Bok (BCL2 family apoptosis regulator BOK) - Rat Genome Database

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Gene: Bok (BCL2 family apoptosis regulator BOK) Rattus norvegicus
Analyze
Symbol: Bok
Name: BCL2 family apoptosis regulator BOK
RGD ID: 70984
Description: Enables BH domain binding activity and protein heterodimerization activity. Involved in several processes, including male gonad development; oligodendrocyte differentiation; and response to cisplatin. Predicted to be located in several cellular components, including bounding membrane of organelle; mitochondrial inner membrane; and trans-Golgi network membrane. Predicted to be active in mitochondrial outer membrane. Biomarker of hydrocephalus. Orthologous to human BOK (BCL2 family apoptosis regulator BOK); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bcl-2-related ovarian killer protein; BCL2-related ovarian killer; BOK, BCL2 family apoptosis regulator; Bok-BH3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,670,729 - 101,681,834 (+)NCBIGRCr8
mRatBN7.2994,223,493 - 94,234,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,223,389 - 94,234,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,659,055 - 102,669,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,794,662 - 107,805,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,150,763 - 106,161,668 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,829,593 - 100,840,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,829,552 - 100,840,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,482,657 - 100,493,563 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,970,069 - 92,980,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,174,837 - 93,185,742 (+)NCBI
Celera991,758,055 - 91,768,960 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buprofezin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diepoxybutane  (ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (EXP)
epichlorohydrin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
ferroheme b  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
glyphosate  (EXP)
heme b  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
Myrtucommulone A  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IDA,IMP,ISO)
cellular component disassembly involved in execution phase of apoptosis  (ISO,ISS)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA)
male gonad development  (IEP)
negative regulation of mitochondrial depolarization  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron apoptotic process  (ISO)
oligodendrocyte differentiation  (IEP)
positive regulation of apoptotic process  (IBA,IDA,ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO,ISS)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO,ISS)
positive regulation of execution phase of apoptosis  (ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (ISO,ISS)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO,ISS)
positive regulation of PERK-mediated unfolded protein response  (ISO,ISS)
protein complex oligomerization  (ISO,ISS)
regulation of autophagy  (ISO)
regulation of chorionic trophoblast cell proliferation  (ISO,ISS)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of granulosa cell apoptotic process  (ISO,ISS)
release of cytochrome c from mitochondria  (IBA,ISO)
response to cisplatin  (IEP)
transmembrane transport  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro. Hsu SY and Hsueh AJ, J Biol Chem. 1998 Nov 13;273(46):30139-46.
5. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
6. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
7. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
8. Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Manohar S, etal., Neurotox Res. 2014 May;25(4):369-80. doi: 10.1007/s12640-013-9443-y. Epub 2013 Nov 26.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus. Morgan FW, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):273-90.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. The expression and regulation of Bcl-2-related ovarian killer (Bok) mRNA in the developing and adult rat testis. Suominen JS, etal., Eur J Endocrinol. 2001 Dec;145(6):771-8.
Additional References at PubMed
PMID:9535847   PMID:15102863   PMID:15489334   PMID:15868100   PMID:16302269   PMID:19095301   PMID:19942931   PMID:20673843   PMID:23429263   PMID:23884412   PMID:24113155   PMID:26015568  
PMID:26949185   PMID:27098698   PMID:27505430  


Genomics

Comparative Map Data
Bok
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,670,729 - 101,681,834 (+)NCBIGRCr8
mRatBN7.2994,223,493 - 94,234,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,223,389 - 94,234,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,659,055 - 102,669,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,794,662 - 107,805,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,150,763 - 106,161,668 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,829,593 - 100,840,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,829,552 - 100,840,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,482,657 - 100,493,563 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,970,069 - 92,980,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,174,837 - 93,185,742 (+)NCBI
Celera991,758,055 - 91,768,960 (+)NCBICelera
Cytogenetic Map9q36NCBI
BOK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,551,393 - 241,574,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,551,424 - 241,574,131 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,498,160 - 242,513,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,146,865 - 242,162,226 (+)NCBINCBI36Build 36hg18NCBI36
Build 342242,218,181 - 242,233,541NCBI
Celera2236,166,128 - 236,181,243 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,252,352 - 234,267,504 (+)NCBIHuRef
CHM1_12242,504,201 - 242,519,152 (+)NCBICHM1_1
T2T-CHM13v2.02242,051,239 - 242,074,030 (+)NCBIT2T-CHM13v2.0
Bok
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,613,297 - 93,623,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,613,382 - 93,623,486 (+)EnsemblGRCm39 Ensembl
GRCm38193,685,575 - 93,695,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,685,660 - 93,695,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,582,271 - 95,592,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,516,100 - 95,526,168 (+)NCBIMGSCv36mm8
Celera196,630,738 - 96,640,880 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.28NCBI
Bok
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542224,471 - 232,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955542224,471 - 232,401 (-)NCBIChiLan1.0ChiLan1.0
BOK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,264,085 - 144,279,627 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,278,982 - 144,294,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,832,458 - 128,847,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,626,494 - 247,640,238 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,626,494 - 247,640,238 (+)Ensemblpanpan1.1panPan2
BOK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,449,700 - 51,450,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,662,160 - 51,671,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,642,280 - 51,651,918 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,641,083 - 51,651,905 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,491,666 - 51,501,244 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,231,578 - 51,241,142 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,507,856 - 51,517,459 (+)NCBIUU_Cfam_GSD_1.0
Bok
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,866,849 - 192,874,583 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745345,635 - 351,749 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745344,837 - 350,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BOK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,171,143 - 140,184,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,171,134 - 140,184,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BOK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,621,936 - 127,634,091 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,622,149 - 127,635,833 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,688,317 - 71,701,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bok
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,564,979 - 5,573,459 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,564,671 - 5,573,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bok
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:509
Count of miRNA genes:224
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000024526, ENSRNOT00000024695
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat

Markers in Region
RH133492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2994,234,285 - 94,234,443 (+)MAPPERmRatBN7.2
Rnor_6.09100,840,308 - 100,840,465NCBIRnor6.0
Rnor_5.09100,493,373 - 100,493,530UniSTSRnor5.0
RGSC_v3.4992,980,784 - 92,980,941UniSTSRGSC3.4
Celera991,768,770 - 91,768,927UniSTS
RH 3.4 Map9808.0UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024526   ⟹   ENSRNOP00000024526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,223,428 - 94,234,472 (+)Ensembl
Rnor_6.0 Ensembl9100,830,250 - 100,839,877 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000024695   ⟹   ENSRNOP00000024693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,223,389 - 94,234,476 (+)Ensembl
Rnor_6.0 Ensembl9100,829,552 - 100,840,504 (+)Ensembl
RefSeq Acc Id: NM_017312   ⟹   NP_059008
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,670,929 - 101,681,834 (+)NCBI
mRatBN7.2994,223,571 - 94,234,476 (+)NCBI
Rnor_6.09100,829,593 - 100,840,498 (+)NCBI
Rnor_5.09100,482,657 - 100,493,563 (+)NCBI
RGSC_v3.4992,970,069 - 92,980,974 (+)RGD
Celera991,758,055 - 91,768,960 (+)RGD
Sequence:
RefSeq Acc Id: XM_039083130   ⟹   XP_038939058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,670,729 - 101,681,834 (+)NCBI
mRatBN7.2994,223,493 - 94,234,476 (+)NCBI
RefSeq Acc Id: NP_059008   ⟸   NM_017312
- UniProtKB: O88857 (UniProtKB/Swiss-Prot),   Q792S6 (UniProtKB/Swiss-Prot),   A6JR24 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024693   ⟸   ENSRNOT00000024695
Ensembl Acc Id: ENSRNOP00000024526   ⟸   ENSRNOT00000024526
RefSeq Acc Id: XP_038939058   ⟸   XM_039083130
- Peptide Label: isoform X1
- UniProtKB: A6JR25 (UniProtKB/TrEMBL)
Protein Domains
Bcl-2 Bcl-2 homology region 1-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q792S6-F1-model_v2 AlphaFold Q792S6 1-213 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696879
Promoter ID:EPDNEW_R7404
Type:multiple initiation site
Name:Bok_1
Description:BOK, BCL2 family apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,829,585 - 100,829,645EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70984 AgrOrtholog
BioCyc Gene G2FUF-26633 BioCyc
Ensembl Genes ENSRNOG00000018214 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055010325 UniProtKB/Swiss-Prot
  ENSRNOG00060009462 UniProtKB/Swiss-Prot
  ENSRNOG00065020467 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024526.5 UniProtKB/Swiss-Prot
  ENSRNOT00000024695.7 UniProtKB/Swiss-Prot
  ENSRNOT00055017469 UniProtKB/Swiss-Prot
  ENSRNOT00060015981 UniProtKB/Swiss-Prot
  ENSRNOT00065034603 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132448 IMAGE-MGC_LOAD
InterPro Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
KEGG Report rno:29884 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93540 IMAGE-MGC_LOAD
NCBI Gene 29884 ENTREZGENE
PANTHER BCL-2 RELATED UniProtKB/TrEMBL
  BCL-2-RELATED OVARIAN KILLER PROTEIN UniProtKB/TrEMBL
  PTHR11256 UniProtKB/Swiss-Prot
  PTHR11256:SF48 UniProtKB/Swiss-Prot
Pfam Bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bok PhenoGen
PRINTS BCL2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018214 RatGTEx
  ENSRNOG00055010325 RatGTEx
  ENSRNOG00060009462 RatGTEx
  ENSRNOG00065020467 RatGTEx
SMART BCL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Bcl-2 inhibitors of programmed cell death UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JR24 ENTREZGENE, UniProtKB/TrEMBL
  A6JR25 ENTREZGENE, UniProtKB/TrEMBL
  A6JR26_RAT UniProtKB/TrEMBL
  BOK_RAT UniProtKB/Swiss-Prot
  O88857 ENTREZGENE
  Q792S6 ENTREZGENE
UniProt Secondary O88857 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-27 Bok  BCL2 family apoptosis regulator BOK  Bok  BOK, BCL2 family apoptosis regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-22 Bok  BOK, BCL2 family apoptosis regulator  Bok  BCL2-related ovarian killer  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Bok  BCL2-related ovarian killer  Bok  Bcl-2-related ovarian killer protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Bok  Bcl-2-related ovarian killer protein      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains Bcl-2 homology (BH) domains 1, 2, and 3 and a C-terminal transmembrane region present in other Bcl-2 proteins, but lacks the BH4 domain found only in anti-apoptotic Bcl-2 proteins 70678
gene_expression highly expressed in ovary, testis, and uterus 70678
gene_physical_interaction heterodimerizes strongly with Mcl-1, BHRF1, and Bfl-1 but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members 70678