Dusp6 (dual specificity phosphatase 6) - Rat Genome Database

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Gene: Dusp6 (dual specificity phosphatase 6) Rattus norvegicus
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Symbol: Dusp6
Name: dual specificity phosphatase 6
RGD ID: 70978
Description: Enables protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; response to growth factor; and response to xenobiotic stimulus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of brain ischemia and pancreatitis. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity protein phosphatase 6; MAP kinase phosphatase 3; MGC93276; mitogen-activated protein kinase phosphatase 3; MKP-3; Mkp3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8735,979,502 - 35,983,834 (+)NCBIGRCr8
mRatBN7.2734,092,848 - 34,097,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl734,092,943 - 34,097,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx736,079,912 - 36,084,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0738,261,675 - 38,265,912 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0737,995,062 - 37,999,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0741,475,163 - 41,479,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl741,475,163 - 41,479,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0741,506,397 - 41,510,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4736,893,264 - 36,897,494 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1736,913,534 - 36,917,764 (+)NCBI
Celera731,106,671 - 31,110,901 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
Dusp6Ratbrain ischemia  IEP 2316092mRNA:increased expression:brainRGD 
Dusp6Ratbreast cancer  ISODUSP6 (Homo sapiens)7495809protein:increased expression:mammary glandRGD 
Dusp6RatExperimental Seizures  IEP 728656 RGD 
Dusp6RatExperimental Seizures  IEP 2316089mRNA:increased expression:brainRGD 
Dusp6RatHyperalgesia treatmentIEP 7771531associated with Sciatic NeuropathyRGD 
Dusp6Ratleishmaniasis treatmentISODusp6 (Mus musculus)7771536 RGD 
Dusp6Ratpancreatitis  IEP 2301725mRNA:increased expression:pancreasRGD 
Dusp6RatPostoperative Pain  ISODusp6 (Mus musculus)7771585associated with InflammationRGD 
Object Symbol
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Original Reference(s)
Dusp6Rathypogonadotropic hypogonadism 19 with or without anosmia  ISODUSP6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23643382 more ...
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Original Reference(s)
Dusp6RatAnimal Mammary Neoplasms  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Dusp6Ratcarcinoma  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Dusp6RatExperimental Liver Cirrhosis  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Dusp6RatExperimental Mammary Neoplasms  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Dusp6Ratglioblastoma  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21499306
Dusp6Rathypogonadotropic hypogonadism 7 with or without anosmia  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Dusp6RatMyocardial Ischemia  ISODUSP6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
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Original Reference(s)
Dusp6Rathypogonadotropic hypogonadism 19 with or without anosmia  ISODUSP6 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Dusp6Rat(-)-alpha-phellandrene increases expressionISODUSP6 (Homo sapiens)6480464alpha phellandrene results in increased expression of DUSP6 mRNACTDPMID:25075043
Dusp6Rat(-)-anisomycin decreases expressionISODUSP6 (Homo sapiens)6480464Anisomycin results in decreased expression of DUSP6 mRNACTDPMID:24247028
Dusp6Rat(-)-demecolcine increases expressionISODUSP6 (Homo sapiens)6480464Demecolcine results in increased expression of DUSP6 mRNACTDPMID:23649840
Dusp6Rat(-)-epigallocatechin 3-gallate multiple interactionsISODUSP6 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP6 mRNACTDPMID:22079256
Dusp6Rat(S)-nicotine increases expressionISODusp6 (Mus musculus)6480464Nicotine results in increased expression of DUSP6 mRNACTDPMID:17456735 and PMID:21955143
Dusp6Rat1,2-dimethylhydrazine multiple interactionsISODusp6 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DUSP6 mRNACTDPMID:22206623
Dusp6Rat1,3-dinitrobenzene increases expressionEXP 64804643-dinitrobenzene results in increased expression of DUSP6 mRNACTDPMID:21983209
Dusp6Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of DUSP6 mRNACTDPMID:25380136 and PMID:30723492
Dusp6Rat1-nitropyrene increases expressionISODUSP6 (Homo sapiens)64804641-nitropyrene results in increased expression of DUSP6 mRNACTDPMID:19041380
Dusp6Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of DUSP6 mRNACTDPMID:16079270
Dusp6Rat17beta-estradiol multiple interactionsISODUSP6 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of DUSP6 mRNA more ...CTDPMID:19619570 more ...
Dusp6Rat17beta-estradiol decreases expressionISODusp6 (Mus musculus)6480464Estradiol results in decreased expression of DUSP6 mRNACTDPMID:39298647
Dusp6Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of DUSP6 mRNACTDPMID:32145629
Dusp6Rat17beta-estradiol increases expressionISODUSP6 (Homo sapiens)6480464Estradiol results in increased expression of DUSP6 mRNACTDPMID:19619570 more ...
Dusp6Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:16984957
Dusp6Rat2,2',4,4',5,5'-hexachlorobiphenyl increases expressionISODUSP6 (Homo sapiens)64804642 more ...CTDPMID:38568856
Dusp6Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODUSP6 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP6 mRNACTDPMID:19619570
Dusp6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DUSP6 mRNACTDPMID:34747641
Dusp6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISODUSP6 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of DUSP6 mRNACTDPMID:19619570 more ...
Dusp6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODusp6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DUSP6 mRNACTDPMID:21570461

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Biological Process
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Original Reference(s)
Dusp6Ratcell differentiation  IEP 70726 RGD 
Dusp6Ratnegative regulation of ERK1 and ERK2 cascade  IDA 728656 RGD 
Dusp6Ratnegative regulation of ERK1 and ERK2 cascade involved_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratnegative regulation of ERK1 and ERK2 cascade involved_inIBAFB:FBgn0036844 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6Ratnegative regulation of ERK1 and ERK2 cascade involved_inISODUSP6 (Homo sapiens)1624291 PMID:18771677RGDPMID:18771677
Dusp6Ratnegative regulation of MAPK cascade involved_inISODUSP6 (Homo sapiens)1624291 PMID:8670865RGDPMID:8670865
Dusp6Ratnegative regulation of MAPK cascade involved_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratnegative regulation of protein phosphorylation acts_upstream_of_or_withinISODusp6 (Mus musculus)1624291MGI:3827011 PMID:18753132RGDPMID:18753132
Dusp6Ratpeptidyl-tyrosine dephosphorylation involved_inISODUSP6 (Homo sapiens)1624291 PMID:8670865RGDPMID:8670865
Dusp6Ratpositive regulation of apoptotic process involved_inISODUSP6 (Homo sapiens)1624291 PMID:10846176RGDPMID:10846176
Dusp6Ratpositive regulation of apoptotic process involved_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratpositive regulation of apoptotic process involved_inIBAPANTHER:PTN002562926 and UniProtKB:Q168281600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6Ratpositive regulation of cellular process  IMP 7771586oligodendrocyte deathRGD 
Dusp6Ratprotein dephosphorylation acts_upstream_of_or_withinISODusp6 (Mus musculus)1624291MGI:3827011 PMID:15284227 and PMID:18753132RGDPMID:15284227 and PMID:18753132
Dusp6Ratregulation of heart growth involved_inIBAMGI:1914853 and PANTHER:PTN0025629261600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6Ratregulation of heart growth acts_upstream_of_or_withinIEAUniProtKB:Q9DBB1 and ensembl:ENSMUSP000000201181600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratregulation of heart growth acts_upstream_of_or_withinISODusp6 (Mus musculus)1624291MGI:3827011 PMID:18753132RGDPMID:18753132
Dusp6Ratresponse to growth factor  IEP 2316093 RGD 
Dusp6Ratresponse to nitrosative stress involved_inISODUSP6 (Homo sapiens)1624291 PMID:10846176RGDPMID:10846176
Dusp6Ratresponse to nitrosative stress involved_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Dusp6Ratcytoplasm is_active_inIBAFB:FBgn0036844 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6Ratcytoplasm located_inISODUSP6 (Homo sapiens)1624291 PMID:8670865 and PMID:9788880RGDPMID:8670865 and PMID:9788880
Dusp6Ratcytoplasm located_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Dusp6Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Dusp6Ratcytosol located_inISODUSP6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Dusp6Ratcytosol located_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratcytosol is_active_inIBAFB:FBgn0036844 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6Ratnucleoplasm located_inIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratnucleoplasm located_inISODUSP6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
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Molecular Function
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Original Reference(s)
Dusp6Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Dusp6RatMAP kinase tyrosine phosphatase activity enablesIBAFB:FBgn0036844 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesISODUSP6 (Homo sapiens)1624291 PMID:8670865RGDPMID:8670865
Dusp6RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesIEAUniProtKB:Q16828 and ensembl:ENSP000002794881600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesIEAInterPro:IPR0083431600115GO_REF:0000002InterProGO_REF:0000002
Dusp6RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesIBACGD:CAL0000191382 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp6Ratphosphatase activity enablesIEAARBA:ARBA000263931600115GO_REF:0000117UniProtGO_REF:0000117
Dusp6Ratphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Dusp6Ratphosphoprotein phosphatase activity enablesISODusp6 (Mus musculus)1624291 PMID:15284227RGDPMID:15284227
Dusp6Ratphosphoprotein phosphatase activity enablesIEAUniProtKB:Q9DBB1 and ensembl:ENSMUSP000000201181600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp6Ratprotein binding enablesISODUSP6 (Homo sapiens)1624291UniProtKB:P05067 more ...RGDPMID:12840032 more ...
Dusp6Ratprotein binding enablesISODusp6 (Mus musculus)1624291PR:P60202 more ...RGDPMID:15284227 and PMID:16148006
Dusp6Ratprotein serine/threonine phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
Dusp6Ratprotein serine/threonine phosphatase activity enablesIEARHEA:20629 and RHEA:470041600115GO_REF:0000116RHEAGO_REF:0000116
Dusp6Ratprotein tyrosine phosphatase activity enablesIEAEC:3.1.3.481600115GO_REF:0000003UniProtGO_REF:0000003
Dusp6Ratprotein tyrosine phosphatase activity enablesIEARHEA:106841600115GO_REF:0000116RHEAGO_REF:0000116
Dusp6Ratprotein tyrosine/serine/threonine phosphatase activity  IDA 70726 RGD 
Dusp6Ratprotein tyrosine/threonine phosphatase activity enablesIBAPANTHER:PTN002562845 and UniProtKB:Q9Y6W61600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  
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Original Reference(s)
Dusp6Ratthe extracellular signal-regulated Raf/Mek/Erk signaling pathway   ISODUSP6 (Homo sapiens)2293881 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Dusp6Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010

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#
Reference Title
Reference Citation
1. Irinotecan changes gene expression in the small intestine of the rat with breast cancer. Bowen JM, etal., Cancer Chemother Pharmacol. 2007 Feb;59(3):337-48. Epub 2006 Jun 24.
2. Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12. Camps M, etal., FEBS Lett. 1998 Mar 27;425(2):271-6.
3. Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death. Domercq M, etal., J Biol Chem. 2011 Apr 1;286(13):11825-36. doi: 10.1074/jbc.M110.153049. Epub 2011 Feb 7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
7. Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types. Johnson KJ, etal., Biol Reprod. 2007 Dec;77(6):978-89. Epub 2007 Sep 19.
8. Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rat brain. Kodama M, etal., Neuropsychopharmacology. 2005 Feb;30(2):360-71.
9. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
10. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. Landry RP, etal., J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.
11. Gene Data Set MGD Curation, June 12, 2002
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. Mourey RJ, etal., J Biol Chem 1996 Feb 16;271(7):3795-802.
14. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Changes in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesis. Pacitto SR, etal., J Immunotoxicol. 2007 Oct;4(4):253-66.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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PMID:8670865   PMID:9535927   PMID:9788880   PMID:10846176   PMID:12477932   PMID:15284227   PMID:15489334   PMID:17046812   PMID:18753132   PMID:18771677   PMID:23337371   PMID:24861519  
PMID:26435497   PMID:27422819   PMID:30816666   PMID:34676875   PMID:34944046   PMID:35630630   PMID:36335128  



Dusp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8735,979,502 - 35,983,834 (+)NCBIGRCr8
mRatBN7.2734,092,848 - 34,097,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl734,092,943 - 34,097,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx736,079,912 - 36,084,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0738,261,675 - 38,265,912 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0737,995,062 - 37,999,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0741,475,163 - 41,479,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl741,475,163 - 41,479,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0741,506,397 - 41,510,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4736,893,264 - 36,897,494 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1736,913,534 - 36,917,764 (+)NCBI
Celera731,106,671 - 31,110,901 (+)NCBICelera
Cytogenetic Map7q13NCBI
DUSP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381289,347,235 - 89,352,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1289,347,235 - 89,352,501 (-)EnsemblGRCh38hg38GRCh38
GRCh371289,741,012 - 89,746,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361288,265,968 - 88,270,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 341288,244,306 - 88,248,764NCBI
Celera1289,413,532 - 89,417,991 (-)NCBICelera
Cytogenetic Map12q21.33NCBI
HuRef1286,807,701 - 86,812,160 (-)NCBIHuRef
CHM1_11289,706,790 - 89,711,249 (-)NCBICHM1_1
T2T-CHM13v2.01289,329,179 - 89,334,445 (-)NCBIT2T-CHM13v2.0
Dusp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391099,098,676 - 99,103,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1099,099,093 - 99,103,351 (+)EnsemblGRCm39 Ensembl
GRCm381099,263,231 - 99,267,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1099,263,231 - 99,267,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv371098,725,865 - 98,730,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361098,692,919 - 98,697,172 (+)NCBIMGSCv36mm8
Celera10101,235,116 - 101,239,374 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1051.13NCBI
Dusp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540526,662,018 - 26,666,314 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540526,662,018 - 26,666,314 (-)NCBIChiLan1.0ChiLan1.0
DUSP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21097,374,395 - 97,379,496 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11297,370,793 - 97,375,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01286,875,289 - 86,879,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11290,195,482 - 90,200,321 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1290,195,482 - 90,200,321 (-)Ensemblpanpan1.1panPan2
DUSP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11530,322,472 - 30,327,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1530,323,697 - 30,326,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1530,777,953 - 30,782,527 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01530,967,877 - 30,972,449 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1530,968,620 - 30,972,415 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11530,272,051 - 30,276,623 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01530,333,920 - 30,338,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01530,628,124 - 30,632,696 (-)NCBIUU_Cfam_GSD_1.0
Dusp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494529,921,860 - 29,926,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365076,308,886 - 6,313,935 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365076,309,114 - 6,314,512 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl593,302,975 - 93,307,504 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1593,303,058 - 93,307,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DUSP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11184,741,957 - 84,747,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1184,741,444 - 84,745,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037160,455,940 - 160,460,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475017,362,515 - 17,367,739 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475017,361,725 - 17,366,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dusp6
14 total Variants

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:196
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000037844
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat

1 to 10 of 30 rows
RH133891  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2734,096,224 - 34,096,428 (+)MAPPERmRatBN7.2
Rnor_6.0741,478,432 - 41,478,635NCBIRnor6.0
Rnor_5.0741,509,666 - 41,509,869UniSTSRnor5.0
RGSC_v3.4736,896,533 - 36,896,736UniSTSRGSC3.4
Celera731,109,940 - 31,110,143UniSTS
RH 3.4 Map7279.6UniSTS
Cytogenetic Map7q13UniSTS
WI-14395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2734,094,672 - 34,095,830 (+)MAPPERmRatBN7.2
Rnor_6.0741,476,880 - 41,478,037NCBIRnor6.0
Rnor_5.0741,508,114 - 41,509,271UniSTSRnor5.0
RGSC_v3.4736,894,981 - 36,896,138UniSTSRGSC3.4
Celera731,108,388 - 31,109,545UniSTS
Cytogenetic Map7q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000037844   ⟹   ENSRNOP00000032969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl734,092,943 - 34,097,185 (+)Ensembl
Rnor_6.0 Ensembl741,475,163 - 41,479,392 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111909   ⟹   ENSRNOP00000087245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl734,093,076 - 34,097,181 (+)Ensembl
RefSeq Acc Id: NM_053883   ⟹   NP_446335
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8735,979,604 - 35,983,834 (+)NCBI
mRatBN7.2734,092,956 - 34,097,186 (+)NCBI
Rnor_6.0741,475,163 - 41,479,393 (+)NCBI
Rnor_5.0741,506,397 - 41,510,627 (+)NCBI
RGSC_v3.4736,893,264 - 36,897,494 (+)RGD
Celera731,106,671 - 31,110,901 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078252   ⟹   XP_038934180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8735,979,502 - 35,983,830 (+)NCBI
mRatBN7.2734,092,848 - 34,097,183 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_446335 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934180 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB06202 (Get FASTA)   NCBI Sequence Viewer  
  AAH87003 (Get FASTA)   NCBI Sequence Viewer  
  CAA63895 (Get FASTA)   NCBI Sequence Viewer  
  EDM16816 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032969
  ENSRNOP00000032969.4
  ENSRNOP00000087245
  ENSRNOP00000087245.1
GenBank Protein Q64346 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_446335   ⟸   NM_053883
- UniProtKB: Q64346 (UniProtKB/Swiss-Prot),   A6IG82 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032969   ⟸   ENSRNOT00000037844
RefSeq Acc Id: XP_038934180   ⟸   XM_039078252
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QHD1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087245   ⟸   ENSRNOT00000111909
Name Modeler Protein Id AA Range Protein Structure
AF-Q64346-F1-model_v2 AlphaFold Q64346 1-381 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695174
Promoter ID:EPDNEW_R5699
Type:multiple initiation site
Name:Dusp6_1
Description:dual specificity phosphatase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0741,475,150 - 41,475,210EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34271 BioCyc
Ensembl Genes ENSRNOG00000023896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037844 ENTREZGENE
  ENSRNOT00000037844.4 UniProtKB/TrEMBL
  ENSRNOT00000111909 ENTREZGENE
  ENSRNOT00000111909.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124105 IMAGE-MGC_LOAD
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116663 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93276 IMAGE-MGC_LOAD
NCBI Gene 116663 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp6 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023896 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QHD1 ENTREZGENE, UniProtKB/TrEMBL
  A6IG82 ENTREZGENE, UniProtKB/TrEMBL
  DUS6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dusp6  dual specificity phosphatase 6      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_cellular_localization localized to cytoplasm 70726