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Gene: Ftcd (formimidoyltransferase cyclodeaminase) Rattus norvegicus

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Symbol:

Ftcd

Name:

formimidoyltransferase cyclodeaminase

RGD ID:

70915

Description:

Enables formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; and microtubule binding activity. Involved in cytoskeleton organization. Located in Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; histidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-benzylpiperazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

58 kDa microtubule-binding protein; formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FTCD (formimidoyltransferase cyclodeaminase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ftcd (formiminotransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ftcd (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FTCD (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FTCD (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ftcd (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FTCD (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FTCD (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ftcd (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ftcd (formimidoyltransferase cyclodeaminase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FTCD (formimidoyltransferase cyclodeaminase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ftcd (formiminotransferase cyclodeaminase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ftcd (formimidoyltransferase cyclodeaminase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ftcd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ftcd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,054,710 - 12,068,219 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	12,054,711 - 12,068,237 (-)	Ensembl				GRCr8
mRatBN7.2	20	12,055,203 - 12,068,717 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,055,208 - 12,068,735 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	12,751,494 - 12,765,024 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,112,414 - 12,125,946 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,584,199 - 12,597,724 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	12,806,957 - 12,820,466 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	12,806,957 - 12,820,466 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	14,965,126 - 14,978,635 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	12,470,291 - 12,483,807 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	13,553,681 - 13,567,051 (-)	NCBI		Celera
RGSC_v3.1	20	12,470,516 - 12,484,034 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Burkitt lymphoma (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

glutamate formiminotransferase deficiency (ISO)

intellectual disability (ISO)

myoepithelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (EXP)

1-aminobenzotriazole (ISO)

1-benzylpiperazine (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrotoluene (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

buspirone (EXP)

buta-1,3-diene (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

diiodine (EXP)

diquat (ISO)

disulfiram (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (EXP)

furan (EXP)

glafenine (EXP)

isoniazide (ISO)

methamphetamine (EXP)

methapyrilene (EXP)

methidathion (ISO)

monosodium L-glutamate (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

nimesulide (EXP)

paracetamol (EXP,ISO)

perfluorodecanoic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

propiconazole (ISO)

quercetin (ISO)

rac-1,2-dichloropropane (ISO)

resveratrol (ISO)

rotenone (ISO)

SCH 23390 (EXP)

sodium arsenite (EXP,ISO)

sodium perchlorate (EXP)

tauroursodeoxycholic acid (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoskeleton organization (IMP)

L-histidine catabolic process to glutamate and formamide (IEA)

L-histidine catabolic process to glutamate and formate (IEA)

L-histidine metabolic process (IEA)

Cellular Component

centriole (IEA)

cytosol (IEA,ISO)

endoplasmic reticulum (IDA)

endoplasmic reticulum-Golgi intermediate compartment (IDA)

Golgi apparatus (IEA,ISO)

Golgi membrane (IBA,IDA,IEA,ISO)

smooth endoplasmic reticulum membrane (IEA,ISO)

Molecular Function

catalytic activity (IEA)

folic acid binding (IEA)

formimidoyltetrahydrofolate cyclodeaminase activity (IBA,IDA,IEA,ISO,TAS)

glutamate formimidoyltransferase activity (IBA,IDA,IEA,ISO,TAS)

intermediate filament binding (TAS)

lyase activity (IEA)

microtubule binding (IDA,IEA,ISO)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

folate mediated one-carbon metabolic pathway (IEA)

folate metabolic pathway (ISO)

hereditary folate malabsorption pathway (ISO)

histidine metabolic pathway (IEA,ISO)

histidinemia pathway (ISO)

methotrexate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase.	Bashour AM and Bloom GS, J Biol Chem. 1998 Jul 31;273(31):19612-7.
2.	A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein.	Gao YS, etal., Eur J Cell Biol 2002 Jul;81(7):391-401.
3.	Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein.	Gao YS, etal., J Biol Chem 1998 Dec 11;273(50):33825-34.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
7.	Gene Data Set	MGD Curation, June 12, 2002
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2572277	PMID:12477932	PMID:12815595	PMID:14697341	PMID:15272307	PMID:19056867	PMID:19766735	PMID:23376485

Genomics

Comparative Map Data

Ftcd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,054,710 - 12,068,219 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	12,054,711 - 12,068,237 (-)	Ensembl				GRCr8
mRatBN7.2	20	12,055,203 - 12,068,717 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,055,208 - 12,068,735 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	12,751,494 - 12,765,024 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,112,414 - 12,125,946 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,584,199 - 12,597,724 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	12,806,957 - 12,820,466 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	12,806,957 - 12,820,466 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	14,965,126 - 14,978,635 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	12,470,291 - 12,483,807 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	13,553,681 - 13,567,051 (-)	NCBI		Celera
RGSC_v3.1	20	12,470,516 - 12,484,034 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

FTCD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	46,136,262 - 46,155,579 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	46,136,083 - 46,155,581 (-)	Ensembl			hg38	GRCh38
GRCh37	21	47,556,176 - 47,575,493 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	46,380,604 - 46,399,909 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	46,381,123 - 46,399,909	NCBI
Celera	21	32,668,510 - 32,687,862 (-)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	32,937,193 - 32,957,524 (-)	NCBI		HuRef
CHM1_1	21	47,116,995 - 47,136,320 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	44,514,323 - 44,534,996 (-)	NCBI		T2T-CHM13v2.0

Ftcd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	76,411,482 - 76,426,172 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	76,411,482 - 76,426,172 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	76,575,648 - 76,590,338 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	76,575,648 - 76,590,338 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	76,038,393 - 76,053,083 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	76,019,402 - 76,033,277 (+)	NCBI		MGSCv36	mm8
Celera	10	77,620,163 - 77,635,459 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.25	NCBI

Ftcd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	42,607,872 - 42,617,166 (-)	Ensembl
ChiLan1.0	NW_004955407	42,608,249 - 42,617,167 (-)	NCBI	ChiLan1.0	ChiLan1.0

FTCD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	42,237,586 - 42,262,376 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	37,109,542 - 37,134,237 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	32,481,042 - 32,501,932 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	45,734,647 - 45,753,437 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	45,734,825 - 45,753,400 (-)	Ensembl			panPan2	panpan1.1

FTCD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	39,451,557 - 39,464,249 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	39,275,159 - 39,464,715 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	38,679,583 - 38,692,067 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	39,092,693 - 39,105,364 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	39,092,651 - 39,105,751 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	38,954,390 - 38,967,042 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	38,914,802 - 38,927,725 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	39,433,241 - 39,445,917 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ftcd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	38,739,431 - 38,755,168 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936778	375,800 - 390,554 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936778	375,800 - 390,764 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FTCD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	13	218,617,763 - 218,632,226 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FTCD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	89,761,600 - 89,778,572 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	89,761,248 - 89,782,238 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	18,109,972 - 18,159,319 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ftcd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	31,276,314 - 31,289,063 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	31,279,868 - 31,288,600 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ftcd
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	106,555,989 - 106,569,810 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ftcd
254 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	216
Count of miRNA genes:	150
Interacting mature miRNAs:	170
Transcripts:	ENSRNOT00000001699
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8043920	15089182	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

UniSTS:259080

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	20	12,056,900 - 12,057,900 (+)	Marker Load Pipeline
mRatBN7.2	20	12,057,397 - 12,058,397 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	12,809,148 - 12,810,147	NCBI	Rnor6.0
Rnor_5.0	20	14,967,317 - 14,968,316	UniSTS	Rnor5.0
RGSC_v3.4	20	12,472,489 - 12,473,488	UniSTS	RGSC3.4
Celera	20	13,555,872 - 13,556,871	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	8	59	131	91	90	59	73	59	6	324	160	8	106	81	91	31	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF079233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001699 ⟹ ENSRNOP00000001699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	12,054,711 - 12,068,237 (-)	Ensembl
mRatBN7.2 Ensembl	20	12,055,208 - 12,068,735 (-)	Ensembl
Rnor_6.0 Ensembl	20	12,806,957 - 12,820,466 (-)	Ensembl

RefSeq Acc Id:

NM_053567 ⟹ NP_446019

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,054,710 - 12,068,219 (-)	NCBI
mRatBN7.2	20	12,055,207 - 12,068,717 (-)	NCBI
Rnor_6.0	20	12,806,957 - 12,820,466 (-)	NCBI
Rnor_5.0	20	14,965,126 - 14,978,635 (-)	NCBI
RGSC_v3.4	20	12,470,291 - 12,483,807 (-)	RGD
Celera	20	13,553,681 - 13,567,051 (-)	NCBI

Sequence:

show sequence

AATTCCACTCAGGTGCTGGCCATGTCCCAGTTGGTGGAATGTGTCCCCAACTTCTCAGAGGGGA
ACAACCAGGAGGTGATCGATGCCATTTCTCAAGCCATCTCCCAGACCCCAGGTTGTGTGCTGTT
GGACGTTGATGCTGGACCCTCCACCAACCGCACTGTCTACACTTTTGTGGGGCAGCCGGAGTGT
GTGGTCGAGGGAGCCCTCAGTGCTGCGCGAACAGCCTCACAGCTCATCGACATGAGGAAGCACA
AGGGAGAGCACCCTCGAATGGGTGCTCTGGATGTGTGTCCCTTCATCCCGGTGAGGGGCGTCAG
CATGGACGAGTGTGTGCTCTGTGCCAAGGCATTTGGGCAGCGGCTGGCAGAGGAACTGAATGTA
CCAGTGTACCTCTATGGTGAGGCGGCTCAGATGCCCAGTCGTCAGACCCTGCCAGCCATCCGGG
CTGGAGAGTATGAGGCCCTGCCTGAGAAGCTCAAACAGGCCGAGTGGGTGCCCGACTTTGGCCC
TAGCTCCTTTGTCCCCAGTTGGGGTGCCACTGTCACGGGTGCACGGAAATTCCTCATTGCGTTC
AATATCAATCTGCTAAGCACCAAGGAACAGGCCCACCGTATCGCTCTCAACCTGCGGGAGCAGG
GCCGAGGGAAAGACCAGCCGGGACGTCTGAAAAAGGTTCAGGGCATCGGCTGGTACCTAGAAGA
GAAGAACCTGGCTCAGGTGTCCACCAACCTCCTGGATTTTGAGGTCACGGCTCTGCACACAGTG
TACGAGGAGGCCCGCCGAGAGGCTCAGGAGCTGAATCTCCCAGTGGTGGGCTCACAGCTGGTGG
GCCTGGTGCCTCTGAAGGCCTTACTGGATGCCGCAGCCTTCTACTGTGACAAGGAGAAGCTGTT
TGTTCTGGAGGAGGAGCACCGGATTCGACTGGTGGTGAACCGGCTGGGTCTGGATTCCCTGGCG
CCCTTCGACCCAAAGGAGCGGATCATCGAGTACCTGGTCCCGGATAGTGGACCAGAACAGAGCC
TGCTGGACGCATCACTGCGTGCTTTTGTTCGGGAGGTGGGAGCCCGCTCTGCTGCCCCAGGAGG
CGGTTCCGTAGCCGCAGCTGTTGCAGCTCTGGGTGCAGCCCTGGCTTCTATGGTGGGCCAGATG
ACCTATGGCCGGCGCCAGTTTGATCACCTGGATTCCACAATGCGACGCTTGATCCCACCCTTCC
ATGCAGCCTCCGCCCAGCTGACTTCATTGGTGGACGCTGACGCGCGGGCTTTTGCTGCCTGTTT
GGGGGCAATAAAGCTGCCCAAGAATACGCCTGAAGAGAGGGACAGGCGCACATGTGCTCTGCAA
GAGGGGCTGAGACAGGCGGTCGCTGTGCCACTGAAACTGGCTGAGACGGTGTCCCAGCTATGGC
CGGCGCTGCAGGAGCTGGCCCAATGTGGCAACCTCTCTTGCTTGTCTGACCTGCAGGTGGCAGC
CAAAGCCTTGGAGACAGGTGTGTTTGGTGCGTACTTCAATGTGCTCATCAACCTGAAGGACATG
ACGGATGATGTATTTAAAGAGAAGACACGCCATCGAATCTCCAGCCTTCTGCAGGAAGCCAAGA
CCCAGGCTGCGCTGGTGCTGGGTAGCCTAGAAGCTCGGAAGGAGTGAAGAGATCGCTCCTCAGT
GAATGGTCCAACTTCCAGAATTCCTTACCTATCTTGCTTGGGGAGAAGACTCAGCCATGATATC
AGCAGGGTCAGGTTGGGGCTCTATAGACAGCTGTAGGATCAGAAGACCCAACAGAGGTGGTTTG
GGGTAGGGTATGGTAGGGCCTGATTGGGGGTGGTATCCCGACACTCTCTGTTATCTGTGGCTTC
TAGTAAAATTTGAACAGGTCCATTTTATGAGATTGTAGAAGACAAAAAGAACAGCAAGAGTTCT
GACTTGACCTCAGATCTTGGGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_446019	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC28849	(Get FASTA)	NCBI Sequence Viewer
	AAH91134	(Get FASTA)	NCBI Sequence Viewer
	EDL97137	(Get FASTA)	NCBI Sequence Viewer
	EDL97138	(Get FASTA)	NCBI Sequence Viewer
	EDL97139	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001699
	ENSRNOP00000001699.3
GenBank Protein	O88618	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446019 ⟸ NM_053567

- UniProtKB:

Q5BKB7 (UniProtKB/Swiss-Prot), O88618 (UniProtKB/Swiss-Prot), A6JKC1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQLVECVPNFSEGNNQEVIDAISQAISQTPGCVLLDVDAGPSTNRTVYTFVGQPECVVEGALS
AARTASQLIDMRKHKGEHPRMGALDVCPFIPVRGVSMDECVLCAKAFGQRLAEELNVPVYLYGE
AAQMPSRQTLPAIRAGEYEALPEKLKQAEWVPDFGPSSFVPSWGATVTGARKFLIAFNINLLST
KEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLEEKNLAQVSTNLLDFEVTALHTVYEEARRE
AQELNLPVVGSQLVGLVPLKALLDAAAFYCDKEKLFVLEEEHRIRLVVNRLGLDSLAPFDPKER
IIEYLVPDSGPEQSLLDASLRAFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQF
DHLDSTMRRLIPPFHAASAQLTSLVDADARAFAACLGAIKLPKNTPEERDRRTCALQEGLRQAV
AVPLKLAETVSQLWPALQELAQCGNLSCLSDLQVAAKALETGVFGAYFNVLINLKDMTDDVFKE
KTRHRISSLLQEAKTQAALVLGSLEARKE

hide sequence

Ensembl Acc Id:

ENSRNOP00000001699 ⟸ ENSRNOT00000001699

Protein Domains

Cyclodeaminase/cyclohydrolase Formiminotransferase C-terminal subdomain Formiminotransferase N-terminal subdomain

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88618-F1-model_v2	AlphaFold	O88618	1-541	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701514

Promoter ID:

EPDNEW_R12038

Type:

single initiation site

Name:

Ftcd_1

Description:

formimidoyltransferase cyclodeaminase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	12,820,499 - 12,820,559	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70915	AgrOrtholog
BioCyc Gene	G2FUF-4193	BioCyc
Ensembl Genes	ENSRNOG00000001261	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001699	ENTREZGENE
	ENSRNOT00000001699.7	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.120.680	UniProtKB/Swiss-Prot
	3.30.70.670	UniProtKB/Swiss-Prot
	3.30.990.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7369085	IMAGE-MGC_LOAD
InterPro	Cyclodeamin/CycHdrlase	UniProtKB/Swiss-Prot
	Formiminotransferase_C	UniProtKB/Swiss-Prot
	Formiminotransferase_C_sf	UniProtKB/Swiss-Prot
	Formiminotransferase_cat	UniProtKB/Swiss-Prot
	Formiminotransferase_N	UniProtKB/Swiss-Prot
	Formiminotransferase_N_sf	UniProtKB/Swiss-Prot
	FormiminoTrfase_cat_dom_sf	UniProtKB/Swiss-Prot
	Formintransfe-cycloase-like_sf	UniProtKB/Swiss-Prot
	FTCD	UniProtKB/Swiss-Prot
KEGG Report	rno:89833	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108634	IMAGE-MGC_LOAD
NCBI Gene	89833	ENTREZGENE
PANTHER	FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE	UniProtKB/Swiss-Prot
	FORMIMINOTRANSFERASE-CYCLODEAMINASE	UniProtKB/Swiss-Prot
Pfam	FTCD	UniProtKB/Swiss-Prot
	FTCD_C	UniProtKB/Swiss-Prot
	FTCD_N	UniProtKB/Swiss-Prot
PhenoGen	Ftcd	PhenoGen
RatGTEx	ENSRNOG00000001261	RatGTEx
SMART	FTCD	UniProtKB/Swiss-Prot
	FTCD_N	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF101262	UniProtKB/Swiss-Prot
	SSF55116	UniProtKB/Swiss-Prot
UniProt	A6JKC1	ENTREZGENE, UniProtKB/TrEMBL
	A6JKC2_RAT	UniProtKB/TrEMBL
	A6JKC3_RAT	UniProtKB/TrEMBL
	FTCD_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5BKB7	ENTREZGENE
UniProt Secondary	Q5BKB7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-09	Ftcd	formimidoyltransferase cyclodeaminase	Ftcd	formiminotransferase cyclodeaminase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Ftcd	formiminotransferase cyclodeaminase			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)