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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fotemustine
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Accession:CHEBI:131848 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Synonyms:related_synonym: (+-)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate;   Formula=C9H19ClN3O5P;   Muphoran;   Mustoforan;   S 10036;   Servier-10036;   diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate;   fotemustina;   fotemustinum;   rac-fotemustine
 alt_id: MESH:C054368
 xref: CAS:92118-27-9;   KEGG:D07255
 xref_mesh: MESH:C054368
 xref: PMID:15020614;   PMID:23560594;   PMID:24023343;   PMID:24800248;   PMID:25538176;   PMID:25702193;   PMID:2627116;   PMID:26458240;   PMID:26542177;   PMID:26750128;   PMID:26951379;   PMID:27057436;   Patent:FR2536075;   Patent:US4567169;   Reaxys:8626774;   Wikipedia:Fotemustine


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fotemustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO fotemustine results in increased expression of CDKN1A mRNA CTD PMID:25125662 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO fotemustine results in increased expression of FAS mRNA CTD PMID:25125662 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of FOS mRNA; fotemustine results in increased expression of FOS protein		 CTD PMID:23578789 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO fotemustine results in increased expression of GADD45A mRNA CTD PMID:25125662 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO fotemustine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of JUN mRNA; fotemustine results in increased expression of JUN protein		 CTD PMID:23578789 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to fotemustine CTD PMID:12970393 PMID:16039682 PMID:20556481 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Polh DNA polymerase eta multiple interactions
increases expression
decreases response to substance		 ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]
fotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH protein
POLH protein results in decreased susceptibility to fotemustine		 CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO fotemustine promotes the reaction [TP53 protein binds to POLH promoter]
fotemustine results in increased expression of TP53 protein; fotemustine results in increased expression of TP53 protein modified form		 CTD PMID:25125662 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trex1 three prime repair exonuclease 1 multiple interactions
increases expression
affects response to substance		 ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]; fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of TREX1 mRNA; fotemustine results in increased expression of TREX1 protein
TREX1 affects the susceptibility to fotemustine		 CTD PMID:23578789 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      chemical substance 14383
        mixture 13700
          racemate 12076
            fotemustine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                urea 5571
                                                  ureas 5569
                                                    N-nitrosoureas 2115
                                                      diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 11
                                                        (R)-fotemustine 11
                                                          fotemustine 11
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