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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-oxoproline
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Accession:CHEBI:16010 term browser browse the term
Definition:An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.
Synonyms:exact_synonym: 5-oxopyrrolidine-2-carboxylic acid
 related_synonym: 5-Pyrrolidone-2-carboxylic acid;   5-oxo-DL-proline;   Formula=C5H7NO3;   Glp;   InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9);   InChIKey=ODHCTXKNWHHXJC-UHFFFAOYSA-N;   Pyroglutamate;   Pyroglutamic acid;   SMILES=OC(=O)C1CCC(=O)N1
 alt_id: CHEBI:12157;   CHEBI:20624;   CHEBI:2116;   CHEBI:44943
 xref: Beilstein:82131;   CAS:149-87-1;   PMID:17439666;   PMID:22770225;   PMID:23217740;   Reaxys:82131;   Wikipedia:Pyroglutamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:57606


show annotations for term's descendants           Sort by:
5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            eukaryotic metabolite 19337
              animal metabolite 19202
                mammalian metabolite 19201
                  human metabolite 18722
                    5-oxoproline 2
                      5-oxo-D-proline 0
                      5-oxo-L-proline + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              lactam 8390
                                                gamma-lactam 6647
                                                  pyrrolidin-2-ones 164
                                                    5-oxoproline 2
                                                      5-oxo-D-proline 0
                                                      5-oxo-L-proline + 2
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