Wls (Wnt ligand secretion mediator) - Rat Genome Database

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Gene: Wls (Wnt ligand secretion mediator) Rattus norvegicus
Analyze
Symbol: Wls
Name: Wnt ligand secretion mediator
RGD ID: 735139
Description: Enables mu-type opioid receptor binding activity. Involved in positive regulation of dendrite morphogenesis. Located in dendrite cytoplasm; dendrite membrane; and nucleus. Is active in postsynapse. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CG6210-like; evenness interrupted homolog; EVI; G protein-coupled receptor 177; Gpr177; integral membrane protein GPR177; LOC108350151; LOC362065; uncharacterized LOC108350151; wntless homolog; wntless homolog (Drosophila); wntless Wnt ligand secretion mediator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82251,590,653 - 251,705,991 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2251,590,614 - 251,706,380 (+)EnsemblGRCr8
mRatBN7.22248,931,885 - 249,047,248 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2248,931,903 - 249,048,298 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2256,651,639 - 256,774,797 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02254,545,165 - 254,668,321 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02249,504,626 - 249,627,778 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2251,506,310 - 251,629,486 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2251,628,130 - 251,751,280 (+)NCBILyon_Normotensive
Lyon_Hypertensive2251,226,136 - 251,349,298 (+)NCBILyon_Hypertensive
F344_StmMcwi2177,577,684 - 177,700,862 (+)NCBIF344_StmMcwi
Rnor_6.02266,315,036 - 266,431,220 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2266,315,036 - 266,432,558 (+)Ensemblrn6Rnor6.0
Rnor_5.02284,950,842 - 285,064,166 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42258,014,437 - 258,128,180 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2240,667,931 - 240,781,679 (+)NCBICelera
RGSC_v3.12258,029,043 - 258,141,986 (+)NCBI
Cytogenetic Map2q45NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
Tetrachlorobisphenol A  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Bartscherer K, etal., Cell. 2006 May 5;125(3):523-33.
2. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
3. Wntless in Wnt secretion: molecular, cellular and genetic aspects. Das S, etal., Front Biol (Beijing). 2012 Dec 1;7(6):587-593.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Jaremko KM, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:53-65. doi: 10.1016/j.pnpbp.2013.12.003. Epub 2013 Dec 12.
6. Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. Jin J, etal., BMC Neurosci. 2010 Mar 9;11:33. doi: 10.1186/1471-2202-11-33.
7. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Reyes BA, etal., Exp Neurol. 2012 Jan;233(1):205-13. doi: 10.1016/j.expneurol.2011.09.037. Epub 2011 Oct 6.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15326124   PMID:15489334   PMID:16678095   PMID:17804805   PMID:18160348   PMID:19841259   PMID:20614471   PMID:20652957   PMID:24768165   PMID:26501177  


Genomics

Comparative Map Data
Wls
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82251,590,653 - 251,705,991 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2251,590,614 - 251,706,380 (+)EnsemblGRCr8
mRatBN7.22248,931,885 - 249,047,248 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2248,931,903 - 249,048,298 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2256,651,639 - 256,774,797 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02254,545,165 - 254,668,321 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02249,504,626 - 249,627,778 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2251,506,310 - 251,629,486 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2251,628,130 - 251,751,280 (+)NCBILyon_Normotensive
Lyon_Hypertensive2251,226,136 - 251,349,298 (+)NCBILyon_Hypertensive
F344_StmMcwi2177,577,684 - 177,700,862 (+)NCBIF344_StmMcwi
Rnor_6.02266,315,036 - 266,431,220 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2266,315,036 - 266,432,558 (+)Ensemblrn6Rnor6.0
Rnor_5.02284,950,842 - 285,064,166 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42258,014,437 - 258,128,180 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2240,667,931 - 240,781,679 (+)NCBICelera
RGSC_v3.12258,029,043 - 258,141,986 (+)NCBI
Cytogenetic Map2q45NCBI
WLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,098,459 - 68,232,546 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,098,473 - 68,233,120 (-)Ensemblhg38GRCh38
GRCh37168,564,142 - 68,698,229 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,336,739 - 68,470,841 (-)NCBIBuild 36Build 36hg18NCBI36
Celera166,854,843 - 66,988,904 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef166,674,244 - 66,808,306 (-)NCBIHuRef
CHM1_1168,679,493 - 68,813,680 (-)NCBICHM1_1
T2T-CHM13v2.0167,975,934 - 68,110,470 (-)NCBIT2T-CHM13v2.0
Wls
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393159,545,287 - 159,644,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3159,545,309 - 159,644,300 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383159,839,650 - 159,938,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3159,839,672 - 159,938,664 (+)Ensemblmm10GRCm38
MGSCv373159,502,659 - 159,598,042 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363159,775,030 - 159,871,126 (+)NCBIMGSCv36mm8
Celera3166,277,256 - 166,372,735 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map382.65NCBI
Wls
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,374,401 - 23,466,475 (+)Ensembl
ChiLan1.0NW_00495542323,374,401 - 23,465,308 (+)NCBIChiLan1.0ChiLan1.0
WLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21158,639,149 - 158,773,214 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11157,798,726 - 157,958,728 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,336,009 - 67,470,265 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,291,878 - 69,425,652 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,318,742 - 69,425,652 (-)EnsemblpanPan2panpan1.1
WLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,053,242 - 77,146,549 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,053,237 - 77,317,761 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha679,664,500 - 79,757,209 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0677,650,853 - 77,743,886 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,650,543 - 77,764,760 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,209,157 - 77,301,736 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0677,102,941 - 77,195,585 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,592,036 - 77,684,885 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,849,811 - 80,951,545 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365913,537,981 - 3,639,774 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365913,537,981 - 3,639,774 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,399,926 - 144,555,880 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16144,242,639 - 144,529,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26133,711,371 - 133,819,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12064,879,594 - 64,987,460 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2064,879,864 - 64,977,038 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603352,598,873 - 52,734,627 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wls
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,481,427 - 27,570,439 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474227,481,480 - 27,570,439 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wls
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v132,283,674 - 2,380,963 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:301
Count of miRNA genes:183
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000055245
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat

Markers in Region
RH140979  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22249,043,273 - 249,043,463 (+)MAPPERmRatBN7.2
Rnor_6.02266,427,246 - 266,427,435NCBIRnor6.0
Rnor_5.02285,060,192 - 285,060,381UniSTSRnor5.0
RGSC_v3.42258,128,322 - 258,128,511UniSTSRGSC3.4
Celera2240,777,705 - 240,777,894UniSTS
Cytogenetic Map2q45UniSTS
RH127338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22249,042,476 - 249,042,657 (+)MAPPERmRatBN7.2
Rnor_6.02266,426,449 - 266,426,629NCBIRnor6.0
Rnor_5.02285,059,395 - 285,059,575UniSTSRnor5.0
RGSC_v3.42258,127,525 - 258,127,705UniSTSRGSC3.4
Celera2240,776,908 - 240,777,088UniSTS
RH 3.4 Map21660.89UniSTS
Cytogenetic Map2q45UniSTS
RH131641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22249,043,716 - 249,043,897 (+)MAPPERmRatBN7.2
Rnor_6.02266,427,689 - 266,427,869NCBIRnor6.0
Rnor_5.02285,060,635 - 285,060,815UniSTSRnor5.0
RGSC_v3.42258,128,765 - 258,128,944UniSTSRGSC3.4
Celera2240,778,148 - 240,778,328UniSTS
Cytogenetic Map2q45UniSTS
RH131683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22249,047,008 - 249,047,189 (+)MAPPERmRatBN7.2
Rnor_6.02266,430,981 - 266,431,161NCBIRnor6.0
Rnor_5.02285,063,927 - 285,064,107UniSTSRnor5.0
Celera2240,781,440 - 240,781,620UniSTS
RH 3.4 Map21654.31UniSTS
Cytogenetic Map2q45UniSTS
RH135449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22249,042,999 - 249,043,218 (+)MAPPERmRatBN7.2
Rnor_6.02266,426,972 - 266,427,190NCBIRnor6.0
Rnor_5.02285,059,918 - 285,060,136UniSTSRnor5.0
RGSC_v3.42258,128,048 - 258,128,266UniSTSRGSC3.4
Celera2240,777,431 - 240,777,649UniSTS
Cytogenetic Map2q45UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 89 59 6 353 189 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000055245   ⟹   ENSRNOP00000052120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2251,590,614 - 251,706,380 (+)Ensembl
mRatBN7.2 Ensembl2248,931,903 - 249,048,298 (+)Ensembl
Rnor_6.0 Ensembl2266,315,036 - 266,431,216 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080305   ⟹   ENSRNOP00000073668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2251,624,162 - 251,706,380 (+)Ensembl
mRatBN7.2 Ensembl2248,965,421 - 249,048,298 (+)Ensembl
Rnor_6.0 Ensembl2266,317,745 - 266,432,558 (+)Ensembl
RefSeq Acc Id: NM_001085353   ⟹   NP_001078822
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82251,590,659 - 251,701,875 (+)NCBI
mRatBN7.22248,931,916 - 249,043,132 (+)NCBI
Dahl_SR_JrHsd2251,506,316 - 251,625,381 (+)NCBI
Lyon_Normotensive2251,628,136 - 251,747,175 (+)NCBI
Lyon_Hypertensive2251,226,142 - 251,345,193 (+)NCBI
F344_StmMcwi2177,577,690 - 177,696,757 (+)NCBI
Rnor_6.02266,315,042 - 266,427,104 (+)NCBI
Rnor_5.02284,950,842 - 285,064,166 (+)NCBI
RGSC_v3.42258,014,437 - 258,128,180 (+)RGD
Celera2240,667,937 - 240,777,563 (+)NCBI
Sequence:
RefSeq Acc Id: NM_199408   ⟹   NP_955440
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82251,590,653 - 251,705,991 (+)NCBI
mRatBN7.22248,931,910 - 249,047,248 (+)NCBI
Dahl_SR_JrHsd2251,506,310 - 251,629,486 (+)NCBI
Lyon_Normotensive2251,628,130 - 251,751,280 (+)NCBI
Lyon_Hypertensive2251,226,136 - 251,349,298 (+)NCBI
F344_StmMcwi2177,577,684 - 177,700,862 (+)NCBI
Rnor_6.02266,315,036 - 266,431,220 (+)NCBI
Rnor_5.02284,950,842 - 285,064,166 (+)NCBI
RGSC_v3.42258,014,437 - 258,128,180 (+)RGD
Celera2240,667,931 - 240,781,679 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102736   ⟹   XP_038958664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82251,590,768 - 251,701,778 (+)NCBI
mRatBN7.22248,931,900 - 249,043,035 (+)NCBI
RefSeq Acc Id: XM_039102737   ⟹   XP_038958665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82251,590,824 - 251,701,778 (+)NCBI
mRatBN7.22248,931,885 - 249,043,035 (+)NCBI
RefSeq Acc Id: NP_955440   ⟸   NM_199408
- UniProtKB: Q6P689 (UniProtKB/Swiss-Prot),   A0A0G2K645 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001078822   ⟸   NM_001085353
- UniProtKB: Q6P689 (UniProtKB/Swiss-Prot),   A0A0G2K645 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073668   ⟸   ENSRNOT00000080305
Ensembl Acc Id: ENSRNOP00000052120   ⟸   ENSRNOT00000055245
RefSeq Acc Id: XP_038958665   ⟸   XM_039102737
- Peptide Label: isoform X1
- UniProtKB: A6HWU8 (UniProtKB/TrEMBL),   A0A0G2K645 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958664   ⟸   XM_039102736
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K645 (UniProtKB/TrEMBL)
Protein Domains
Wntless GOLD   Wntless-like transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P689-F1-model_v2 AlphaFold Q6P689 1-541 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691845
Promoter ID:EPDNEW_R2369
Type:initiation region
Name:Wls_1
Description:wntless Wnt ligand secretion mediator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02266,315,019 - 266,315,079EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735139 AgrOrtholog
BioCyc Gene G2FUF-50682 BioCyc
Ensembl Genes ENSRNOG00000036816 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000055245 ENTREZGENE
  ENSRNOT00000055245.4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621215 IMAGE-MGC_LOAD
InterPro WLS-like_TM UniProtKB/Swiss-Prot
  WLS_GOLD UniProtKB/Swiss-Prot
  Wntless UniProtKB/Swiss-Prot
KEGG Report rno:362065 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72636 IMAGE-MGC_LOAD
NCBI Gene 362065 ENTREZGENE
PANTHER PROTEIN WNTLESS HOMOLOG UniProtKB/Swiss-Prot
  PTHR13449 UniProtKB/Swiss-Prot
Pfam MIG-14_Wnt-bd UniProtKB/Swiss-Prot
  WLS_GOLD UniProtKB/Swiss-Prot
PhenoGen Wls PhenoGen
RatGTEx ENSRNOG00000036816 RatGTEx
UniProt A0A0G2K645 ENTREZGENE, UniProtKB/TrEMBL
  A0A8A1UKH9_RAT UniProtKB/TrEMBL
  A6HWU8 ENTREZGENE, UniProtKB/TrEMBL
  Q6P689 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Wls  Wnt ligand secretion mediator  LOC108350151  uncharacterized LOC108350151  Data merged from RGD:11514906 737654 PROVISIONAL
2018-12-04 Wls  Wnt ligand secretion mediator  Wls  wntless Wnt ligand secretion mediator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 LOC108350151  uncharacterized LOC108350151      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-11-11 Wls  wntless Wnt ligand secretion mediator  Wls  wntless homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Wls  wntless homolog (Drosophila)  Gpr177  G protein-coupled receptor 177  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Gpr177  G protein-coupled receptor 177  LOC362065  CG6210-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 LOC362065        Symbol and Name status set to provisional 70820 PROVISIONAL