Nradd (neurotrophin receptor associated death domain) - Rat Genome Database

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Gene: Nradd (neurotrophin receptor associated death domain) Rattus norvegicus
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Symbol: Nradd
Name: neurotrophin receptor associated death domain
RGD ID: 708524
Description: Enables neurotrophin p75 receptor binding activity. Involved in in utero embryonic development. Located in cell body membrane and neuron projection membrane; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: death domain-containing membrane protein NRADD; LOC246143; neurotrophin receptor alike death domain protein; neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein; NRH2; p75-like apoptosis-inducing death domain protein; p75-like apoptosis-inducing death domain protein PLAIDD; PLAIDD
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,478,055 - 119,481,336 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,477,240 - 119,481,214 (-)EnsemblGRCr8
mRatBN7.28110,599,667 - 110,603,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,599,667 - 110,603,149 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,214,649 - 116,217,623 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,413,844 - 114,416,818 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,256,643 - 112,259,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,890,402 - 118,893,712 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,890,399 - 118,893,702 (-)Ensemblrn6Rnor6.0
Rnor_5.08118,231,589 - 118,234,887 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,002,319 - 115,005,292 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,884,040 - 109,887,013 (-)NCBICelera
RGSC_v3.18115,021,773 - 115,024,747 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. Frankowski H, etal., Neuromolecular Med 2002;1(3):153-70.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. Wang X, etal., Cell Death Differ 2003 May;10(5):580-91.
Additional References at PubMed
PMID:15280425  


Genomics

Comparative Map Data
Nradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,478,055 - 119,481,336 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,477,240 - 119,481,214 (-)EnsemblGRCr8
mRatBN7.28110,599,667 - 110,603,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,599,667 - 110,603,149 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,214,649 - 116,217,623 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,413,844 - 114,416,818 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,256,643 - 112,259,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,890,402 - 118,893,712 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,890,399 - 118,893,702 (-)Ensemblrn6Rnor6.0
Rnor_5.08118,231,589 - 118,234,887 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,002,319 - 115,005,292 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,884,040 - 109,887,013 (-)NCBICelera
RGSC_v3.18115,021,773 - 115,024,747 (-)NCBI
Cytogenetic Map8q32NCBI
Nradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,450,203 - 110,453,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,450,203 - 110,453,520 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389110,621,135 - 110,624,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)Ensemblmm10GRCm38
MGSCv379110,523,639 - 110,526,897 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369110,465,951 - 110,469,209 (-)NCBIMGSCv36mm8
Celera9110,351,068 - 110,354,326 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.26NCBI

Variants

.
Variants in Nradd
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:112
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000028416
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
BI278423  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08118,894,058 - 118,894,267NCBIRnor6.0
Celera8109,887,473 - 109,887,682UniSTS
RH 3.4 Map81191.4UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 87 59 6 351 187 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028416   ⟹   ENSRNOP00000028416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,478,054 - 119,480,054 (-)Ensembl
mRatBN7.2 Ensembl8110,599,667 - 110,603,149 (-)Ensembl
Rnor_6.0 Ensembl8118,890,399 - 118,893,702 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140942   ⟹   ENSRNOP00000112382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,477,240 - 119,481,214 (-)Ensembl
RefSeq Acc Id: NM_139259   ⟹   NP_640352
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,478,241 - 119,481,214 (-)NCBI
mRatBN7.28110,599,853 - 110,602,826 (-)NCBI
Rnor_6.08118,890,588 - 118,893,561 (-)NCBI
Rnor_5.08118,231,589 - 118,234,887 (-)NCBI
RGSC_v3.48115,002,319 - 115,005,292 (-)RGD
Celera8109,884,040 - 109,887,013 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243921   ⟹   XP_006243983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,478,055 - 119,481,336 (-)NCBI
mRatBN7.28110,599,667 - 110,603,068 (-)NCBI
Rnor_6.08118,890,402 - 118,893,712 (-)NCBI
Rnor_5.08118,231,589 - 118,234,887 (-)NCBI
Sequence:
RefSeq Acc Id: NP_640352   ⟸   NM_139259
- UniProtKB: Q8K5A8 (UniProtKB/Swiss-Prot),   G3V8U7 (UniProtKB/Swiss-Prot),   Q8K5A9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243983   ⟸   XM_006243921
- Peptide Label: isoform X1
- UniProtKB: A6I3F1 (UniProtKB/TrEMBL),   A6I3F2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028416   ⟸   ENSRNOT00000028416
Ensembl Acc Id: ENSRNOP00000112382   ⟸   ENSRNOT00000140942
Protein Domains
Death

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K5A9-F1-model_v2 AlphaFold Q8K5A9 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696333
Promoter ID:EPDNEW_R6857
Type:initiation region
Name:Nradd_1
Description:neurotrophin receptor associated death domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08118,893,557 - 118,893,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708524 AgrOrtholog
BioCyc Gene G2FUF-29062 BioCyc
Ensembl Genes ENSRNOG00000020936 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000140942 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  6.10.250.1780 UniProtKB/Swiss-Prot
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  Neurotrophin_rcpt-DD UniProtKB/Swiss-Prot
  TNFR16_TM UniProtKB/Swiss-Prot
KEGG Report rno:246143 UniProtKB/Swiss-Prot
NCBI Gene 246143 ENTREZGENE
PANTHER DEATH DOMAIN-CONTAINING MEMBRANE PROTEIN NRADD UniProtKB/Swiss-Prot
  TUMOR NECROSIS FACTOR RECEPTOR UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot
  TNFR_16_TM UniProtKB/Swiss-Prot
PhenoGen Nradd PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020936 RatGTEx
SMART DEATH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
UniProt A0A8L2QFJ0_RAT UniProtKB/TrEMBL
  A6I3F1 ENTREZGENE, UniProtKB/TrEMBL
  A6I3F2 ENTREZGENE, UniProtKB/TrEMBL
  A6I3F4_RAT UniProtKB/TrEMBL
  G3V8U7 ENTREZGENE
  NRADD_RAT UniProtKB/Swiss-Prot
  Q8K5A8 ENTREZGENE
  Q8K5A9 ENTREZGENE
UniProt Secondary G3V8U7 UniProtKB/Swiss-Prot
  Q8K5A8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Nradd  neurotrophin receptor associated death domain  LOC246143  p75-like apoptosis-inducing death domain protein PLAIDD  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference