Prdx6 (peroxiredoxin 6) - Rat Genome Database

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Gene: Prdx6 (peroxiredoxin 6) Rattus norvegicus
Analyze
Symbol: Prdx6
Name: peroxiredoxin 6
RGD ID: 71005
Description: Enables 1-acylglycerophosphocholine O-acyltransferase activity and glutathione peroxidase activity. Involved in hydrogen peroxide catabolic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human PRDX6 (peroxiredoxin 6); PARTICIPATES IN phenylalanine metabolic pathway; INTERACTS WITH (R)-adrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-Cys peroxiredoxin; 1-Cys PRX; acidic calcium-independent phospholipase A2; aiPLA2; antioxidant protein 2; glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; NSGPx; peroxiredoxin-6; thiol-specific antioxidant protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,062,082 - 76,072,631 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1376,061,554 - 76,072,657 (-)EnsemblGRCr8
mRatBN7.21373,528,746 - 73,539,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,528,210 - 73,539,355 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1376,121,248 - 76,131,824 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,405,434 - 77,415,988 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,665,337 - 74,675,890 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,077,567 - 79,088,113 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,077,033 - 79,088,127 (-)Ensemblrn6Rnor6.0
Rnor_5.01383,972,564 - 83,983,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41376,824,968 - 76,835,517 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1373,317,100 - 73,327,649 (-)NCBICelera
RGSC_v3.11376,838,625 - 76,849,719 (-)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorophyllin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ferrostatin-1  (ISO)
flutamide  (EXP)
folic acid  (EXP)
fructose  (EXP)
fumonisin B1  (ISO)
furfural  (ISO)
glutathione  (EXP)
GSK-J4  (ISO)
herbicide  (ISO)
homocysteine  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methylene blue  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
Nonylphenol  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
picloram  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
Propiverine  (EXP)
Pyridostigmine bromide  (EXP)
pyrogallol  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichlopyr  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO)
lysosome  (IEA)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat. Acar N, etal., Acta Histochem. 2014 Oct;116(8):1289-300. doi: 10.1016/j.acthis.2014.07.012. Epub 2014 Aug 27.
2. Study of structure of secretory 28 kDa protein from the rat olfactory epithelium Andreeva SG, etal., Bioorg Khim 1998 Nov;24(11):816-21.
3. A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. Fisher AB, etal., J Lipid Res. 2016 Apr;57(4):587-96. doi: 10.1194/jlr.M064758. Epub 2016 Feb 1.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. TARGETED DISRUPTION OF PEROXIREDOXIN 6 GENE RENDERS THE HEART VULNERABLE TO ISCHEMIA REPERFUSION INJURY. Nagy N, etal., Am J Physiol Heart Circ Physiol. 2006 Jun 9;.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. Nilsson A, etal., J Proteome Res. 2007 Oct;6(10):3952-61. Epub 2007 Sep 18.
12. Novel 28-kDa secretory protein from rat olfactory epithelium. Peshenko IV, etal., FEBS Lett 1996 Feb 26;381(1-2):12-14.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3epsilon. Sorokina EM, etal., Am J Physiol Cell Physiol. 2011 Jun;300(6):C1430-41. doi: 10.1152/ajpcell.00285.2010. Epub 2011 Feb 23.
17. Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Wang X, etal., Atherosclerosis. 2004 Nov;177(1):61-70.
Additional References at PubMed
PMID:8999971   PMID:9587003   PMID:10893423   PMID:12732627   PMID:16186110   PMID:16330552   PMID:17135244   PMID:17556052   PMID:17633531   PMID:17652308   PMID:18184874   PMID:18614015  
PMID:18694738   PMID:19056867   PMID:19140803   PMID:19188445   PMID:19351539   PMID:19725078   PMID:19946888   PMID:20458337   PMID:20716133   PMID:22166015   PMID:22663767   PMID:23376485  
PMID:23533145   PMID:23580065   PMID:23623867   PMID:24447893   PMID:25468996   PMID:25938937   PMID:27412928   PMID:27660222   PMID:28596967   PMID:29476059   PMID:31238863   PMID:32018008  
PMID:33159299   PMID:34482185   PMID:34863856   PMID:36209344   PMID:36401357   PMID:38530594  


Genomics

Comparative Map Data
Prdx6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,062,082 - 76,072,631 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1376,061,554 - 76,072,657 (-)EnsemblGRCr8
mRatBN7.21373,528,746 - 73,539,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,528,210 - 73,539,355 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1376,121,248 - 76,131,824 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,405,434 - 77,415,988 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,665,337 - 74,675,890 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,077,567 - 79,088,113 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,077,033 - 79,088,127 (-)Ensemblrn6Rnor6.0
Rnor_5.01383,972,564 - 83,983,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41376,824,968 - 76,835,517 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1373,317,100 - 73,327,649 (-)NCBICelera
RGSC_v3.11376,838,625 - 76,849,719 (-)NCBI
Cytogenetic Map13q22NCBI
PRDX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,477,335 - 173,488,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,476,814 - 173,489,064 (+)Ensemblhg38GRCh38
GRCh371173,446,474 - 173,457,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,713,109 - 171,724,569 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1146,555,898 - 146,567,358 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1144,671,177 - 144,682,637 (+)NCBIHuRef
CHM1_11174,868,919 - 174,880,398 (+)NCBICHM1_1
T2T-CHM13v2.01172,835,491 - 172,846,972 (+)NCBIT2T-CHM13v2.0
Prdx6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,067,682 - 161,078,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,067,682 - 161,078,789 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381161,240,112 - 161,251,210 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,240,112 - 161,251,219 (-)Ensemblmm10GRCm38
MGSCv371163,170,243 - 163,181,297 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361163,076,789 - 163,087,843 (-)NCBIMGSCv36mm8
Celera1163,685,242 - 163,696,325 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Prdx6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,717,267 - 13,728,216 (+)Ensembl
ChiLan1.0NW_00495540613,717,267 - 13,728,216 (+)NCBIChiLan1.0ChiLan1.0
PRDX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2176,243,727 - 76,255,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1175,917,520 - 75,929,098 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,988,836 - 149,000,345 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11152,694,606 - 152,706,521 (+)NCBIPanPan1.1PanPan1.1panPan2
PRDX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,663,238 - 25,675,855 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,663,579 - 25,675,754 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha725,195,499 - 25,208,542 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0725,414,335 - 25,427,625 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl725,410,888 - 25,427,580 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,333,015 - 25,346,019 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0725,411,171 - 25,424,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0725,560,133 - 25,573,439 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prdx6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,376,675 - 96,386,886 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648114,222,696 - 14,233,641 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648114,223,422 - 14,233,634 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,857,644 - 115,868,892 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19115,857,629 - 115,868,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,491,864 - 127,503,134 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12555,706,920 - 55,719,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2555,706,885 - 55,718,665 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605557,279,199 - 57,290,948 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247718,282,062 - 8,294,340 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247718,282,622 - 8,293,799 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prdx6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11040,540,073 - 40,551,238 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prdx6
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000034583
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH128089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,528,768 - 73,528,964 (+)MAPPERmRatBN7.2
mRatBN7.21053,609,492 - 53,609,702 (+)MAPPERmRatBN7.2
Rnor_6.01055,491,074 - 55,491,283NCBIRnor6.0
Rnor_6.01379,077,590 - 79,077,785NCBIRnor6.0
Rnor_5.01383,972,587 - 83,972,782UniSTSRnor5.0
Rnor_5.01055,233,453 - 55,233,662UniSTSRnor5.0
RGSC_v3.41055,660,814 - 55,661,023UniSTSRGSC3.4
RGSC_v3.41376,824,991 - 76,825,186UniSTSRGSC3.4
Celera1373,317,123 - 73,317,318UniSTS
Celera1052,775,812 - 52,776,021UniSTS
Cytogenetic Map13q22UniSTS
Cytogenetic Map10q24UniSTS
RH134407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,528,230 - 73,528,413 (+)MAPPERmRatBN7.2
mRatBN7.21053,608,960 - 53,609,144 (+)MAPPERmRatBN7.2
Rnor_6.01055,490,542 - 55,490,725NCBIRnor6.0
Rnor_6.01379,077,053 - 79,077,235NCBIRnor6.0
Rnor_5.01383,972,050 - 83,972,232UniSTSRnor5.0
Rnor_5.01055,232,921 - 55,233,104UniSTSRnor5.0
RGSC_v3.41055,660,282 - 55,660,465UniSTSRGSC3.4
RGSC_v3.41376,824,454 - 76,824,636UniSTSRGSC3.4
Celera1373,316,586 - 73,316,768UniSTS
Celera1052,775,280 - 52,775,463UniSTS
RH 3.4 Map13447.6UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map13q22UniSTS
BE116085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,533,843 - 73,534,023 (+)MAPPERmRatBN7.2
Rnor_6.01379,082,665 - 79,082,844NCBIRnor6.0
Rnor_5.01383,977,662 - 83,977,841UniSTSRnor5.0
RGSC_v3.41376,830,066 - 76,830,245UniSTSRGSC3.4
Celera1373,322,198 - 73,322,377UniSTS
RH 3.4 Map13441.5UniSTS
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034583   ⟹   ENSRNOP00000030323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1379,077,033 - 79,088,127 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1379,079,283 - 79,080,055 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100083   ⟹   ENSRNOP00000084274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1373,528,210 - 73,538,736 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117915   ⟹   ENSRNOP00000085822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1373,528,445 - 73,539,355 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165363   ⟹   ENSRNOP00000103996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1376,061,554 - 76,072,657 (-)Ensembl
RefSeq Acc Id: NM_053576   ⟹   NP_446028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,062,082 - 76,072,631 (-)NCBI
mRatBN7.21373,528,746 - 73,539,295 (-)NCBI
Rnor_6.01379,077,567 - 79,088,113 (-)NCBI
Rnor_5.01383,972,564 - 83,983,110 (-)NCBI
RGSC_v3.41376,824,968 - 76,835,517 (-)RGD
Celera1373,317,100 - 73,327,649 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB66341 (Get FASTA)   NCBI Sequence Viewer  
  CAA76732 (Get FASTA)   NCBI Sequence Viewer  
  EDM09416 (Get FASTA)   NCBI Sequence Viewer  
  EDM09417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000103996
GenBank Protein O35244 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446028   ⟸   NM_053576
- UniProtKB: O35244 (UniProtKB/Swiss-Prot),   A6ID81 (UniProtKB/TrEMBL),   A0A8I5ZYW1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030323   ⟸   ENSRNOT00000034583
Ensembl Acc Id: ENSRNOP00000085822   ⟸   ENSRNOT00000117915
Ensembl Acc Id: ENSRNOP00000084274   ⟸   ENSRNOT00000100083
Ensembl Acc Id: ENSRNOP00000103996   ⟸   ENSRNOT00000165363
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35244-F1-model_v2 AlphaFold O35244 1-224 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698932
Promoter ID:EPDNEW_R9457
Type:initiation region
Name:Prdx6_1
Description:peroxiredoxin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01379,088,142 - 79,088,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71005 AgrOrtholog
BioCyc Gene G2FUF-17724 BioCyc
Ensembl Genes ENSRNOG00000002896 Ensembl
  ENSRNOG00000066585 Ensembl
  ENSRNOG00000081976 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000165363 ENTREZGENE
Gene3D-CATH Antioxidant, Horf6, Chain A, domain2 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro AhpC/TSA UniProtKB/Swiss-Prot
  Peroxiredoxin_AhpC-typ UniProtKB/Swiss-Prot
  Peroxiredoxin_C UniProtKB/Swiss-Prot
  PRX_1cys UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:94167 UniProtKB/Swiss-Prot
NCBI Gene 94167 ENTREZGENE
PANTHER MCG48959-RELATED UniProtKB/Swiss-Prot
  PEROXIREDOXIN-6 UniProtKB/Swiss-Prot
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot
  AhpC-TSA UniProtKB/Swiss-Prot
PhenoGen Prdx6 PhenoGen
PIRSF AHPC UniProtKB/Swiss-Prot
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002896 RatGTEx
  ENSRNOG00000066585 RatGTEx
  ENSRNOG00000081976 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYW1 ENTREZGENE
  A6ID80_RAT UniProtKB/TrEMBL
  A6ID81 ENTREZGENE, UniProtKB/TrEMBL
  O35244 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prdx6  peroxiredoxin 6      Symbol and Name status set to approved 1299863 APPROVED
2003-05-22 Prdx6  peroxiredoxin 6  Prdx5  peroxiredoxin 5  Symbol and Name updated to reflect Human and Mouse nomenclature 629527 PROVISIONAL
2002-07-09 Prdx5  peroxiredoxin 5      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference