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Strain Registration

Strain: (LE x RCS-p+/LavRrrc)F1

Symbol: (LE x RCS-p+/LavRrrc)F1
Strain: (LE x RCS-p+/LavRrrc)F1
Substrain: LavRRRC
RGD ID: 7364938
Citation ID: RRID:RRRC_00662
Ontology ID: RS:0003536
Alleles: Mertk
Also Known As: (LE x RCS-p+/LavRrrc)F1; LE;RCS-p+ /LavRrrc; (LE x RCS-p^[+]/LavRrrc)F1
Type: congenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: RCS-p+/LavRrrc males were mated to LE females.
Coat Color: black hooded
Last Known Status: Cryopreserved Sperm (as of 2019-02-18)
Research Usage Retinal Research






References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics homozygous for wild type allele at pink eye (p) locus and homozygous for the Mertk mutant allele 2292495
strain_other Pigmented strain that exhibits retinal (photoreceptor) degeneration due to a mutation in the Mertk gene. The gene is expressed in the retinal pigment epithlium. The mutation leads to the prevention of phagocytosis of rod outer segments, with subsequent photoreceptor cell death. The rate of degeneration and loss of photoreceptor cells in the pigmented dystrophic retinas is slowed by about 7-10 days in the central/posterior retina and significantly more in the peripheral retinal in the superior hemisphere when compared to pink-eyed rats carrying the Mertk mutation. 2292495
strain_reproduction Intra-strain matings can be used to generate animals with pigmented eyes that are homozygous for the Mertk mutation. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-11 (LE x RCS-p+/LavRrrc)F1    (LE x RCS-p+/LavRrrc)F1    Name updated 68913 APPROVED
2013-10-11 (LE x RCS-p+/LavRrrc)F1    (LE x RCS-p+/LavRrrc)F1    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00662 RGD