Immune and Inflammatory Disease Portal -Rat Strain Models
These were immunized with guinea-pig spinal cord to produce 100 per cent incidence of EAE (REF RGD ID: 704436)
These are resistant to EAE (REF RGD ID: 704436)
These are resistant to type II collagen induced arthritis (REF RGD ID 1285224)
These are resistant to experimentally induced arthritis by collagen.(REF RGD ID 61067)
These are susceptible to experimentally induced arthritis by collagen and experimentally induced autoimmune thyroid diseases, but resistant to spontaneous insulin-dependent diabetes and spontaneous autoimmune thyroid diseases.(REF RGD ID 61067)
These are resistant to Pristane-induced arthritis (REF RGD ID 631850).
Progressive, symmetric inflammation which characterizes arthritis can be induced in rats by multiple triggering stimuli that regulate disease expression (for example MHC and non-MHC genetic loci). DA rats are susceptible to arthritis which is induced with homologous or heterologous type II collagen in incomplete Freund’s adjuvant (IFA) (REF RGD ID 631168), Mbt-AIA, avridine-induced arthritis (REF RGD ID 631168)., Pristane-induced arthritis (REF RGD ID 631850) and Oil-induced arthritis (REF RGD ID 631168).
These rats are resistant to type II collagen in incomplete Freund’s adjuvant (IFA) (REF RGD ID 631168), Mbt-AIA, avridine-induced arthritis (REF RGD ID 631168)., Pristane-induced arthritis (REF RGD ID 631850) and Oil-induced arthritis (REF RGD ID 631168).
Susceptible to Multiple Sclerosis. Perivenous inflammation restricted to CNS associated with primary demyelination resulting in large confluent demyelinated plaques; higher serum levels of anti-MOG IgG, IgG2a, IgG2b, IgG2c than ACI/SegHsd (REF RGD ID: 69712). Develops paralysis with two to three relapses (REF RGD ID: 61031). Hemiparalysis, relapsing/remitting disease in ~70% in MOG induced disease (REF RGD ID: 1302437)
Susceptible to Multiple Sclerosis. High demyelination and inflammation indices with MOG induction, acute lethal 25%; monophasic 19%; relapsing/remitting 33%; primary progressive 6.3%, impaired balance 8.3% (REF RGD ID: 629629)
Resistant to Multiple Sclerosis. 1/21 showed demyelination with 50µg rMOG(aa 1-125) and spinal cord lesions (REF RGD ID: 69712).
Resistant to Multiple Sclerosis. 0/15 incident rate with spinal cord homogenate (REF RGD ID: 61031).
Resistant to active induction of EAE but susceptible to transferred EAE when injected with encephalitogenic T cells (REF RGD ID: 724738)
Resistant to Multiple Sclerosis. 4/61 incident rate with 20µg rMOG(aa 1-125)(REF RGD ID: 629629)
