Rnasel (ribonuclease L) - Rat Genome Database

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Pathways
Gene: Rnasel (ribonuclease L) Rattus norvegicus
Analyze
Symbol: Rnasel
Name: ribonuclease L
RGD ID: 727933
Description: Enables RNA nuclease activity and rRNA binding activity. Involved in rRNA processing. Located in nuclear matrix. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L); PARTICIPATES IN hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-5A-dependent ribonuclease; ribonuclease L (2 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,446,641 - 68,460,804 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1368,446,882 - 68,459,557 (+)EnsemblGRCr8
mRatBN7.21365,894,990 - 65,910,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,901,459 - 65,908,704 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1368,502,520 - 68,509,768 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,792,702 - 69,799,948 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01367,049,541 - 67,056,829 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,188,712 - 71,202,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,192,142 - 71,202,625 (+)Ensemblrn6Rnor6.0
Rnor_5.01376,153,998 - 76,167,666 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,822,013 - 68,829,264 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,801,918 - 65,809,169 (+)NCBICelera
RGSC_v3.11368,836,092 - 68,843,336 (+)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nuclear matrix  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. Al-Khatib K, etal., Exp Eye Res. 2005 Feb;80(2):167-73. doi: 10.1016/j.exer.2004.08.026.
2. RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Casey G, etal., Nat Genet. 2002 Dec;32(4):581-3. Epub 2002 Nov 4.
3. Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer. Downing SR, etal., Clin Prostate Cancer. 2003 Dec;2(3):177-80.
4. Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L. Duerst RJ and Morrison LA, Virology. 2007 Apr 10;360(2):322-8. doi: 10.1016/j.virol.2006.10.042. Epub 2006 Dec 6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L. Goldstein SA, etal., J Virol. 2017 Feb 14;91(5). pii: JVI.02201-16. doi: 10.1128/JVI.02201-16. Print 2017 Mar 1.
8. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. Guidotti LG, etal., J Virol. 2002 Mar;76(6):2617-21. doi: 10.1128/jvi.76.6.2617-2621.2002.
9. Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. Jha BK, etal., J Biol Chem. 2011 Jul 29;286(30):26319-26. doi: 10.1074/jbc.M111.253443. Epub 2011 Jun 2.
10. Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. Kruger S, etal., Lancet Oncol. 2005 Aug;6(8):566-72.
11. Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection. Li SX, etal., Virology. 2013 Aug 15;443(1):134-42. doi: 10.1016/j.virol.2013.05.009. Epub 2013 May 29.
12. An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. Li XL, etal., Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20816-21. doi: 10.1073/pnas.0807265105. Epub 2008 Dec 15.
13. RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer. Long TM, etal., Inflamm Bowel Dis. 2013 May;19(6):1295-305. doi: 10.1097/MIB.0b013e318281f2fd.
14. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Evidence for age-dependent impairment of antiviral 2',5'-oligoadenylate synthetase/ribonuclease L-system in tissues of rat. Pfeifer K, etal., Mech Ageing Dev. 1993 Feb;67(1-2):101-14.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice. Rice AD, etal., J Virol. 2011 Jan;85(1):550-67. doi: 10.1128/JVI.00254-10. Epub 2010 Oct 13.
22. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. Samuel MA, etal., J Virol. 2006 Jul;80(14):7009-19. doi: 10.1128/JVI.00489-06.
23. Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer. Sevinc A, etal., Anticancer Res. 2004 Jul-Aug;24(4):2547-9.
24. Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation. Thornbrough JM, etal., mBio. 2016 Mar 29;7(2):e00258. doi: 10.1128/mBio.00258-16.
25. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. Xiang Y, etal., J Virol. 2002 May;76(10):5251-9. doi: 10.1128/jvi.76.10.5251-5259.2002.
26. Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. Zhou Y, etal., J Immunol. 2013 Sep 1;191(5):2637-46. doi: 10.4049/jimmunol.1300082. Epub 2013 Aug 2.
Additional References at PubMed
PMID:7514601   PMID:12477932   PMID:19245366   PMID:19923450   PMID:22441668   PMID:24578532  


Genomics

Comparative Map Data
Rnasel
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,446,641 - 68,460,804 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1368,446,882 - 68,459,557 (+)EnsemblGRCr8
mRatBN7.21365,894,990 - 65,910,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,901,459 - 65,908,704 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1368,502,520 - 68,509,768 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,792,702 - 69,799,948 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01367,049,541 - 67,056,829 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,188,712 - 71,202,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,192,142 - 71,202,625 (+)Ensemblrn6Rnor6.0
Rnor_5.01376,153,998 - 76,167,666 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,822,013 - 68,829,264 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,801,918 - 65,809,169 (+)NCBICelera
RGSC_v3.11368,836,092 - 68,843,336 (+)NCBI
Cytogenetic Map13q21NCBI
RNASEL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,573,634 - 182,589,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,573,634 - 182,589,272 (-)Ensemblhg38GRCh38
GRCh371182,542,769 - 182,558,391 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,809,395 - 180,822,731 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341179,274,428 - 179,287,765NCBI
Celera1155,654,005 - 155,667,341 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,779,235 - 153,794,860 (-)NCBIHuRef
CHM1_11183,966,207 - 183,981,832 (-)NCBICHM1_1
T2T-CHM13v2.01181,933,110 - 181,948,734 (-)NCBIT2T-CHM13v2.0
Rnasel
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,625,089 - 153,644,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,625,172 - 153,639,967 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,749,344 - 153,768,690 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,749,426 - 153,764,221 (+)Ensemblmm10GRCm38
MGSCv371155,596,556 - 155,611,351 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361155,515,149 - 155,524,559 (+)NCBIMGSCv36mm8
Celera1156,181,252 - 156,196,205 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.43NCBI
Rnasel
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,411,980 - 21,425,052 (-)Ensembl
ChiLan1.0NW_00495540621,413,950 - 21,424,860 (-)NCBIChiLan1.0ChiLan1.0
RNASEL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2167,139,920 - 67,155,657 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,823,513 - 66,839,195 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,092,346 - 158,108,026 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,744,169 - 161,759,741 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,741,645 - 161,760,045 (-)EnsemblpanPan2panpan1.1
RNASEL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1715,978,055 - 16,001,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl715,856,151 - 16,001,569 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha715,566,511 - 15,588,072 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0715,706,990 - 15,731,063 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,584,822 - 15,731,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,621,143 - 15,642,651 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,729,189 - 15,750,983 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0715,858,335 - 15,880,030 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rnasel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,316,525 - 89,330,595 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364817,165,353 - 7,177,538 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364817,165,400 - 7,177,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASEL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9123,893,294 - 123,910,398 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19123,895,045 - 123,910,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29136,210,085 - 136,224,410 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RNASEL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,779,221 - 46,795,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,779,700 - 46,795,842 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605547,997,591 - 48,013,734 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnasel
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481411,268,698 - 11,305,221 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462481411,268,725 - 11,319,023 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rnasel
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11033,204,912 - 33,214,691 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rnasel
84 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:162
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000032157
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_182673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY262823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000032157   ⟹   ENSRNOP00000032975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1368,446,882 - 68,459,557 (+)Ensembl
mRatBN7.2 Ensembl1365,901,459 - 65,908,704 (+)Ensembl
Rnor_6.0 Ensembl1371,192,142 - 71,202,625 (+)Ensembl
RefSeq Acc Id: NM_182673   ⟹   NP_872614
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,451,911 - 68,459,162 (+)NCBI
mRatBN7.21365,901,461 - 65,908,712 (+)NCBI
Rnor_6.01371,193,743 - 71,200,994 (+)NCBI
Rnor_5.01376,153,998 - 76,167,666 (+)NCBI
RGSC_v3.41368,822,013 - 68,829,264 (+)RGD
Celera1365,801,918 - 65,809,169 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249999   ⟹   XP_006250061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,653 - 68,460,804 (+)NCBI
mRatBN7.21365,895,007 - 65,910,354 (+)NCBI
Rnor_6.01371,188,712 - 71,202,636 (+)NCBI
Rnor_5.01376,153,998 - 76,167,666 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250004   ⟹   XP_006250066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,641 - 68,457,662 (+)NCBI
mRatBN7.21365,894,990 - 65,907,216 (+)NCBI
Rnor_6.01371,188,712 - 71,199,505 (+)NCBI
Rnor_5.01376,153,998 - 76,167,666 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090867   ⟹   XP_038946795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,644 - 68,460,804 (+)NCBI
mRatBN7.21365,894,993 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090868   ⟹   XP_038946796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,447,254 - 68,460,804 (+)NCBI
mRatBN7.21365,899,148 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090869   ⟹   XP_038946797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,450,169 - 68,460,804 (+)NCBI
mRatBN7.21365,899,781 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090870   ⟹   XP_038946798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,644 - 68,460,804 (+)NCBI
mRatBN7.21365,894,993 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090871   ⟹   XP_038946799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,449,863 - 68,460,804 (+)NCBI
mRatBN7.21365,899,413 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090872   ⟹   XP_038946800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,641 - 68,460,804 (+)NCBI
mRatBN7.21365,894,991 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090873   ⟹   XP_038946801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,642 - 68,460,804 (+)NCBI
mRatBN7.21365,894,991 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_039090874   ⟹   XP_038946802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,642 - 68,460,804 (+)NCBI
mRatBN7.21365,894,991 - 65,910,354 (+)NCBI
RefSeq Acc Id: XM_063272421   ⟹   XP_063128491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,644 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272423   ⟹   XP_063128493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,644 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272424   ⟹   XP_063128494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,447,254 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272425   ⟹   XP_063128495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,447,003 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272426   ⟹   XP_063128496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,653 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272427   ⟹   XP_063128497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,447,255 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272428   ⟹   XP_063128498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,653 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272429   ⟹   XP_063128499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,653 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272430   ⟹   XP_063128500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,450,193 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272431   ⟹   XP_063128501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,653 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272432   ⟹   XP_063128502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,447,255 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272433   ⟹   XP_063128503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,449,863 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272434   ⟹   XP_063128504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,651 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272435   ⟹   XP_063128505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,651 - 68,460,804 (+)NCBI
RefSeq Acc Id: XM_063272436   ⟹   XP_063128506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,446,650 - 68,460,804 (+)NCBI
Protein Sequences
Protein RefSeqs NP_872614 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250061 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250066 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946795 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946796 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946797 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946798 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946799 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946800 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946801 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946802 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128491 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128493 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128494 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128495 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128496 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128497 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128498 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128499 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128500 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128501 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128502 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128503 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128504 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128505 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128506 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP22025 (Get FASTA)   NCBI Sequence Viewer  
  EDM09538 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032975
  ENSRNOP00000032975.3
RefSeq Acc Id: NP_872614   ⟸   NM_182673
- Sequence:
RefSeq Acc Id: XP_006250061   ⟸   XM_006249999
- Peptide Label: isoform X2
- UniProtKB: G3V915 (UniProtKB/TrEMBL),   A6ICV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250066   ⟸   XM_006250004
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000032975   ⟸   ENSRNOT00000032157
RefSeq Acc Id: XP_038946800   ⟸   XM_039090872
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946801   ⟸   XM_039090873
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946802   ⟸   XM_039090874
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946795   ⟸   XM_039090867
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946798   ⟸   XM_039090870
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946796   ⟸   XM_039090868
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946799   ⟸   XM_039090871
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946797   ⟸   XM_039090869
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128491   ⟸   XM_063272421
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128493   ⟸   XM_063272423
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128506   ⟸   XM_063272436
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128504   ⟸   XM_063272434
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128505   ⟸   XM_063272435
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128496   ⟸   XM_063272426
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128498   ⟸   XM_063272428
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128499   ⟸   XM_063272429
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128501   ⟸   XM_063272431
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128495   ⟸   XM_063272425
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128494   ⟸   XM_063272424
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128497   ⟸   XM_063272427
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128502   ⟸   XM_063272432
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128503   ⟸   XM_063272433
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128500   ⟸   XM_063272430
- Peptide Label: isoform X2
- UniProtKB: A6ICV9 (UniProtKB/TrEMBL),   G3V915 (UniProtKB/TrEMBL)
Protein Domains
KEN   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V915-F1-model_v2 AlphaFold G3V915 1-738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727933 AgrOrtholog
BioCyc Gene G2FUF-17876 BioCyc
Ensembl Genes ENSRNOG00000027017 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032157 ENTREZGENE
  ENSRNOT00000032157.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.180 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  KEN_RNase_activator UniProtKB/TrEMBL
  KEN_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  RNase-L_RNase UniProtKB/TrEMBL
KEGG Report rno:359726 UniProtKB/TrEMBL
NCBI Gene 359726 ENTREZGENE
PANTHER 2-5A-DEPENDENT RIBONUCLEASE UniProtKB/TrEMBL
  2-5A-DEPENDENT RIBONUCLEASE UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Ribonuc_2-5A UniProtKB/TrEMBL
PhenoGen Rnasel PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  KEN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027017 RatGTEx
SMART ANK UniProtKB/TrEMBL
  PUG UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A6ICV9 ENTREZGENE, UniProtKB/TrEMBL
  G3V915 ENTREZGENE, UniProtKB/TrEMBL
  Q80WM6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Rnasel  ribonuclease L  Rnasel  ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rnasel  ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)    ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent)  Name updated 1299863 APPROVED