Klk1c9 (kallikrein 1-related peptidase C9) - Rat Genome Database

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Gene: Klk1c9 (kallikrein 1-related peptidase C9) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klk1c9
Name: kallikrein 1-related peptidase C9
RGD ID: 727805
Description: Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of vasoconstriction. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH aristolochic acid A; cyclosporin A; diuron.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kallikrein a2; kallikrein, submaxillary gland S3; KLK-S3; Klk9; Klks3; Klna2; LOC292868; rGK-9; rK9; S3 kallikrein; SEV; submandibular enzymatic vasoconstrictor; submandibular glandular kallikrein-9; submaxillary gland S3 kallikrein; tissue kallikrein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,733,870 - 103,737,756 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,727,746 - 103,737,756 (+)EnsemblGRCr8
mRatBN7.2194,597,359 - 94,601,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,597,359 - 94,601,245 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,982,736 - 99,986,626 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,455,371 - 108,459,259 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,746,010 - 101,749,912 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,086,520 - 100,090,406 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)Ensemblrn6Rnor6.0
Rnor_5.01101,151,631 - 101,155,517 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,579,471 - 94,583,357 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,864,237 - 88,868,123 (+)NCBICelera
RGSC_v3.1194,657,581 - 94,661,468 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4512-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. A novel serine protease with vasoconstrictor activity coded by the kallikrein gene S3. Yamaguchi T, etal., J Biol Chem 1991 Mar 15;266(8):5011-7.
Additional References at PubMed
PMID:1315752   PMID:1536657   PMID:15203212   PMID:15489334   PMID:17366701  


Genomics

Variants

.
Variants in Klk1c9
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:79
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000025723
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Mit20  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01100,372,157 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,236 - 101,154,356NCBIRnor5.0
Rnor_5.01100,934,189 - 100,934,363NCBIRnor5.0
Rnor_5.01100,934,188 - 100,934,363NCBIRnor5.0
Rnor_5.01100,372,156 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,235 - 101,154,356NCBIRnor5.0
RGSC_v3.4194,582,077 - 94,582,196UniSTSRGSC3.4
RGSC_v3.4194,582,076 - 94,582,196RGDRGSC3.4
RGSC_v3.4194,356,875 - 94,357,049RGDRGSC3.4
RGSC_v3.4194,356,876 - 94,357,049UniSTSRGSC3.4
Celera188,866,843 - 88,866,962UniSTS
Celera188,646,815 - 88,646,988UniSTS
RGSC_v3.1194,660,187 - 94,660,307RGD
RH 3.4 Map1905.2RGD
RH 3.4 Map1905.2UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
3 11 17 22 23 28 11 19 11 123 45 2 16 56 36 17

Sequence


Ensembl Acc Id: ENSRNOT00000025723   ⟹   ENSRNOP00000025723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,733,870 - 103,737,756 (+)Ensembl
mRatBN7.2 Ensembl194,597,359 - 94,601,245 (+)Ensembl
Rnor_6.0 Ensembl1100,086,520 - 100,090,406 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025831   ⟹   ENSRNOP00000025831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,199,057 - 100,203,260 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071416   ⟹   ENSRNOP00000066004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,131,562 - 100,135,556 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081095   ⟹   ENSRNOP00000070080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,059,967 - 100,135,673 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091964   ⟹   ENSRNOP00000073798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,131,449 - 100,203,329 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103423   ⟹   ENSRNOP00000096240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,735,372 - 103,737,756 (+)Ensembl
mRatBN7.2 Ensembl194,598,861 - 94,601,245 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115796   ⟹   ENSRNOP00000078732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,727,746 - 103,737,756 (+)Ensembl
RefSeq Acc Id: NM_175759   ⟹   NP_786935
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,733,870 - 103,737,756 (+)NCBI
mRatBN7.2194,597,359 - 94,601,245 (+)NCBI
Rnor_6.01100,086,520 - 100,090,406 (+)NCBI
Rnor_5.01101,151,631 - 101,155,517 (+)NCBI
RGSC_v3.4194,579,471 - 94,583,357 (+)RGD
Celera188,864,237 - 88,868,123 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_786935 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41467 (Get FASTA)   NCBI Sequence Viewer  
  AAH61771 (Get FASTA)   NCBI Sequence Viewer  
  EDM07521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025723
  ENSRNOP00000025723.2
GenBank Protein P07647 (Get FASTA)   NCBI Sequence Viewer  
  SFW93258 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_786935   ⟸   NM_175759
- Peptide Label: precursor
- UniProtKB: P07647 (UniProtKB/Swiss-Prot),   A0A1R3UCK3 (UniProtKB/TrEMBL),   A0A8I6ASZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066004   ⟸   ENSRNOT00000071416
Ensembl Acc Id: ENSRNOP00000070080   ⟸   ENSRNOT00000081095
Ensembl Acc Id: ENSRNOP00000025723   ⟸   ENSRNOT00000025723
Ensembl Acc Id: ENSRNOP00000025831   ⟸   ENSRNOT00000025831
Ensembl Acc Id: ENSRNOP00000073798   ⟸   ENSRNOT00000091964
Ensembl Acc Id: ENSRNOP00000096240   ⟸   ENSRNOT00000103423
Ensembl Acc Id: ENSRNOP00000078732   ⟸   ENSRNOT00000115796
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07647-F1-model_v2 AlphaFold P07647 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689993
Promoter ID:EPDNEW_R517
Type:multiple initiation site
Name:Klk1b3_2
Description:kallikrein 1-related peptidase B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R518  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,086,514 - 100,086,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727805 AgrOrtholog
BioCyc Gene G2FUF-59801 BioCyc
Ensembl Genes ENSRNOG00000032857 Ensembl
  ENSRNOG00000067884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025723 ENTREZGENE
  ENSRNOT00000025723.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621994 IMAGE-MGC_LOAD
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:292868 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72263 IMAGE-MGC_LOAD
NCBI Gene 292868 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Klk1c9 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032857 RatGTEx
  ENSRNOG00000067884 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A1R3UCK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASZ7 ENTREZGENE, UniProtKB/TrEMBL
  KLK9_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-29 Klk1c9  kallikrein 1-related peptidase C9  Klks3  kallikrein, submaxillary gland S3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Klks3  kallikrein, submaxillary gland S3  LOC292868  submaxillary gland S3 kallikrein  Symbol and Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the submaxillary gland and prostate 1302426
gene_homology protein is 84% homologous to rat submaxillary tonin 633345
gene_protein 29 kDa protein appears to consist of an approximately 19.9 kDa heavy chain and 10.7 kDa light chain, possibly as a result of post-translational peptide cleavage; the pI of the disulfide bonded heterodimer is 7.36 1302426