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Strain Registration

Strain: SD-Tg(CD59-HBA1)Bryd

Symbol: SD-Tg(CD59-HBA1)Bryd
Strain: SD-Tg(CD59-HBA1)
Substrain: Bryd
RGD ID: 11084925
Citation ID: RRID:RRRC_00754
Ontology ID: RS:0004189
Alleles: CD59
Also Known As: RRRC:00754; SD-Tg(CD59-HBA1)Bryd; SD-Tg(CD59-HBA1)BrydRrrc
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: Transgene: human CD59 gene (cDNA) under control of alpha-globin regulatory elements (alpha-globin promoter and alpha hemoglobin locus control region). Upon administration of intermedilysin (ILY), cells expressing human CD59 will be selectively ablated
Genetic Status: Hemizygous
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Research Usage intravascular hemolysis and related sequelae of anemia, hemoglobinemia, and hemoglobinuria






References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Transgene positive rats will develop intravascular hemolysis and anemia following administration of intermedilysin (ILY) due to specific ablation of human-CD59 expressing red blood cells. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-07 SD-Tg(CD59-HBA1)Bryd    SD-Tg(CD59-HBA1)BrydRrrc    Symbol and/or name change 68913 APPROVED
2022-07-07 SD-Tg(CD59-HBA1)BrydRrrc    SD-Tg(CD59-HBA1)Bryd    Symbol and/or name change 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00754 RGD