RGD Reference Report - Splicing and beyond: the many faces of the Prp19 complex. - Rat Genome Database

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Splicing and beyond: the many faces of the Prp19 complex.

Authors: Chanarat, S  Strasser, K 
Citation: Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
RGD ID: 9686094
Pubmed: PMID:23742842   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbamcr.2013.05.023   (Journal Full-text)

The conserved Prp19 complex (Prp19C) - also known as NineTeen Complex (NTC) - functions in several processes of paramount importance for cellular homeostasis. NTC/Prp19C was discovered as a complex that functions in splicing and more specifically during the catalytic activation of the spliceosome. More recent work revealed that NTC/Prp19C plays a role in transcription elongation in Saccharomyces cerevisiae and in genome maintenance in higher eukaryotes. In addition, mouse PRP19 might ubiquity late proteins targeted for degradation and guide them to the proteasome. Furthermore, NTC/Prp19C has been implicated in lipid droplet biogenesis. In the future, the molecular function of NTC/Prp19C in all of these processes needs to be refined or elucidated. Most of NTC/Prp19C's functions have been shown in only one or few organisms. However, since this complex is highly conserved it is likely that it has the same functions across all species. Moreover, one NTC/Prp19C or different subcomplexes could function in the above-mentioned processes. Intriguingly, NTC/Prp19C might link these different processes to ensure an optimal coordination of cellular processes. Thus, many important questions about the functions of this interesting complex remain to be investigated. In this review we discuss the different functions of NTC/Prp19C focusing on the novel and emerging ones as well as open questions.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
spliceosome pathway   TAS 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094; 9686094 RGD 
spliceosome pathway   ISOAQR (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOBCAS2 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOBUD31 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOCCDC12 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOCDC5L (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOCRNKL1 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOCTNNBL1 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOCWC15 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOHSPA8 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOISY1 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOPLRG1 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOPPIE (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOPPIL1 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOPRPF19 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISORBM22 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOSNW1 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOSYF2 (Homo sapiens)9686094; 9686094 RGD 
spliceosome pathway   ISOXAB2 (Homo sapiens)9686094; 9686094 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Aqr  (aquarius intron-binding spliceosomal factor)
Bcas2  (BCAS2, pre-mRNA processing factor)
Bud31  (BUD31 homolog)
Ccdc12  (coiled-coil domain containing 12)
Cdc5l  (cell division cycle 5-like)
Crnkl1  (crooked neck pre-mRNA splicing factor 1)
Ctnnbl1  (catenin, beta like 1)
Cwc15  (CWC15 spliceosome-associated protein)
Hspa8  (heat shock protein family A (Hsp70) member 8)
Isy1  (ISY1 splicing factor homolog)
Plrg1  (pleiotropic regulator 1)
Ppie  (peptidylprolyl isomerase E)
Ppil1  (peptidylprolyl isomerase like 1)
Prpf19  (pre-mRNA processing factor 19)
Rbm22  (RNA binding motif protein 22)
Snw1  (SNW domain containing 1)
Syf2  (SYF2 pre-mRNA-splicing factor)
Xab2  (XPA binding protein 2)

Genes (Mus musculus)
Aqr  (aquarius)
Bcas2  (BCAS2 pre-mRNA processing factor)
Bud31  (BUD31 homolog)
Ccdc12  (coiled-coil domain containing 12)
Cdc5l  (cell division cycle 5-like)
Crnkl1  (crooked neck pre-mRNA splicing factor 1)
Ctnnbl1  (catenin, beta like 1)
Cwc15  (CWC15 spliceosome-associated protein)
Hspa8  (heat shock protein 8)
Isy1  (ISY1 splicing factor homolog)
Plrg1  (pleiotropic regulator 1)
Ppie  (peptidylprolyl isomerase E (cyclophilin E))
Ppil1  (peptidylprolyl isomerase (cyclophilin)-like 1)
Prpf19  (pre-mRNA processing factor 19)
Rbm22  (RNA binding motif protein 22)
Snw1  (SNW domain containing 1)
Syf2  (SYF2 homolog, RNA splicing factor (S. cerevisiae))
Xab2  (XPA binding protein 2)

Genes (Homo sapiens)
AQR  (aquarius intron-binding spliceosomal factor)
BCAS2  (BCAS2 pre-mRNA processing factor)
BUD31  (BUD31 homolog)
CCDC12  (coiled-coil domain containing 12)
CDC5L  (cell division cycle 5 like)
CRNKL1  (crooked neck pre-mRNA splicing factor 1)
CTNNBL1  (catenin beta like 1)
CWC15  (CWC15 spliceosome associated protein homolog)
HSPA8  (heat shock protein family A (Hsp70) member 8)
ISY1  (ISY1 splicing factor homolog)
PLRG1  (pleiotropic regulator 1)
PPIE  (peptidylprolyl isomerase E)
PPIL1  (peptidylprolyl isomerase like 1)
PRPF19  (pre-mRNA processing factor 19)
RBM22  (RNA binding motif protein 22)
SNW1  (SNW domain containing 1)
SYF2  (SYF2 pre-mRNA splicing factor)
XAB2  (XPA binding protein 2)


Additional Information