Vom2r44 (vomeronasal 2 receptor 44) - Rat Genome Database

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Gene: Vom2r44 (vomeronasal 2 receptor 44) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r44 (Ensembl: Vmn2r1)
Name: vomeronasal 2 receptor 44
RGD ID: 708515
Description: Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be active in plasma membrane; INTERACTS WITH acetamide; ammonium chloride; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-sensing receptor like 1; Casrl1; LOC266778; tissue-type vomeronasal neurons putative pheromone receptor V2R2; vomeronasal type-2 receptor 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82150,643,126 - 150,685,691 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2150,650,058 - 150,685,691 (+)EnsemblGRCr8
mRatBN7.22148,497,150 - 148,536,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2148,500,170 - 148,531,880 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2155,229,150 - 155,260,143 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02153,278,626 - 153,309,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02147,911,304 - 147,942,304 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02154,601,995 - 154,636,154 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2154,604,832 - 154,639,158 (+)Ensemblrn6Rnor6.0
Rnor_5.02173,985,885 - 174,021,867 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42153,854,454 - 153,889,656 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2142,775,715 - 142,806,262 (+)NCBICelera
RGSC_v3.12153,834,901 - 153,839,711 (+)NCBI
Cytogenetic Map2q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
dendrite  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ. Martini S, etal., J Neurosci 2001 Feb 1;21(3):843-8.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. A new multigene family of putative pheromone receptors. Ryba NJ and Tirindelli R, Neuron 1997 Aug;19(2):371-9.
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r44
139 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000013777
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 63 153 91 90 59 79 59 6 336 174 11 132 80 91 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000013777   ⟹   ENSRNOP00000013778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2154,604,832 - 154,639,158 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132683   ⟹   ENSRNOP00000099000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2150,650,058 - 150,685,691 (+)Ensembl
RefSeq Acc Id: NM_001415021   ⟹   NP_001401950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,646,806 - 150,685,691 (+)NCBI
mRatBN7.22148,497,150 - 148,536,036 (+)NCBI
RefSeq Acc Id: XM_006232438   ⟹   XP_006232500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,649,271 - 150,685,691 (+)NCBI
mRatBN7.22148,499,605 - 148,536,036 (+)NCBI
Rnor_6.02154,604,414 - 154,636,154 (+)NCBI
Rnor_5.02173,985,885 - 174,021,867 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590655   ⟹   XP_017446144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,643,126 - 150,685,691 (+)NCBI
mRatBN7.22148,497,150 - 148,536,036 (+)NCBI
Rnor_6.02154,601,995 - 154,636,154 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001401950 (Get FASTA)   NCBI Sequence Viewer  
  XP_006232500 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC08416 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034693.8
  ENSRNOP00000099000
  ENSRNOP00000099000.1
RefSeq Acc Id: XP_006232500   ⟸   XM_006232438
- Peptide Label: isoform X1
- UniProtKB: G3V7C5 (UniProtKB/TrEMBL),   F1LQ12 (UniProtKB/TrEMBL),   A6JVP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446144   ⟸   XM_017590655
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000013778   ⟸   ENSRNOT00000013777
RefSeq Acc Id: NP_001401950   ⟸   NM_001415021
Ensembl Acc Id: ENSRNOP00000099000   ⟸   ENSRNOT00000132683
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQ12-F1-model_v2 AlphaFold F1LQ12 1-824 view protein structure
AF-G3V7C5-F1-model_v2 AlphaFold G3V7C5 1-912 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708515 AgrOrtholog
BioCyc Gene G2FUF-52922 BioCyc
Ensembl Genes ENSRNOG00000010268 Ensembl
  ENSRNOG00000030104 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000078605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031015.8 UniProtKB/TrEMBL
  ENSRNOT00000132683 ENTREZGENE
  ENSRNOT00000132683.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene 266778 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL TYPE-2 RECEPTOR 1 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r44 PhenoGen
PRINTS CASENSINGR UniProtKB/TrEMBL
  GPCRMGR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010268 RatGTEx
  ENSRNOG00000030104 RatGTEx
  ENSRNOG00000078605 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0ABK0L6C7_RAT UniProtKB/TrEMBL
  A6JVP8 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ12 ENTREZGENE, UniProtKB/TrEMBL
  G3V7C5 ENTREZGENE
UniProt Secondary G3V7C5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-01 Vom2r44  vomeronasal 2 receptor 44  Casrl1  calcium-sensing receptor like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Casrl1  calcium-sensing receptor like 1      Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference