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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-hydroxymidazolam beta-D-glucuronide
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Accession:CHEBI:145334 term browser browse the term
Definition:A beta-D-glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen has been replaced by a 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl group. It is the glucuronidated conjugate of the midazolam metabolite, 1-hydroxymidazolam.
Synonyms:exact_synonym: [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methyl beta-D-glucopyranosiduronic acid
 related_synonym: 1'-OH MDZ glucuronide;   1-hydroxymethylmidazolam glucuronide;   1-hydroxymidazolam glucuronide;   Formula=C24H21ClFN3O7;   InChI=1S/C24H21ClFN3O7/c25-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)26)28-9-12-8-27-17(29(12)16)10-35-24-21(32)19(30)20(31)22(36-24)23(33)34/h1-8,19-22,24,30-32H,9-10H2,(H,33,34)/t19-,20-,21+,22-,24+/m0/s1;   InChIKey=ICIUMXQTLQXWGL-QMDPOKHVSA-N;   MDZ-glucuronide;   SMILES=C1(=NCC=2N(C=3C1=CC(=CC3)Cl)C(=NC2)CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(O)=O)O)O)O)C=5C=CC=CC5F
 xref: CAS:81256-81-7
 xref_mesh: MESH:C061795
 xref: PMCID:PMC2934138;   PMID:10519446;   PMID:14513773;   PMID:1767626;   PMID:17998299;   PMID:18256203;   PMID:18537963;   PMID:20713656;   PMID:22660604;   PMID:2582710;   PMID:6691561


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1-hydroxymidazolam beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide CTD PMID:27485346 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          apoptosis inducer 13624
            midazolam 29
              1-hydroxymidazolam 3
                1-hydroxymidazolam beta-D-glucuronide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      carbohydrate derivative 14278
                                        glycosyl compound 13035
                                          glycoside 11818
                                            glycosiduronic acid 192
                                              glucosiduronic acid 192
                                                beta-D-glucosiduronic acid 47
                                                  1-hydroxymidazolam beta-D-glucuronide 1
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