C*;   saxitoxins
 xref: PMID:11319121;   PMID:20692275;   PMID:25871287;   PMID:30605564;   PMID:30983320;   PMID:32456077


show annotations for term's descendants           Sort by:
neosaxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions ISO neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:32471037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
saxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity		 ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein		 CTD PMID:29128272 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Alb albumin decreases expression ISO Saxitoxin results in decreased expression of ALB protein CTD PMID:29228856 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like decreases expression ISO Saxitoxin results in decreased expression of ARPC5L protein CTD PMID:29228856 NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538 		JBrowse link
G Cfl2 cofilin 2 affects expression ISO Saxitoxin affects the expression of CFL2 protein CTD PMID:29228856 NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674 		JBrowse link
G Eno1 enolase 1 affects expression ISO Saxitoxin affects the expression of ENO1 protein CTD PMID:29228856 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Saxitoxin results in decreased expression of HNRNPL protein CTD PMID:29228856 NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Saxitoxin results in decreased expression of VDAC1 protein CTD PMID:29228856 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression ISO Saxitoxin results in increased expression of YWHAB protein CTD PMID:29228856 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        poison 18590
          toxin 15966
            paralytic shellfish toxin 9
              Decarbamoylgonyautoxin 1 0
              Decarbamoylgonyautoxin III 0
              Gonyautoxin 1 0
              Gonyautoxin 2 0
              Gonyautoxin 5 0
              decarbamoylsaxitoxin 0
              neosaxitoxin 1
              saxitoxin + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterotricyclic compound 15623
                                      pyrrolopurine 9
                                        paralytic shellfish toxin 9
                                          Decarbamoylgonyautoxin 1 0
                                          Decarbamoylgonyautoxin III 0
                                          Gonyautoxin 1 0
                                          Gonyautoxin 2 0
                                          Gonyautoxin 5 0
                                          decarbamoylsaxitoxin 0
                                          neosaxitoxin 1
                                          saxitoxin + 9
paths to the root