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Strain Registration

Strain: RCS-p+/LavRrrc

Symbol: RCS-p+/LavRrrc
Strain: RCS-p+
Substrain: LavRrrc
RGD ID: 1358259
Citation ID: RRID:RRRC_00315
Ontology ID: RS:0000655
Also Known As: RCS-p+; RCS-p+/LavRrrc; rdy-, p+; RCS-p+/+/LavRrrc; RCS-p+/LavRrrc; RCS-p^[+]/LavRrrc
Type: congenic
Available Source: Retinal Degeneration Rat Model Resource , Rat Resource and Research Center
Origination: Retinal Degeneration Rat Model Resource , Rat Resource and Research Center
Description: This strain has homozygous wild type at the pink eye (p+) locus and homozygous for a deletion in the Mertk gene. Developed by intercrossing (brother x sister) two black-eyed p/+ rats from the RCS-p/+ strain. The black-eyed animals were tested for homozygous p locus and then backcrossed to the parental strain.
Genetic Markers: Pink-eyed-dilute
Coat Color: Hooded
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-30)

Congenic Strains
(LE x RCS-p+/LavRrrc)F1




References

References - curated
# Reference Title Reference Citation
1. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. LaVail MM and Battelle BA, Exp Eye Res 1975 Aug;21(2):167-92.
2. Photoreceptor characteristics in congenic strains of RCS rats. LaVail MM Invest Ophthalmol Vis Sci 1981 May;20(5):671-5.
3. Congenic strains of RCS rats with inherited retinal dystrophy. LaVail MM, etal., J Hered 1975 Jul-Aug;66(4):242-4.
4. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These are black hooded, black eyed, dystrophic and are heterozygous at the pink-eyed dilution locus. They have a slower rate of degeneration than the pink-eyed rat and a significant hemispheric difference in the rate of degeneration in the peripheral retina. 632095
strain_characteristics These are black hooded, black eyed, dystrophic and are heterozygous at the pink-eyed dilution locus. They have a slower rate of degeneration than the pink-eyed rat and a significant hemispheric difference in the rate of degeneration in the peripheral retina. 1358250
strain_life_disease The eye pigmentation in these rats slows the pace of disease to the same extent as dark-rearing RCS rats. 1358250

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-23 RCS-p+/LavRrrc    RCS-p+/+/LavRrrc    Symbol and/or name change 68913 APPROVED
2020-04-23 RCS-p+/+/LavRrrc    RCS-p+/LavRrrc    Symbol and/or name change 68913 APPROVED
2015-10-01 RCS-p+/LavRrrc    RCS-p+/LavRrrc    Name updated 68913 APPROVED
2015-10-01 RCS-p+/LavRrrc    RCS-p+/LavRrrc    Name updated 68913 APPROVED
2012-08-23 RCS-p+/LavRrrc    RCS-p+/Lav    Symbol updated 68687 APPROVED
2012-08-23 RCS-p+/LavRrrc    RCS-p+/Lav    Name updated 68913 APPROVED
2012-08-23 RCS-p+/LavRrrc    RCS-p+/Lav    Name updated 68913 APPROVED
2012-08-23 RCS-p+/LavRrrc    RCS-p+/Lav    Symbol updated 68687 APPROVED
2012-04-18 RCS-p+/Lav    RCS-p+/Lav    Name updated 68913 APPROVED
2012-04-18 RCS-p+/Lav    RCS-p+/Lav    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00315 RGD