DUSP6 (dual specificity phosphatase 6)

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Keyword

Gene: DUSP6 (dual specificity phosphatase 6) Homo sapiens

Symbol:

DUSP6

Name:

dual specificity phosphatase 6

Description:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

dual specificity protein phosphatase 6; dual specificity protein phosphatase PYST1; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; MKP3; OTTHUMP00000242453; OTTHUMP00000242454; PYST1; serine/threonine specific protein phosphatase

Orthologs:

Mus musculus : Dusp6 (dual specificity phosphatase 6) MGI
Rattus norvegicus : Dusp6 (dual specificity phosphatase 6)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	12	89,589,555 - 89,594,014	-	NCBI
Human Genome Assembly HuRef	12	86,807,701 - 86,812,160	-	NCBI
Human Genome Assembly GRCh37	12	89,741,837 - 89,746,296	-	NCBI
Human Genome Assembly Build 36	12	88,265,968 - 88,270,427	-	NCBI
Human Cytogenetic Map	12	q22-q23		NCBI
Human Genome Assembly	12	88,244,306 - 88,248,764		NCBI