Msra (methionine sulfoxide reductase A) - Rat Genome Database

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Gene: Msra (methionine sulfoxide reductase A) Rattus norvegicus
Analyze
Symbol: Msra
Name: methionine sulfoxide reductase A
RGD ID: 70979
Description: Enables peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human MSRA (methionine sulfoxide reductase A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93315; mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; PMSR; protein-methionine-S-oxide reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Msraem3Mcwi ; Msraem4Mcwi
Genetic Models: SS-Msraem4Mcwi ; SS-Msraem3Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,514,818 - 42,853,278 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,527,045 - 42,853,279 (-)EnsemblGRCr8
mRatBN7.21538,363,459 - 38,677,406 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,351,445 - 38,676,585 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1540,220,249 - 40,540,125 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01541,370,932 - 41,690,814 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,824,072 - 40,137,073 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01547,488,333 - 47,800,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,488,894 - 47,800,024 (-)Ensemblrn6Rnor6.0
Rnor_5.01551,307,920 - 51,550,758 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41543,509,775 - 43,756,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1538,127,708 - 38,353,451 (-)NCBICelera
RGSC_v3.11543,543,986 - 43,771,983 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
cerium trichloride  (ISO)
chloramine T  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
DDT  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
elemental carbon  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
herbicide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
picloram  (ISO)
propanal  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
S-methylcysteine  (ISO)
salvianolic acid B  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (ISO)
mitochondrial matrix  (IDA,IEA,ISO)
mitochondrion  (IDA,IEA,ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Iron, ferritin and proteins of the methionine-centered redox cycle in young and old rat hearts. Bulvik B, etal., Mech Ageing Dev. 2009 Mar;130(3):139-44. Epub 2008 Oct 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Identification of a new functional splice variant of the enzyme methionine sulphoxide reductase A (MSRA) expressed in rat vascular smooth muscle cells. Haenold R, etal., Free Radic Res. 2007 Nov;41(11):1233-45.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging. Petropoulos I, etal., Biochem J 2001 May 1;355(Pt 3):819-25.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells. Vougier S, etal., Biochem J. 2003 Jul 15;373(Pt 2):531-7. doi: 10.1042/BJ20030443.
Additional References at PubMed
PMID:11606777   PMID:12477932   PMID:14745014   PMID:15489334   PMID:18083115   PMID:18614015   PMID:19056867   PMID:19085252   PMID:19646993   PMID:20368336   PMID:21726174   PMID:23036869  
PMID:23376485   PMID:24120970   PMID:24315642   PMID:25602783   PMID:30717164  


Genomics

Comparative Map Data
Msra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,514,818 - 42,853,278 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,527,045 - 42,853,279 (-)EnsemblGRCr8
mRatBN7.21538,363,459 - 38,677,406 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,351,445 - 38,676,585 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1540,220,249 - 40,540,125 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01541,370,932 - 41,690,814 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,824,072 - 40,137,073 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01547,488,333 - 47,800,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,488,894 - 47,800,024 (-)Ensemblrn6Rnor6.0
Rnor_5.01551,307,920 - 51,550,758 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41543,509,775 - 43,756,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1538,127,708 - 38,353,451 (-)NCBICelera
RGSC_v3.11543,543,986 - 43,771,983 (-)NCBI
Cytogenetic Map15p12NCBI
MSRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38810,054,292 - 10,428,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl810,054,278 - 10,428,897 (+)Ensemblhg38GRCh38
GRCh3789,911,802 - 10,286,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3689,949,236 - 10,323,805 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3489,949,235 - 10,323,803NCBI
Celera89,038,143 - 9,413,201 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef88,840,844 - 9,216,822 (+)NCBIHuRef
CHM1_189,977,395 - 10,352,199 (+)NCBICHM1_1
T2T-CHM13v2.089,310,290 - 9,686,356 (-)NCBIT2T-CHM13v2.0
Msra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391464,360,070 - 64,693,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1464,360,074 - 64,693,352 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381464,122,621 - 64,455,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1464,122,625 - 64,455,903 (-)Ensemblmm10GRCm38
MGSCv371464,741,462 - 65,074,740 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361463,076,735 - 63,410,013 (-)NCBIMGSCv36mm8
Celera1461,900,138 - 62,232,246 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.36NCBI
Msra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540351,730,156 - 52,071,269 (+)Ensembl
ChiLan1.0NW_00495540351,729,753 - 52,071,269 (+)NCBIChiLan1.0ChiLan1.0
MSRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2726,500,353 - 26,924,492 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan182,532,861 - 2,953,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v088,751,846 - 9,163,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MSRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12527,608,987 - 28,043,461 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2527,609,349 - 28,043,271 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2528,256,191 - 28,688,850 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02527,767,761 - 28,194,963 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2527,766,608 - 28,194,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12527,722,315 - 28,155,074 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02527,616,218 - 28,042,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02527,771,061 - 28,204,784 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Msra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049436,154,114 - 6,480,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366752,106,116 - 2,434,460 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366752,104,618 - 2,432,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1413,335,420 - 13,768,423 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11413,334,731 - 13,718,914 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21414,869,083 - 15,060,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.188,664,040 - 9,026,632 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl88,663,034 - 8,993,433 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605233,390,875 - 33,760,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msra
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11259,969,337 - 60,292,275 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Msra
1112 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:91
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000016616, ENSRNOT00000071197, ENSRNOT00000072997
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
D15Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81542,844,150 - 42,844,318 (+)Marker Load Pipeline
mRatBN7.21538,668,278 - 38,668,448 (+)MAPPERmRatBN7.2
Rnor_6.01547,791,819 - 47,791,986NCBIRnor6.0
Rnor_5.01551,542,543 - 51,542,710UniSTSRnor5.0
RGSC_v3.41543,748,068 - 43,748,235UniSTSRGSC3.4
RGSC_v3.41543,748,067 - 43,748,235RGDRGSC3.4
Celera1538,345,236 - 38,345,403UniSTS
RGSC_v3.11543,763,768 - 43,763,935RGD
RH 3.4 Map15289.9RGD
RH 3.4 Map15289.9UniSTS
RH 2.0 Map15261.3RGD
Cytogenetic Map15p12UniSTS
D15Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21538,536,732 - 38,536,957 (+)MAPPERmRatBN7.2
Rnor_6.01547,660,913 - 47,661,137NCBIRnor6.0
Rnor_5.01551,412,733 - 51,412,957UniSTSRnor5.0
RGSC_v3.41543,615,579 - 43,615,804RGDRGSC3.4
RGSC_v3.41543,615,580 - 43,615,804UniSTSRGSC3.4
Celera1538,214,714 - 38,214,938UniSTS
RGSC_v3.11543,631,279 - 43,631,504RGD
RH 2.0 Map15261.4RGD
Cytogenetic Map15p12UniSTS
D15Got227  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81542,821,721 - 42,821,935 (+)Marker Load Pipeline
mRatBN7.21538,645,845 - 38,646,060 (+)MAPPERmRatBN7.2
Rnor_6.01547,770,514 - 47,770,728NCBIRnor6.0
Rnor_5.01551,521,238 - 51,521,452UniSTSRnor5.0
RGSC_v3.41543,725,663 - 43,725,877UniSTSRGSC3.4
Celera1538,323,317 - 38,323,531UniSTS
Cytogenetic Map15p12UniSTS
RH137586  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15p12UniSTS
AU048707  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21538,615,789 - 38,615,967 (+)MAPPERmRatBN7.2
Rnor_6.01547,740,442 - 47,740,619NCBIRnor6.0
Rnor_5.01551,491,166 - 51,491,343UniSTSRnor5.0
RGSC_v3.41543,695,214 - 43,695,391UniSTSRGSC3.4
Celera1538,293,281 - 38,293,462UniSTS
Cytogenetic Map15p12UniSTS
AU049139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21538,656,746 - 38,656,893 (+)MAPPERmRatBN7.2
Rnor_6.01547,781,415 - 47,781,561NCBIRnor6.0
Rnor_5.01551,532,139 - 51,532,285UniSTSRnor5.0
RGSC_v3.41543,736,565 - 43,736,711UniSTSRGSC3.4
Cytogenetic Map15p12UniSTS


Genetic Models
This gene Msra is modified in the following models/strains:
SS-Msraem4Mcwi     SS-Msraem3Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016616   ⟹   ENSRNOP00000016616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,527,045 - 42,852,366 (-)Ensembl
mRatBN7.2 Ensembl1538,351,445 - 38,676,555 (-)Ensembl
Rnor_6.0 Ensembl1547,488,928 - 47,800,024 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072997   ⟹   ENSRNOP00000067242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,539,363 - 42,852,356 (-)Ensembl
mRatBN7.2 Ensembl1538,363,463 - 38,676,486 (-)Ensembl
Rnor_6.0 Ensembl1547,488,894 - 47,800,024 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095387   ⟹   ENSRNOP00000096051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,539,363 - 42,827,256 (-)Ensembl
mRatBN7.2 Ensembl1538,363,463 - 38,651,182 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101265   ⟹   ENSRNOP00000084705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,539,363 - 42,852,356 (-)Ensembl
mRatBN7.2 Ensembl1538,363,461 - 38,676,486 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102126   ⟹   ENSRNOP00000097940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,539,363 - 42,853,279 (-)Ensembl
mRatBN7.2 Ensembl1538,363,463 - 38,676,585 (-)Ensembl
RefSeq Acc Id: NM_053307   ⟹   NP_445759
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,539,360 - 42,852,366 (-)NCBI
mRatBN7.21538,363,462 - 38,676,496 (-)NCBI
Rnor_6.01547,488,333 - 47,800,034 (-)NCBI
Rnor_5.01551,307,920 - 51,550,758 (-)NCBI
RGSC_v3.41543,509,775 - 43,756,283 (-)RGD
Celera1538,127,708 - 38,353,451 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093214   ⟹   XP_038949142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,539,357 - 42,853,278 (-)NCBI
mRatBN7.21538,363,462 - 38,677,406 (-)NCBI
RefSeq Acc Id: XM_039093215   ⟹   XP_038949143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,539,357 - 42,746,522 (-)NCBI
mRatBN7.21538,363,459 - 38,570,644 (-)NCBI
RefSeq Acc Id: XM_039093216   ⟹   XP_038949144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,539,357 - 42,827,100 (-)NCBI
mRatBN7.21538,363,459 - 38,651,197 (-)NCBI
RefSeq Acc Id: XM_039093218   ⟹   XP_038949146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,539,357 - 42,801,014 (-)NCBI
mRatBN7.21538,363,459 - 38,625,131 (-)NCBI
RefSeq Acc Id: XM_063274183   ⟹   XP_063130253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,539,357 - 42,827,327 (-)NCBI
RefSeq Acc Id: XR_010057810
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,514,818 - 42,852,402 (-)NCBI
RefSeq Acc Id: NP_445759   ⟸   NM_053307
- UniProtKB: A9LAT3 (UniProtKB/Swiss-Prot),   A9LAT4 (UniProtKB/Swiss-Prot),   Q923M1 (UniProtKB/Swiss-Prot),   A0A8I6A0P8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067242   ⟸   ENSRNOT00000072997
Ensembl Acc Id: ENSRNOP00000016616   ⟸   ENSRNOT00000016616
RefSeq Acc Id: XP_038949144   ⟸   XM_039093216
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AN14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949146   ⟸   XM_039093218
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949143   ⟸   XM_039093215
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949142   ⟸   XM_039093214
- Peptide Label: isoform X1
- UniProtKB: Q923M1 (UniProtKB/Swiss-Prot),   A9LAT3 (UniProtKB/Swiss-Prot),   A9LAT4 (UniProtKB/Swiss-Prot),   A0A8I6A0P8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096051   ⟸   ENSRNOT00000095387
Ensembl Acc Id: ENSRNOP00000097940   ⟸   ENSRNOT00000102126
Ensembl Acc Id: ENSRNOP00000084705   ⟸   ENSRNOT00000101265
RefSeq Acc Id: XP_063130253   ⟸   XM_063274183
- Peptide Label: isoform X4
Protein Domains
Peptide methionine sulphoxide reductase MsrA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923M1-F1-model_v2 AlphaFold Q923M1 1-233 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699784
Promoter ID:EPDNEW_R10308
Type:initiation region
Name:Msra_1
Description:methionine sulfoxide reductase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,800,066 - 47,800,126EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70979 AgrOrtholog
BioCyc Gene G2FUF-13386 BioCyc
Ensembl Genes ENSRNOG00000012440 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072997 ENTREZGENE
  ENSRNOT00000095387 ENTREZGENE
  ENSRNOT00000102126 ENTREZGENE
  ENSRNOT00000102126.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1060.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107102 IMAGE-MGC_LOAD
InterPro Met_Sox_Rdtase_MsrA UniProtKB/Swiss-Prot
  Met_Sox_Rdtase_MsrA_sf UniProtKB/Swiss-Prot
  MsrA_MetSO_reductase UniProtKB/Swiss-Prot
KEGG Report rno:29447 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93315 IMAGE-MGC_LOAD
NCBI Gene 29447 ENTREZGENE
PANTHER MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE UniProtKB/Swiss-Prot
  MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE UniProtKB/Swiss-Prot
Pfam PMSR UniProtKB/Swiss-Prot
PhenoGen Msra PhenoGen
RatGTEx ENSRNOG00000012440 RatGTEx
Superfamily-SCOP SSF55068 UniProtKB/Swiss-Prot
UniProt A0A8I6A0P8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN14 ENTREZGENE, UniProtKB/TrEMBL
  A6K6H7_RAT UniProtKB/TrEMBL
  A9LAT3 ENTREZGENE
  A9LAT4 ENTREZGENE
  F1LSJ6_RAT UniProtKB/TrEMBL
  M0RCC8_RAT UniProtKB/TrEMBL
  MSRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A9LAT3 UniProtKB/Swiss-Prot
  A9LAT4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Msra  methionine sulfoxide reductase A      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression may decrease with age 70794