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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-methyltetrahydrofolic acid
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Accession:CHEBI:15641 term browser browse the term
Definition:A tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5.
Synonyms:exact_synonym: N-(4-{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
 related_synonym: 5-Methyltetrahydrofolate;   5-methyl-5,6,7,8-tetrahydrofolate;   5-methyl-5,6,7,8-tetrahydrofolic acid;   5-methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid;   5-methyl-THF;   5-methyltetrahydropteroylglutamic acid;   Formula=C20H25N7O6;   InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1;   InChIKey=ZNOVTXRBGFNYRX-ABLWVSNPSA-N;   N(5)-methyl-tetrahydrofolate;   N(5)-methyl-tetrahydrofolic acid;   N(5)-methyltetrahydrofolic acid;   N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   N-methyltetrahydrofolate;   N-methyltetrahydrofolic acid;   SMILES=CN1C(CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2
 alt_id: CHEBI:12146;   CHEBI:182992;   CHEBI:2097
 xref: AGR:IND606335060;   CAS:134-35-0;   Chemspider:8001181;   DrugBank:DB04789;   FooDB:FDB022600;   HMDB:HMDB0001396;   KEGG:C00440;   KNApSAcK:C00007252
 xref_mesh: MESH:C005984
 xref: PMID:10993519;   PMID:11816560;   PMID:15094208;   PMID:15173401;   PMID:15717023;   PMID:16310391;   PMID:16429378;   PMID:1683972;   PMID:17176169;   PMID:18160726;   PMID:1969014;   PMID:2445472;   PMID:32170863;   PMID:34311437;   PMID:34886014;   PMID:6609768;   PMID:8031869;   PMID:8613033;   PMID:9101216;   PMID:9870205
 cyclic_relationship: is_conjugate_acid_of CHEBI:189667


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5-methyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 decreases abundance ISO ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate CTD PMID:16627483 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Folr1 folate receptor alpha increases uptake ISO FOLR1 protein results in increased uptake of 5-methyltetrahydrofolate CTD PMID:17473184 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Gnmt glycine N-methyltransferase affects binding EXP GNMT protein binds to 5-methyltetrahydrofolate CTD PMID:17158459 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases chemical synthesis ISO MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate CTD PMID:7647779 PMID:9719624 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding ISO 5-methyltetrahydrofolate binds to MTR protein CTD PMID:17477549 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of 5-methyltetrahydrofolate CTD PMID:17369066 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Docosahexaenoic Acids co-treated with 5-methyltetrahydrofolate] results in increased expression of PCNA protein CTD PMID:16870008 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 ISO
EXP		 [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid
5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]		 CTD PMID:14612385 PMID:17034785 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity		 ISO 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
5-methyltetrahydrofolate results in decreased activity of SLC46A1 protein		 CTD PMID:17475902 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO 5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]; dorsomorphin inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] CTD PMID:26400185 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            eukaryotic metabolite 19307
              fungal metabolite 17857
                Saccharomyces cerevisiae metabolite 17290
                  5,6,7,8-tetrahydrofolic acid 14
                    5-methyltetrahydrofolic acid 10
                      (6S)-5-methyltetrahydrofolic acid 0
                      5-methyltetrahydrofolyl polyglutamate macromolecule + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        amino acid 15928
                                          alpha-amino acid 13848
                                            L-alpha-amino acid 12839
                                              glutamine family amino acid 10313
                                                L-glutamic acid 10251
                                                  L-glutamic acid derivative 9398
                                                    folic acids 9398
                                                      tetrahydrofolic acid 68
                                                        5,6,7,8-tetrahydrofolic acid 14
                                                          5-methyltetrahydrofolic acid 10
                                                            (6S)-5-methyltetrahydrofolic acid 0
                                                            5-methyltetrahydrofolyl polyglutamate macromolecule + 0
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