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Pathways

Ar chaperones

The Ar chaperones keep the receptor in a partially unfolded but ligand-primed state. The complex is known as the folodosome and its assembly is thought to proceed in an assembly-line fashion – see PMIDs 1635682617163421. Several chaperones are listed with aliases in parentheses, full names and links to gene report pages:

Hspa8 (Hsc70) – heat shock protein family A (Hsp70) member 8
St13 (Hip, p48) – ST13, Hsp70 interacting protein
Stip1 (Hop, p60) – stress-induced phosphoprotein 1
Hsp90aa1 (Hsp 90-alpha, Hsp86) – heat shock protein 90 alpha family class A member 1
Hsp90ab1 (Hsp 90-beta, Hsp84) – heat shock protein 90 alpha family class B member 1
Dnaja2 (Dj3, Dnj3, Cpr3, Hirip4) – DnaJ heat shock protein family (Hsp40) member A2


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.