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Strain Registration

Strain: F344-Lgi1m1Kyo

Symbol: F344-Lgi1m1Kyo
Strain: F344-Lgi1m1Kyo
Substrain: Kyo
RGD ID: 8552275
Citation ID: RRID:RGD_8552275
Ontology ID: RS:0003717
Alleles: Lgi1m1Kyo;   Lgi1
Variant(s): Lgi1m1Kyo-var1
Also Known As: F344-Lgi1m1Kyo; Lgi1 mutant rat; NBRP Rat No: 0656; F344-Lgi1^[m1Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: The University of Tokyo, The Institute of Medical Science
Description: Developed by gene driven ENU mutagenesis in F344/NSlc rats. Lgi1-mutant rats carrying a missense mutation (c.1154 T > G)(L385R).
Coat Color: albino
Inbred Generations: N10
Last Known Status: Cryopreserved Sperm (as of 2017-03-17)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81245,455,691 - 245,497,036RGD_MAPPER_PIPELINE
mRatBN7.21236,083,750 - 236,083,750RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01256,996,315 - 256,996,315RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.01264,436,441 - 264,477,332RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.41242,593,236 - 242,634,141RGD_MAPPER_PIPELINERGSC_v3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A rat model for LGI1-related epilepsies. Baulac S, etal., Hum Mol Genet. 2012 Aug 15;21(16):3546-57. doi: 10.1093/hmg/dds184. Epub 2012 May 15.
2. Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. Kinboshi M, etal., Int J Mol Sci. 2019 Feb 26;20(5). pii: ijms20051013. doi: 10.3390/ijms20051013.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Lgi1m1Kyo-var1 chr1 236083750 236083750 T G point_mutation mRatBN7.2
Lgi1m1Kyo-var1 chr1 256996315 256996315 T G point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_reproduction Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-17 F344-Lgi1m1Kyo    F344-Lgi1m1Kyo    Symbol updated 68687 APPROVED
2017-03-17 F344-Lgi1m1Kyo    F344-Lgi1m1Kyo    Symbol updated 68687 APPROVED
2014-04-23 F344-Lgi1m1Kyo    F344-Lgi1m1Kyo    Name updated 68913 APPROVED
2014-04-23 F344-Lgi1m1Kyo    F344-Lgi1m1Kyo    Name updated 68913 APPROVED