Cdc5l (cell division cycle 5-like) - Rat Genome Database

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Gene: Cdc5l (cell division cycle 5-like) Rattus norvegicus
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Symbol: Cdc5l
Name: cell division cycle 5-like
RGD ID: 70892
Description: Enables enzyme binding activity; leucine zipper domain binding activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to interleukin-2; cellular response to prolactin; and cellular response to wortmannin. Located in nuclear speck and perinuclear region of cytoplasm. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 3-chloropropane-1,2-diol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDC5 (cell division cycle 5 S. pombe homolog)-like; CDC5 (cell division cycle 5, S. pombe, homolog)-like; CDC5 cell division cycle 5-like; CDC5 cell division cycle 5-like (S. pombe); cdc5-like protein; cell division cycle 5-like (S. pombe); cell division cycle 5-like protein; cell division cycle 5-related protein; pombe Cdc5-related protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8923,062,397 - 23,100,901 (+)NCBIGRCr8
mRatBN7.2915,564,949 - 15,603,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,564,767 - 15,603,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,151,506 - 24,189,633 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,214,190 - 29,252,317 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,514,951 - 27,553,079 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,949,764 - 17,988,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,949,764 - 17,988,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,838,171 - 16,876,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,165,631 - 11,204,135 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,162,952 - 11,201,455 (+)NCBI
Celera913,308,462 - 13,346,957 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Cdc5lRatesophagus adenocarcinoma disease_progressionISOCDC5L (Homo sapiens)10047052protein:increased expression:esophageal mucosa (human)RGD 
Cdc5lRatLung Neoplasms  ISOCdc5l (Mus musculus)10047051mRNA:increased expression:lung (mouse)RGD 
Cdc5lRatosteosarcoma  ISOCDC5L (Homo sapiens)10047050DNA:amplification:cds (human)RGD 
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Cdc5lRatCAKUT  ISOCDC5L (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital anomalies of kidney and urinary tractClinVarPMID:27657687

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Original Reference(s)
Cdc5lRat(1->4)-beta-D-glucan multiple interactionsISOCdc5l (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CDC5L mRNACTDPMID:36331819
Cdc5lRat1,2-dimethylhydrazine decreases expressionISOCdc5l (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CDC5L mRNACTDPMID:22206623
Cdc5lRat1-chloro-2,4-dinitrobenzene affects bindingISOCDC5L (Homo sapiens)6480464Dinitrochlorobenzene binds to CDC5L proteinCTDPMID:32991956
Cdc5lRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOCdc5l (Mus musculus)64804642 more ...CTDPMID:30294300
Cdc5lRat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOCdc5l (Mus musculus)64804642 more ...CTDPMID:31388691
Cdc5lRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCdc5l (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CDC5L mRNACTDPMID:21570461 and PMID:24680724
Cdc5lRat3,3',5,5'-tetrabromobisphenol A increases expressionISOCDC5L (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of CDC5L proteinCTDPMID:31675489
Cdc5lRat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of CDC5L proteinCTDPMID:34915118
Cdc5lRataflatoxin B1 decreases methylationISOCDC5L (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of CDC5L geneCTDPMID:27153756
Cdc5lRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CDC5L mRNACTDPMID:16483693
Cdc5lRatantirheumatic drug increases expressionISOCDC5L (Homo sapiens)6480464Antirheumatic Agents results in increased expression of CDC5L mRNACTDPMID:24449571
Cdc5lRataristolochic acid A decreases expressionISOCDC5L (Homo sapiens)6480464aristolochic acid I results in decreased expression of CDC5L mRNACTDPMID:33212167
Cdc5lRatAroclor 1254 decreases expressionISOCdc5l (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC5L mRNACTDPMID:23650126
Cdc5lRatbenzo[a]pyrene increases expressionISOCdc5l (Mus musculus)6480464Benzo(a)pyrene results in increased expression of CDC5L mRNACTDPMID:22228805
Cdc5lRatbis(2-ethylhexyl) phthalate increases expressionISOCdc5l (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of CDC5L mRNACTDPMID:34319233
Cdc5lRatbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of CDC5L mRNACTDPMID:25181051
Cdc5lRatbisphenol A decreases expressionISOCDC5L (Homo sapiens)6480464bisphenol A results in decreased expression of CDC5L proteinCTDPMID:31675489
Cdc5lRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CDC5L mRNACTDPMID:34947998
Cdc5lRatBisphenol A diglycidyl ether affects splicingISOCdc5l (Mus musculus)6480464bisphenol A diglycidyl ether affects the splicing of CDC5L mRNACTDPMID:36464114
Cdc5lRatbisphenol AF affects splicingISOCdc5l (Mus musculus)6480464bisphenol AF affects the splicing of CDC5L mRNACTDPMID:36464114

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Biological Process
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Original Reference(s)
Cdc5lRatcellular response to fibroblast growth factor stimulus  IEP 10047049 RGD 
Cdc5lRatcellular response to interleukin-2  IEP 10047049 RGD 
Cdc5lRatcellular response to nerve growth factor stimulus  IDA 10045890 RGD 
Cdc5lRatcellular response to prolactin  IEP 61637 RGD 
Cdc5lRatcellular response to wortmannin  IDA 10045890 RGD 
Cdc5lRatDNA damage checkpoint signaling involved_inISSUniProtKB:Q994591600115GO_REF:0000024UniProtGO_REF:0000024
Cdc5lRatDNA damage checkpoint signaling involved_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatDNA damage checkpoint signaling involved_inISOCDC5L (Homo sapiens)1624291 PMID:24332808RGDPMID:24332808
Cdc5lRatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatG2/M transition of mitotic cell cycle  TAS 619664 RGD 
Cdc5lRatmRNA processing involved_inIEAUniProtKB-KW:KW-05071600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatmRNA splicing, via spliceosome involved_inISSUniProtKB:Q994591600115GO_REF:0000024UniProtGO_REF:0000024
Cdc5lRatmRNA splicing, via spliceosome involved_inIBAPANTHER:PTN000067719 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdc5lRatmRNA splicing, via spliceosome involved_inIEAInterPro:IPR0472421600115GO_REF:0000002InterProGO_REF:0000002
Cdc5lRatmRNA splicing, via spliceosome involved_inISOCDC5L (Homo sapiens)1624291 PMID:28076346RGDPMID:28076346
Cdc5lRatmRNA splicing, via spliceosome involved_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatpositive regulation of transcription by RNA polymerase II involved_inISOCDC5L (Homo sapiens)1624291 PMID:11082045RGDPMID:11082045
Cdc5lRatregulation of DNA-templated transcription  TAS 619664 RGD 
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Cellular Component
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Original Reference(s)
Cdc5lRatcatalytic step 2 spliceosome part_ofISOCDC5L (Homo sapiens)1624291 PMID:11991638RGDPMID:11991638
Cdc5lRatcatalytic step 2 spliceosome part_ofIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatcytoplasm part_ofISOCDC5L (Homo sapiens)1624291 PMID:9038199RGDPMID:9038199
Cdc5lRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cdc5lRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatcytoplasm part_ofIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatDNA replication factor A complex located_inISSUniProtKB:Q994591600115GO_REF:0000024UniProtGO_REF:0000024
Cdc5lRatDNA replication factor A complex located_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatDNA replication factor A complex located_inISOCDC5L (Homo sapiens)1624291 PMID:24332808RGDPMID:24332808
Cdc5lRatnuclear speck  IDA 619664 RGD 
Cdc5lRatnuclear speck located_inIEAUniProtKB-SubCell:SL-01861600115GO_REF:0000044UniProtGO_REF:0000044
Cdc5lRatnuclear speck located_inISOCDC5L (Homo sapiens)1624291 PMID:16332694RGDPMID:16332694
Cdc5lRatnuclear speck located_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatnucleoplasm located_inISOCDC5L (Homo sapiens)1624291 RGDGO_REF:0000052
Cdc5lRatnucleoplasm located_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Cdc5lRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatnucleus located_inISOCDC5L (Homo sapiens)1624291 PMID:20176811 and PMID:28076346RGDPMID:20176811 and PMID:28076346
Cdc5lRatnucleus located_inIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatperinuclear region of cytoplasm  IDA 10047049 RGD 
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Molecular Function
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Original Reference(s)
Cdc5lRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOCDC5L (Homo sapiens)1624291 PMID:11082045RGDPMID:11082045
Cdc5lRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN000836844 and UniProtKB:Q994591600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdc5lRatidentical protein binding enablesIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatidentical protein binding enablesISOCDC5L (Homo sapiens)1624291UniProtKB:Q99459 more ...RGDPMID:20176811 and PMID:20467437
Cdc5lRatleucine zipper domain binding  IPIDapk3 (Rattus norvegicus)619664 RGD 
Cdc5lRatprotein binding enablesIPIUniProtKB:Q9JMJ410047232PMID:16352598UniProt 
Cdc5lRatprotein binding enablesISOCDC5L (Homo sapiens)1624291UniProtKB:O43660 more ...RGDPMID:12927788 more ...
Cdc5lRatprotein kinase binding  IPIDapk3 (Rattus norvegicus)619664 RGD 
Cdc5lRatprotein phosphatase 1 binding  IPIPpp1r8 (Rattus norvegicus)10045998 RGD 
Cdc5lRatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Cdc5lRatRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
Cdc5lRatRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIBAPANTHER:PTN000836844 and UniProtKB:Q994591600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdc5lRatRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesISOCDC5L (Homo sapiens)1624291 PMID:11082045RGDPMID:11082045
Cdc5lRattranscription corepressor binding  IPIYwhab (Rattus norvegicus)10045890 RGD 
Cdc5lRatWD40-repeat domain binding enablesISSUniProtKB:Q994591600115GO_REF:0000024UniProtGO_REF:0000024
Cdc5lRatWD40-repeat domain binding enablesISOCDC5L (Homo sapiens)1624291 PMID:20176811RGDPMID:20176811
Cdc5lRatWD40-repeat domain binding enablesIEAUniProtKB:Q99459 and ensembl:ENSP000003605321600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
Cdc5lRatspliceosome pathway   ISOCDC5L (Homo sapiens)9686094 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Cdc5lRatspliceosome pathway   IEA 6907045 KEGGrno:03040

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#
Reference Title
Reference Citation
1. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Bonner AE, etal., Oncogene. 2004 Feb 5;23(5):1166-76.
2. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. Boudrez A, etal., J Biol Chem. 2000 Aug 18;275(33):25411-7.
3. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
4. DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. Engemann H, etal., Nucleic Acids Res 2002 Mar 15;30(6):1408-17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Hansel DE, etal., Am J Surg Pathol. 2005 Mar;29(3):390-9.
7. Prolactin, interleukin-2 and FGF-2 stimulate expression, nuclear distribution and DNA-binding of rat homolog of pombe Cdc5 in Nb2 T lymphoma cells. Johnson LM and Too CK, Mol Cell Endocrinol. 2001 Nov 26;184(1-2):151-61.
8. Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. Lu XY, etal., Mol Cancer Res. 2008 Jun;6(6):937-46. doi: 10.1158/1541-7786.MCR-07-2115.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Differential expression of elongation factor-2, alpha4 phosphoprotein and Cdc5-like protein in prolactin-dependent/independent rat lymphoid cells. Too CK Mol Cell Endocrinol 1997 Aug 8;131(2):221-32.
17. Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions. Urano Y, etal., J Biol Chem. 2006 Mar 17;281(11):7498-514. Epub 2005 Dec 13.
18. Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation. Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.
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PMID:9038199   PMID:11082045   PMID:11991638   PMID:12477932   PMID:16332694   PMID:19946888   PMID:20176811   PMID:22681889   PMID:24332808   PMID:28076346  



Cdc5l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8923,062,397 - 23,100,901 (+)NCBIGRCr8
mRatBN7.2915,564,949 - 15,603,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,564,767 - 15,603,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,151,506 - 24,189,633 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,214,190 - 29,252,317 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,514,951 - 27,553,079 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,949,764 - 17,988,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,949,764 - 17,988,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,838,171 - 16,876,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,165,631 - 11,204,135 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,162,952 - 11,201,455 (+)NCBI
Celera913,308,462 - 13,346,957 (+)NCBICelera
Cytogenetic Map9q12NCBI
CDC5L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,387,706 - 44,450,425 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl644,387,706 - 44,450,425 (+)EnsemblGRCh38hg38GRCh38
GRCh37644,355,443 - 44,418,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,463,280 - 44,522,758 (+)NCBINCBI36Build 36hg18NCBI36
Build 34644,463,279 - 44,522,757NCBI
Celera645,908,480 - 45,967,835 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef644,077,869 - 44,140,670 (+)NCBIHuRef
CHM1_1644,358,890 - 44,421,686 (+)NCBICHM1_1
T2T-CHM13v2.0644,222,452 - 44,285,059 (+)NCBIT2T-CHM13v2.0
Cdc5l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,702,809 - 45,744,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1745,702,810 - 45,744,663 (-)EnsemblGRCm39 Ensembl
GRCm381745,391,887 - 45,433,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,391,884 - 45,433,737 (-)EnsemblGRCm38mm10GRCm38
MGSCv371745,528,836 - 45,570,656 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361744,855,468 - 44,897,288 (-)NCBIMGSCv36mm8
Celera1748,822,530 - 48,866,019 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1722.36NCBI
Cdc5l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,990,613 - 10,032,034 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,990,613 - 10,032,034 (+)NCBIChiLan1.0ChiLan1.0
CDC5L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,891,113 - 58,955,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1654,761,126 - 54,821,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,983,840 - 44,043,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1645,265,845 - 45,326,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,265,845 - 45,326,383 (+)Ensemblpanpan1.1panPan2
CDC5L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,779,936 - 12,822,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,780,010 - 12,822,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,807,973 - 12,851,031 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01213,266,108 - 13,309,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1213,266,132 - 13,309,158 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,791,651 - 12,835,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,879,429 - 12,922,495 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,973,455 - 13,016,504 (+)NCBIUU_Cfam_GSD_1.0
Cdc5l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,262,000 - 48,311,662 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647615,648,678 - 15,698,106 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647615,647,470 - 15,698,095 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC5L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,384,556 - 39,431,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1739,384,397 - 39,427,729 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,306,065 - 45,349,669 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC5L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,727,185 - 27,785,233 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1727,722,819 - 27,785,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604444,437,105 - 44,495,930 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc5l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475415,477,193 - 15,517,636 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475415,477,188 - 15,517,656 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cdc5l
282 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
9 17975859 17975860 A C snv WKY/NHsd (RGD) View more Information
9 17975864 17975865 C A snv WKY/NHsd (RGD) View more Information
9 17975865 17975866 C T snv WKY/NHsd (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:45
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000027264
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat

1 to 10 of 18 rows
RH125755  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,603,111 - 15,603,365 (+)MAPPERmRatBN7.2
Rnor_6.0917,988,173 - 17,988,426NCBIRnor6.0
Rnor_5.0916,876,580 - 16,876,833UniSTSRnor5.0
RGSC_v3.4911,203,794 - 11,204,047UniSTSRGSC3.4
Celera913,346,616 - 13,346,869UniSTS
Cytogenetic Map9q12UniSTS
RH131317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,603,052 - 15,603,233 (+)MAPPERmRatBN7.2
Rnor_6.0917,988,114 - 17,988,294NCBIRnor6.0
Rnor_5.0916,876,521 - 16,876,701UniSTSRnor5.0
RGSC_v3.4911,203,735 - 11,203,915UniSTSRGSC3.4
Celera913,346,557 - 13,346,737UniSTS
RH 3.4 Map978.6UniSTS
Cytogenetic Map9q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000027264   ⟹   ENSRNOP00000027264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,564,767 - 15,603,450 (+)Ensembl
Rnor_6.0 Ensembl917,949,764 - 17,988,509 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112966   ⟹   ENSRNOP00000079717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,564,767 - 15,591,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120250   ⟹   ENSRNOP00000087958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,566,784 - 15,603,450 (+)Ensembl
RefSeq Acc Id: NM_053527   ⟹   NP_445979
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,062,397 - 23,100,899 (+)NCBI
mRatBN7.2915,564,949 - 15,603,453 (+)NCBI
Rnor_6.0917,949,764 - 17,988,514 (+)NCBI
Rnor_5.0916,838,171 - 16,876,921 (+)NCBI
RGSC_v3.4911,165,631 - 11,204,135 (+)RGD
Celera913,308,462 - 13,346,957 (+)RGD
Sequence:
RefSeq Acc Id: XM_063267788   ⟹   XP_063123858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,080,080 - 23,100,901 (+)NCBI
Protein RefSeqs NP_445979 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123858 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD05365 (Get FASTA)   NCBI Sequence Viewer  
  AAI61839 (Get FASTA)   NCBI Sequence Viewer  
  EDM18727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027264
  ENSRNOP00000027264.4
GenBank Protein O08837 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445979   ⟸   NM_053527
- UniProtKB: O08837 (UniProtKB/Swiss-Prot),   B1WBQ0 (UniProtKB/TrEMBL),   A0A8I6A562 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027264   ⟸   ENSRNOT00000027264
Ensembl Acc Id: ENSRNOP00000079717   ⟸   ENSRNOT00000112966
Ensembl Acc Id: ENSRNOP00000087958   ⟸   ENSRNOT00000120250
RefSeq Acc Id: XP_063123858   ⟸   XM_063267788
- Peptide Label: isoform X1
HTH myb-type   Myb-like

Name Modeler Protein Id AA Range Protein Structure
AF-O08837-F1-model_v2 AlphaFold O08837 1-802 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696548
Promoter ID:EPDNEW_R7072
Type:multiple initiation site
Name:Cdc5l_1
Description:cell division cycle 5-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,949,752 - 17,949,812EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28161 BioCyc
Ensembl Genes ENSRNOG00000019975 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027264 ENTREZGENE
  ENSRNOT00000027264.5 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125496 IMAGE-MGC_LOAD
  IMAGE:9101355 IMAGE-MGC_LOAD
InterPro CDC5L/Cef1 UniProtKB/Swiss-Prot
  Cdc5p/Cef1 UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Myb_dom UniProtKB/Swiss-Prot
  SANT/Myb UniProtKB/Swiss-Prot
  SANT_CDC5L_II UniProtKB/Swiss-Prot
KEGG Report rno:85434 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187349 IMAGE-MGC_LOAD
  MGC:93301 IMAGE-MGC_LOAD
NCBI Gene 85434 ENTREZGENE
PANTHER CELL DIVISION CYCLE 5-LIKE PROTEIN UniProtKB/Swiss-Prot
  CELL DIVISION CYCLE 5-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam Myb_Cef UniProtKB/Swiss-Prot
  Myb_DNA-bind_6 UniProtKB/Swiss-Prot
PhenoGen Cdc5l PhenoGen
PROSITE HTH_MYB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019975 RatGTEx
SMART SANT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt A0A8I5ZNY5_RAT UniProtKB/TrEMBL
  A0A8I6A562 ENTREZGENE, UniProtKB/TrEMBL
  B1WBQ0 ENTREZGENE, UniProtKB/TrEMBL
  CDC5L_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc5l  cell division cycle 5-like  Cdc5l  CDC5 cell division cycle 5-like (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cdc5l  CDC5 cell division cycle 5-like (S. pombe)  Cdc5l  cell division cycle 5-like (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cdc5l  cell division cycle 5-like (S. pombe)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_physical_interaction binds the leucine zipper domain of DAP-like kinase (Dlk), binding occurs via the Cdc5l C-terminal region between residues 500 and 802 619664
gene_regulation differential display shows transcription upregulated by prolactin 61637