Cdk5rap2 (CDK5 regulatory subunit associated protein 2) - Rat Genome Database

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Gene: Cdk5rap2 (CDK5 regulatory subunit associated protein 2) Rattus norvegicus
Analyze
Symbol: Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
RGD ID: 708451
Description: Predicted to enable several functions, including calmodulin binding activity; protein kinase binding activity; and tubulin binding activity. Involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and perinuclear region of cytoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in microtubule plus-end; mitotic spindle pole; and pericentriolar material. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to human CDK5RAP2 (CDK5 regulatory subunit associated protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDK5 activator-binding protein C48; CDK5 regulatory subunit-associated protein 2; LOC286919
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8588,807,402 - 88,976,005 (-)NCBIGRCr8
mRatBN7.2583,792,282 - 83,961,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl583,792,284 - 83,960,782 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx586,182,820 - 86,351,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0588,000,151 - 88,168,819 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0587,975,837 - 88,144,496 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0586,387,238 - 86,554,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl586,387,078 - 86,554,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0590,474,206 - 90,641,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4587,564,010 - 87,738,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1587,569,157 - 87,585,659 (-)NCBI
Celera582,598,401 - 82,765,611 (-)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aconitine  (EXP)
acrolein  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dibutyl phthalate  (EXP)
Enterolactone  (ISO)
fenvalerate  (EXP)
FR900359  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (IEA,ISO)
centrosome  (IEA,ISO,ISS)
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
gamma-tubulin ring complex  (IEA,ISO)
Golgi apparatus  (IEA,ISO,ISS)
microtubule  (ISO,ISS)
microtubule plus-end  (IBA,IEA,ISO,ISS)
mitotic spindle pole  (IBA,IEA,ISO)
pericentriolar material  (IBA,IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO,ISS)
spindle pole  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning of three novel neuronal Cdk5 activator binding proteins. Ching YP, etal., Gene 2000 Jan 25;242(1-2):285-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Previously described sequence variant in CDK5RAP2 gene in a Pakistani family with autosomal recessive primary microcephaly. Hassan MJ, etal., BMC Med Genet. 2007 Sep 1;8:58.
4. Clinical and cellular features in patients with primary autosomal recessive microcephaly and a novel CDK5RAP2 mutation. Issa L, etal., Orphanet J Rare Dis. 2013 Apr 15;8:59. doi: 10.1186/1750-1172-8-59.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Identification of a common protein association region in the neuronal Cdk5 activator. Wang X, etal., J Biol Chem 2000 Oct 13;275(41):31763-9.
10. Mutations in CDK5RAP2 cause Seckel syndrome. Yigit G, etal., Mol Genet Genomic Med. 2015 Sep;3(5):467-80. doi: 10.1002/mgg3.158. Epub 2015 May 24.
Additional References at PubMed
PMID:14654843   PMID:17920017   PMID:17959831   PMID:18042621   PMID:19056867   PMID:19282672   PMID:19543530   PMID:19553473   PMID:20460369   PMID:20466722   PMID:20471352   PMID:20627074  
PMID:21399614   PMID:22179047   PMID:23376485   PMID:25220058   PMID:25657325   PMID:26297806   PMID:26485573   PMID:26550838   PMID:28057765   PMID:29162697  


Genomics

Comparative Map Data
Cdk5rap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8588,807,402 - 88,976,005 (-)NCBIGRCr8
mRatBN7.2583,792,282 - 83,961,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl583,792,284 - 83,960,782 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx586,182,820 - 86,351,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0588,000,151 - 88,168,819 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0587,975,837 - 88,144,496 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0586,387,238 - 86,554,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl586,387,078 - 86,554,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0590,474,206 - 90,641,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4587,564,010 - 87,738,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1587,569,157 - 87,585,659 (-)NCBI
Celera582,598,401 - 82,765,611 (-)NCBICelera
Cytogenetic Map5q31NCBI
CDK5RAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389120,388,875 - 120,580,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9120,388,875 - 120,580,170 (-)EnsemblGRCh38hg38GRCh38
GRCh379123,151,153 - 123,342,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,190,968 - 122,382,258 (-)NCBINCBI36Build 36hg18NCBI36
Build 349120,230,701 - 120,421,991NCBI
Celera993,799,407 - 93,990,706 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef992,769,151 - 92,960,484 (-)NCBIHuRef
CHM1_19123,298,715 - 123,489,623 (-)NCBICHM1_1
T2T-CHM13v2.09132,583,189 - 132,774,493 (-)NCBIT2T-CHM13v2.0
Cdk5rap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39470,135,092 - 70,328,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl470,135,093 - 70,328,680 (-)EnsemblGRCm39 Ensembl
GRCm38470,216,855 - 70,410,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl470,216,856 - 70,410,443 (-)EnsemblGRCm38mm10GRCm38
MGSCv37469,884,058 - 70,071,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36469,709,385 - 69,896,728 (-)NCBIMGSCv36mm8
Celera468,823,988 - 69,004,683 (-)NCBICelera
Cytogenetic Map4C2NCBI
Cdk5rap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554197,412,331 - 7,610,353 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554197,412,177 - 7,606,883 (+)NCBIChiLan1.0ChiLan1.0
CDK5RAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,765,717 - 18,953,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1918,768,068 - 18,956,572 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0991,519,179 - 91,707,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19119,867,654 - 120,055,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9119,868,015 - 120,055,608 (-)Ensemblpanpan1.1panPan2
CDK5RAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11173,548,003 - 73,693,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1173,548,038 - 73,690,199 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1171,961,518 - 72,114,600 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01174,680,442 - 74,834,175 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1174,680,482 - 74,823,995 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11173,193,623 - 73,346,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01173,225,707 - 73,378,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01173,962,635 - 74,115,691 (-)NCBIUU_Cfam_GSD_1.0
Cdk5rap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,132,141 - 189,313,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364878,900,530 - 9,081,527 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364878,900,375 - 9,081,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK5RAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,466,942 - 260,648,161 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,465,809 - 260,648,070 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21292,619,819 - 292,719,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK5RAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,999,203 - 19,186,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,999,213 - 19,186,785 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603523,820,723 - 24,007,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk5rap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476014,736,104 - 14,930,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476014,736,273 - 14,930,168 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdk5rap2
633 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:169
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000007710
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)58384059897059958Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
RH104241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2583,912,064 - 83,912,200 (+)MAPPERmRatBN7.2
Rnor_6.0586,505,863 - 86,505,998NCBIRnor6.0
Rnor_5.0590,593,083 - 90,593,218UniSTSRnor5.0
RGSC_v3.4587,684,740 - 87,684,875UniSTSRGSC3.4
Celera582,718,075 - 82,718,210UniSTS
Cytogenetic Map5q31UniSTS
RH130294  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2583,959,417 - 83,959,598 (+)MAPPERmRatBN7.2
Rnor_6.0586,552,738 - 86,552,918NCBIRnor6.0
Rnor_5.0590,639,958 - 90,640,138UniSTSRnor5.0
RGSC_v3.4587,736,977 - 87,737,157UniSTSRGSC3.4
Celera582,764,247 - 82,764,427UniSTS
RH 3.4 Map5656.1UniSTS
Cytogenetic Map5q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF177478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB806103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX524852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF541099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007710   ⟹   ENSRNOP00000007710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl583,792,284 - 83,960,782 (-)Ensembl
Rnor_6.0 Ensembl586,387,240 - 86,554,102 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083340   ⟹   ENSRNOP00000073851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl583,796,812 - 83,960,782 (-)Ensembl
Rnor_6.0 Ensembl586,387,078 - 86,554,102 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095333   ⟹   ENSRNOP00000086335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl583,796,812 - 83,960,782 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095599   ⟹   ENSRNOP00000086004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl583,796,812 - 83,960,782 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118617   ⟹   ENSRNOP00000096134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl583,796,812 - 83,960,782 (-)Ensembl
RefSeq Acc Id: NM_173134   ⟹   NP_775157
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,975,897 (-)NCBI
mRatBN7.2583,792,284 - 83,960,782 (-)NCBI
Rnor_6.0586,387,240 - 86,554,102 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Celera582,598,401 - 82,765,611 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238273   ⟹   XP_006238335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,125 (-)NCBI
Rnor_6.0586,387,238 - 86,554,108 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238274   ⟹   XP_006238336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,120 (-)NCBI
Rnor_6.0586,387,238 - 86,554,108 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238276   ⟹   XP_006238338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,118 (-)NCBI
Rnor_6.0586,387,238 - 86,554,108 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238277   ⟹   XP_006238339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,116 (-)NCBI
Rnor_6.0586,387,238 - 86,554,107 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238278   ⟹   XP_006238340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,117 (-)NCBI
Rnor_6.0586,387,238 - 86,554,107 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238279   ⟹   XP_006238341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,032 (-)NCBI
Rnor_6.0586,387,238 - 86,554,107 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238280   ⟹   XP_006238342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,120 (-)NCBI
Rnor_6.0586,387,238 - 86,554,108 (-)NCBI
Rnor_5.0590,474,206 - 90,641,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763760   ⟹   XP_008761982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,127 (-)NCBI
Rnor_6.0586,387,238 - 86,554,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593184   ⟹   XP_017448673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,129 (-)NCBI
Rnor_6.0586,387,238 - 86,554,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109346   ⟹   XP_038965274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,969,137 (-)NCBI
mRatBN7.2583,792,282 - 83,954,045 (-)NCBI
RefSeq Acc Id: XM_039109347   ⟹   XP_038965275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
mRatBN7.2583,792,282 - 83,961,117 (-)NCBI
RefSeq Acc Id: XM_063287220   ⟹   XP_063143290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
RefSeq Acc Id: XM_063287222   ⟹   XP_063143292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
RefSeq Acc Id: XM_063287223   ⟹   XP_063143293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
RefSeq Acc Id: XM_063287224   ⟹   XP_063143294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8588,807,402 - 88,976,005 (-)NCBI
RefSeq Acc Id: NP_775157   ⟸   NM_173134
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot),   F1M4B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238336   ⟸   XM_006238274
- Peptide Label: isoform X2
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238342   ⟸   XM_006238280
- Peptide Label: isoform X13
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238335   ⟸   XM_006238273
- Peptide Label: isoform X1
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238339   ⟸   XM_006238277
- Peptide Label: isoform X6
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238338   ⟸   XM_006238276
- Peptide Label: isoform X5
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238341   ⟸   XM_006238279
- Peptide Label: isoform X11
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238340   ⟸   XM_006238278
- Peptide Label: isoform X10
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761982   ⟸   XM_008763760
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K6K7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448673   ⟸   XM_017593184
- Peptide Label: isoform X4
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007710   ⟸   ENSRNOT00000007710
Ensembl Acc Id: ENSRNOP00000073851   ⟸   ENSRNOT00000083340
RefSeq Acc Id: XP_038965275   ⟸   XM_039109347
- Peptide Label: isoform X9
- UniProtKB: A0A3G1T2C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965274   ⟸   XM_039109346
- Peptide Label: isoform X7
- UniProtKB: Q9JLH5 (UniProtKB/Swiss-Prot),   K7QQW0 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000086335   ⟸   ENSRNOT00000095333
Ensembl Acc Id: ENSRNOP00000096134   ⟸   ENSRNOT00000118617
Ensembl Acc Id: ENSRNOP00000086004   ⟸   ENSRNOT00000095599
RefSeq Acc Id: XP_063143290   ⟸   XM_063287220
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063143294   ⟸   XM_063287224
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063143293   ⟸   XM_063287223
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063143292   ⟸   XM_063287222
- Peptide Label: isoform X12
Protein Domains
Centrosomin N-terminal motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLH5-F1-model_v2 AlphaFold Q9JLH5 1-1903 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693809
Promoter ID:EPDNEW_R4334
Type:multiple initiation site
Name:Cdk5rap2_1
Description:CDK5 regulatory subunit associated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0586,554,106 - 86,554,166EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708451 AgrOrtholog
BioCyc Gene G2FUF-41009 BioCyc
Ensembl Genes ENSRNOG00000005788 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007710 UniProtKB/TrEMBL
  ENSRNOT00000007710.7 UniProtKB/Swiss-Prot
  ENSRNOT00000083340.2 UniProtKB/TrEMBL
  ENSRNOT00000095333.1 UniProtKB/TrEMBL
  ENSRNOT00000095599.1 UniProtKB/TrEMBL
  ENSRNOT00000118617.1 UniProtKB/TrEMBL
InterPro CDK5RAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cnn_1N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286919 UniProtKB/TrEMBL
NCBI Gene 286919 ENTREZGENE
PANTHER CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot
  CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46930 UniProtKB/TrEMBL
Pfam Cnn_1N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk5rap2 PhenoGen
RatGTEx ENSRNOG00000005788 RatGTEx
UniProt A0A0G2K6K7 ENTREZGENE, UniProtKB/TrEMBL
  A0A3G1T2C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2Q6_RAT UniProtKB/TrEMBL
  A0A8I6A3L0_RAT UniProtKB/TrEMBL
  A0A8I6AL63_RAT UniProtKB/TrEMBL
  A6J805_RAT UniProtKB/TrEMBL
  A6J806_RAT UniProtKB/TrEMBL
  CK5P2_RAT UniProtKB/Swiss-Prot
  F1M4B7 ENTREZGENE, UniProtKB/TrEMBL
  K7QQW0 ENTREZGENE
  Q9JLH5 ENTREZGENE
UniProt Secondary K7QQW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Cdk5rap2  CDK5 regulatory subunit associated protein 2    CDK5 activator-binding protein  Name updated 1299863 APPROVED
2004-09-10 Cdk5rap2  CDK5 activator-binding protein  LOC286919    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with p35nck5a complexed with Cdk5 632478