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Strain Registration

Strain: SD-Tg(Gfap-Tk1)Jog

Symbol: SD-Tg(Gfap-Tk1)Jog
Strain: SD-Tg(Gfap-Tk1)
Substrain: Jog
Full Name: SD-Tg(Gfap-Tk1)
RGD ID: 11040941
Citation ID: RRID:RGD_11040941
Ontology ID: RS:0004132
Alleles: Tk1;   Gfap
Also Known As: GFAP-TK; NBRP Rat No: 0639; SD-Tg(Gfap-Tk)Jog
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Description: The rats were originally generated by the University of Michigan Transgenic Animal Model Core, University of Michigan. They used a Crl:CD(SD) sub strain of Sprague-Dawley rats, obtained from Charles River Laboratory (Wilmington, MA, USA). The F1 rats have been bred in the UK with Hsd:Sprague Dawley (Harlan laboratories, UK), which are direct descendants of the original 1925 SD-company colony (Madison, Wisconsin, USA). The GFAP-TK rat was generated by pronuclear injection of a Gfap-Tk Bacterial Artificial Chromosome (BAC) construct, engineered using RedET-mediated homologous recombination methods.
Coat Color: White
Inbred Generations: F10
Last Known Status: Cryopreserved Embryo (as of 2023-12-14)






References

References - curated
# Reference Title Reference Citation
1. Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model. Groves JO, etal., PLoS Genet. 2013;9(9):e1003718. doi: 10.1371/journal.pgen.1003718. Epub 2013 Sep 5.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Rats show no phenotype until dosed with the antiviral agant ganciclovir. Chronic dosing at 10mg/kg/day via subcutaneous minipump for 21 days results in a loss of DCX-positive cells in the dentate gyrus and subventricular zone. 1302502
strain_reproduction Males are infertile. Females generate good litters of 10-15 pups showing 50% heterozygous offspring 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 SD-Tg(Gfap-Tk1)Jog    SD-Tg(Gfap-Tk)Jog    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED