Gnai proteins in ACh signaling

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Gnai proteins in ACh signaling

The heterotrimeric G proteins are subdivided into four families depending on the type of G alpha subunit to which the G protein-coupled receptors (GPCRs) couple. The M2 type muscarinic receptor couples to Galphai family members 1 and 2. The two proteins are listed with aliases in parentheses, full names and links to gene report pages:

Gnai1 (BPGTPB) – G protein subunit alpha i1
Gnai2 (GIP, alpha inhibiting 2) – G protein subunit alpha i2

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.