Seven Stat transcription factors positively and negatively regulate the expression of a vast array of genes whose identification is still far from being complete. The combination of Stats and the tissue in which they act at a particular point of time will dictate the subset of genes they control, further contributing to the challenge of target identification. Constitutive phosphorylation of Stat1, Stat3 and Stat5 has been observed in several cancer lines and activating mutations for the Jak kinases of Stats have been reported.  For more information on Stats, cancer and immunity with selected targets for individual Stats and emphasis on Stat3 and Nf-kappaB up- and down-regulated genes, check PMID 19851315; also check PMIDs 15539936  and 16947086 for more information on Stat3, Stat5, their roles, targets and disease involvement, in particular cancer. Some of the target genes are listed with aliases in parentheses, full names and links to gene report pages:

Vegfa (Vegf, vegf-a) – vascular endothelial growth factor A
Bcl2 (Bcl-2) – BCL2, apoptosis regulator
Bcl2l1 (Blc-xL) – Bcl2-like 1
Mcl1 (Mcl-1) – MCL1, BCL2 family apoptosis regulator
Ccnd1 (Prad1) – cyclin D1
Ccnd2 – cyclin D2
Ccnd3 (D3-type cyclin) – cyclin D3
Mmp2 (gelatinase A, Mmp-2) – matrix metallopeptidase 2
Mmp9 (GELB, Mmp-9) – matrix metallopeptidase 9
Myc (c-Myc, myelocytomatosis oncogene) – MYC proto-oncogene, bHLH transcription factor
Birc5 (survivin) – baculovirus IAP repeat-containing 5
CD40 (Cd40 antigen) – CD40 molecule
CD80 – Cd80 molecule
Gata3 – GATA binding protein 3
Cdkn1a (p21, Cap20, Cip1) – cyclin-dependent kinase inhibitor 1A
Socs1 – suppressor of cytokine signaling 1
Socs3 – suppressor of cytokine signaling 3