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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydroouabain
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Accession:CHEBI:131146 term browser browse the term
Definition:A cardenolide glycoside that is ouabain in which the double bond in the lactone ring has been reduced to a single bond. It is a cardiac glycoside and a derivative of ouabain which is used as a sodium pump antagonist and exhibits ionotropic effects.
Synonyms:related_synonym: (1beta,3beta,5beta,11alpha,20xi)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycardanolide;   3beta-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-1beta,5,11alpha,14,19-pentahydroxy-5beta,20xi-cardanolide;   Formula=C29H46O12;   InChI=1S/C29H46O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h13-19,21-25,30-32,34-38H,3-12H2,1-2H3/t13-,14?,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1;   InChIKey=ZTFGOPUOTATSAL-CFVDWFIMSA-N;   SMILES=[H][C@@]1(CC[C@]2(O)[C@]3([H])CC[C@]4(O)C[C@H](C[C@@H](O)[C@]4(CO)[C@@]3([H])[C@H](O)C[C@]12C)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C1COC(=O)C1;   dihydro-g-strophanthin
 xref: CAS:1183-35-3;   HMDB:HMDB0251322;   LINCS:LSM-42697
 xref_mesh: MESH:C000977
 xref: PMID:10564763;   PMID:1178065;   PMID:1192564;   PMID:1239002;   PMID:12399817;   PMID:12954807;   PMID:1311424;   PMID:19778013;   PMID:2442703;   PMID:2541941;   PMID:2851817;   PMID:29981919;   PMID:32311597;   PMID:6290892;   PMID:6326779;   PMID:6571229;   PMID:677969;   PMID:7498266;   PMID:7854342;   PMID:8387052;   PMID:8411196;   PMID:978481;   Reaxys:71786


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dihydroouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression		 ISO dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
dihydroouabain results in increased expression of G6PC1 mRNA		 CTD PMID:29981919 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO dihydroouabain results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO dihydroouabain results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions		 ISO dihydroouabain results in increased expression of NPAS2 mRNA
dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]		 CTD PMID:29981919 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
increases expression		 ISO dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA] CTD PMID:29981919 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            radiosensitizing agent 1854
              dihydroouabain 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      carbohydrate derivative 14278
                                        glycosyl compound 13035
                                          glycoside 11818
                                            deoxy hexoside 7709
                                              rhamnoside 451
                                                alpha-L-rhamnoside 451
                                                  ouabain 202
                                                    dihydroouabain 5
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